Sentences with phrase «as gene targeting»

Their research has created the technology known as gene targeting, now used in virtually all areas of biomedicine — from basic research to the development of new therapies.

Competitive pathway analysis implicated the biological processes of neurogenesis and synaptic regulation, as well as the gene targets of two pharmacologic agents: cinnarizine, a T - type calcium channel blocker, and LY97241, a potassium channel inhibitor.

Not exact matches

Luxturna is the first of a crop of treatments that target diseases caused by mutations in specific genes, and thus is referred to by many as the first gene therapy in the U.S.

The Kamens claim the main thing that distinguishes their foundation from other brain tumor foundations is their focus on pediatric brain cancer specifically, as well as their close ties with pharmaceutical and biotech companies working in the fields of immunotherapy and target gene therapy.

During the dialogue, Dr Gene Nisperos of the Health Alliance for Democracy raised his concern as the target of Golden Rice are members of the vulnerable population such as preschool children and lactating mothers.

Using a gene - sequencing technique known as whole - exome sequencing that targets only the DNA that encodes proteins, the researchers cataloged virtually every significant DNA variant in three families in which the condition is common.

«The extensive overlap in risk genes for autism and cancer, many of which are chromatin remodeling factors, supports the idea of repurposing epigenetic drugs used in cancer treatment as targeted treatments for autism,» said Yan.

As the target gene's methylation changes, so does the reporter's.

The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manner.

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient's response to therapy.

They note that targeting inflammation to treat infections offers an advantage over antibiotic therapy, as the former hinders gene transfer and the evolution of pathogens, while the latter promotes bacterial evolution and, ultimately, antibiotic resistance.

If so, the master genes would be even more promising as targets for new treatments.

Earlier MD Anderson investigations demonstrated exosomes as a factor in detecting pancreatic cancer, but these latest findings reveal genetically altered exosomes as a potentially novel approach for direct and specific targeting of mutated KRAS, the cancer gene commonly linked to pancreatic cancer.

The team had expected to find changes in many genes involved in serotonin signaling, a process targeted by some popular antidepressants such as Prozac.

Mutations to these genes can affect the choice of therapy as well as how to better target the mutations.

The target fragment binds to a gene switch in the DNA, which triggers the production of a colourful substance such as the protein that gives jellyfish a green glow under ultraviolet light, or proteins from bacteria that produce colour changes visible to the naked eye.

The researchers are now investigating the effects of these genes» mutations as possible targets for new therapeutic treatments.

Starting with a candidate list of 20,000 genes, researchers screened down to eight before singling out VNN - 1 as the primary target.

It turns out that each virus that's been studied and associated with cancer — such as hepatitis B with liver cancer or human papilloma virus with cervical cancer — evolves characteristics that allow it to target those genes immediately upon infection.

The gene expression similarities between this common condition and the current findings in late - stage RP suggest that the canine RP models could serve as stand - ins to evaluate the effectiveness of pharmaceutical interventions that target innate immunity pathways in AMD

The same process has been studied as a potential genetic therapy for more than a decade, because you can target any disease gene with matching dsRNA.

«Such changes may affect other genes as well; we haven't studied all the potential targets yet.

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.

NIPD for single gene disorders in a fetus is diagnostic, as it targets specific genetic changes present in a high risk family.

The analysis suggests that patients with complex indels in KIT would benefit from drugs such as imatinib, sunitnib and sorafenib, which target mutations in this gene.

Despite this high profile, K - Ras has earned a reputation in scientific circles as being «undruggable» because many pharmaceutical, biotech, and academic laboratories have failed to design a drug that successfully targets the mutant gene.

Importantly, this monoubiquitination serves as an integral part of SETDB1 to render its activity and leads to inhibition of target gene expression.

But hopes that ageing could be delayed by targeting a single gene or protein in a single molecular pathway have faded, as researchers have learned that the key pathways vary according to the animal.

«Gene defect as a potential gateway for targeted prostate cancer therapy.»

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

Further investigation uncovered CHD1's role as vital to PTEN signaling, and as a potential therapeutic target in prostate and breast cancers with PTEN gene loss.

«A retrospective analysis of the CHD1 gene in these samples may reveal the potential utility of CHD1 as a biomarker for improved prostate cancer patient stratification and targeted therapy with PARP inhibitors,» notes Johnsen.

The authors also provide experimental validation for using active genetics as an efficient means for targeted gene insertion, or «transgenesis,» and single - step replacement of genetic control elements.

Significant binding by miR -124-3p to two of the potential target genes was seen, as measured from immunoprecipitated RNA - induced silencing complexes.

As the central nervous system is also a target of AAV vectors, Hélène Puccio and Patrick Aubourg's teams are investigating whether a similar approach using gene therapy could be as effective for the spinal cord and cerebellum as it is for the hearAs the central nervous system is also a target of AAV vectors, Hélène Puccio and Patrick Aubourg's teams are investigating whether a similar approach using gene therapy could be as effective for the spinal cord and cerebellum as it is for the hearas effective for the spinal cord and cerebellum as it is for the hearas it is for the heart.

They combined the protein with synthetic molecules, known as PNAs, that mimic DNA and bind to the target gene to form a triple helix.

CRISPRs are bacterial immune systems that contain many defense enzymes such as the Cas9 «molecular scissors,» which scientists including Hsu have engineered as a powerful DNA - targeting gene - editing tool.

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

But only after engaging the target and adjusting their antigen receptors over many generations (as B cells do by mutating their antigen receptor genes) can this lineage of cells produce VRC26 bnAbs.

Experimental approaches such as gene therapy are also being investigated, but Dr. Rudnicki's research suggests that these approaches will have to be modified so that they target muscle stem cells as well as muscle fibres.

«Since this gene has previously been identified as a target for the development of new drugs, in the future, it may be possible that early detection will facilitate better management of this disease.»

By mapping the neural processes involved as birds learn mating songs, scientists hope to someday use that knowledge to target specific genes disrupting speech in patients with autism or other neurodevelopmental conditions.

Many cancer drugs target one of the soldier proteins that have already been expressed from a gene, have received marching orders from other proteins, and are well on their way to causing problems, such as metastasis.

Professor Moffatt said: «The genes we identified represent new potential drug targets for allergic diseases as well as biomarkers that may predict which patients will respond to existing expensive therapies.»

Intrigued by the ability of certain polymers to mop up DNA and RNA for gene transfer, Sullenger and colleagues tested the idea that these chemical compounds might also be effective targeting such nucleic acids as they arise in cell death.

In animals such as mice, it is fairly routine to study gene functions by deleting a target gene or replacing it with an artificial piece of DNA.

Led by Massey's Deputy Director Steven Grossman, M.D., Ph.D., a team of scientists targeted the gene CtBP with a drug known as HIPP (2 - hydroxy - imino phenylpyruvic acid) and were able to reduce the development of pre-cancerous polyps by half and return a normal lifespan to mice born with a predisposition to intestinal polyps.

The non-pathogenic vectors serve as gene shuttles to transport components of SIV, such as envelope proteins, into the target cells.

The first group was mice with targeted deletion of the interleukin 10 (IL10) gene, known as interleukin 10 knockout (IL10 - / --RRB- mice, which develop colitis through T helper immune cells.