Sentences with phrase «as gene regulation»

These studies are unable to determine a causal relationship due to factors such as gene regulation — a genetic variant may instead contribute to altered expression levels of true causal genes, which remain undetected by a GWAS.

Animals need these as essential nutrients for a wide range of basic bodily chores, such as gene regulation, cell signaling and amino acid breakdown.

Because RNA carries the genetic message from DNA to the cell's proteinmaking factories, or can directly perform acts such as gene regulation, it, too, is an appealing target for therapies.

This complex process of controlling the production of proteins is known as gene regulation.

Not exact matches

Interestingly, as many as nine of the genes have been previously associated with some vascular disease and four more are known to be involved in the regulation of vascular tone, supporting the importance of blood vessels in migraine attacks.

The focus thereby was on microRNA — a short, single - stranded RNA molecule that is now recognised as playing an important role in gene regulation.

«The reversible nature of the m6A methylmark adds a new layer to the regulation of gene expression now termed «epitranscriptomics» and warrants further research to establish links with human disease such as cancer,» adds Dr Irmgard Haussmann of Coventry University.

The auf1 gene had previously turned up as a player in cytokine regulation.

But with smaller parties standing to gain political influence, battles over issues such as the regulation of gene - edited organisms and how to cut greenhouse - gas emissions could grow fiercer.

The Greens want the same strict regulation for organisms that have been gene edited with precision technologies such as CRISPR, as has been put in place for those modified with conventional, less precise techniques.

The unexpected finding may also spark a new avenue of research on a type of gene regulation known as imprinting.

Histones and other proteins, when modified by this process known as acetylation, play critical roles in regulation of gene expression, typically resulting in increased gene expression.

«Changes in genes» regulation — not in the DNA sequence of genes themselves — were the driving force behind successful metastases in our experiments, and, as far as we know, this is the first genomewide experimental evidence for this phenomenon.»

Now researchers have identified a mutation in the human ATP4a gene that is involved in the gastric acid secretion regulation and has been identified as responsible of an aggressive form of inherited, early - onset gastric NET.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

Rather than inert spools, histones are increasingly seen as active cogs in a cell's gene regulation machinery.

The second insight involved changes in the evolution of gene regulation: As social complexity increased, so did the speed of changes to parts of the genome involved in regulating gene activity, located in the promoters of the genes, the researchers report.

This form of interference with bacterial gene regulation is also of pharmaceutical interest as it is known that pathogenic bacteria can protect themselves against attack by the immune system and the effect of antibiotics by forming biofilms, for instance on the epithelium of the respiratory system.

To achieve this, the researchers took advantage of a phenomenon known as quorum sensing, which is used by many species of bacteria to coordinate gene regulation in response to their population density.

It seems to be that we also get a fine - tuned as well as important gene regulation machinery that can be influenced by our environment and individual lifestyle.

A vital and ancient component of gene regulation, miRNA tunes the expression of as many as 30 - 60 % of mammalian protein - encoding genes, usually silencing them.

The open portions of the genome include genes themselves, as well as many regions that contribute to the regulation of their activities (the switches).

While the study represents a strong start for understanding how eQTLs affect gene regulation and expression, Engelhardt pointed out that she and her colleagues still do not have enough samples to understand trans - eQTLs as deeply as they would like.

Dillman explained that his research team also learned more about gene regulation and the evolution of genomes in general as it compared the five sequences with other nematodes.

New gene - editing technologies such as CRISPR have sped the development of new crop varieties and animals, but products based on engineered organisms sometimes face a web of complex and overlapping regulations before they can reach the market.

Moreover, the ability to easily program sequence - specific DNA targeting and cleavage by CRISPR - Cas components, as demonstrated for Cas9 and Cpf1, allows for the application of CRISPR - Cas components as highly effective tools for genetic engineering and gene regulation in a wide range of eukaryotes and prokaryotes.

The team discovered that the genes responsible for the regulation of NRL became more refined in the placental mammals as the modern retina evolved and were lost in several non-mammalian groups.

Examples include gene technology, where regulations in China are not as stringent as in the United States.

«We realized that studying the lithium response could be used as a «molecular can - opener» to unravel the molecular pathway of this complex disorder, that turns out not to be caused by a defect in a gene, but rather by the posttranslational regulation (phosphorylation) of the product of a gene — in this case, CRMP2, an intracellular protein that regulates neural networks,» added Snyder.

Scientists have discovered many points of regulation in the process of using a specific DNA template to make a protein, known as gene expression, that allow the cell to control how much of a certain protein is made at a certain time.

Many miRNA genes, therefore, lack annotated features such as a promoter or splice sites, hindering progress in understanding their transcriptional and post-transcriptional regulation.

We had suspected that the Mycoplasma genome might have a similar overall organisation to other bacteria, but we were completely surprised to find that it was also organised into domains, which can be considered as regulatory units of chromatin organisation and that we had identified a previously unknown layer of gene regulation.

This work is one basis for the use in the scientific community of transgenes as a major technique to study gene regulation in normal and malignant cells.

Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of gene duplications; alterations in regulatory, non-protein-coding elements in the genome; accelerated evolution of protein - coding elements, especially in genes for pigmentation; and other distinct features that affect gene expression, such as insertions of transposable elements and regulation by novel microRNAs.

Transcriptional regulation information for a gene, including any predicted DNA binding site motifs (YeTFaSCo) for the gene's protein product, as well as any of its targets (genes it regulates) or regulators (genes that regulate it), based on experimental evidence.

The involvement of NF - κB in β - interferon gene regulation reveals its role as widely inducible mediator of signal transduction.

Fold change of genes identified for regulation of skeletal extension and growth, is presented as treated vs. control during daytime, night - time and without treatment.

Transgenic mice are extremely useful for scientists studying gene function or regulation and human diseases, such as Alzheimer's disease.

What is known from global studies is that exposure to biologically active compounds, even at ng / L concentrations, can impact endocrine systems in nature and manifest as negative impacts like altered gene regulation, the presence of mixed reproductive tissues (intersex) and skewed sex ratios.

This could be an indication of a controlled expression of genes responsible for calcification during daytime, as evidenced by the up - regulation of genes associated with the cartilage and bone biogenesis process.

Transcriptome studies such as the National Institute of Health's Genotype - Tissue Expression (GTEx) program aim to overcome this limitation by studying gene expression levels and regulation mechanisms and their relationship with diseases, instead of only DNA sequence.

RNA - based gene regulation is revealing itself as key to understanding cellular function, organismal development and homeostasis.

In this study, we also identify p21waf1 / cip1 as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression is linked to the growth - suppressive effect exerted by DDX3 (see Fig. 2).

Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.

Several functions vary among the members of this group of bacteria, such as metabolism of nitrogen, respiration, cell wall and capsule, stress response, secondary metabolite biosynthesis, regulation and cell signaling; this variation in gene functions could help us understand the ability of colonization and adaptability of these rhizosphere - colonizing bacteria.

Additionally, we identified p21waf1 / cip1, a cyclin - dependent kinase inhibitor, as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression accounted for the colony - suppressing activity of DDX3.

Bach1 is a member of the BTB and CNC transcriptional regulator family that, like Nrf2, binds to ARE sequences as heterodimeric complexes with small Maf proteins [18] A major physiological role for Bach1 is in iron homeostasis through regulation of the expression of heme oxygenase - 1 (HMOX1), ferroportin (FPN1) and Ferritin (FTH) genes [23], [24], [33], [41].

Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...

We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.

For each such peak, they identified genes within 50 kb as potential targets of regulation.