Sentences with phrase «as gene transcription»

Apart from that, the team has managed to show that the ANKRD55 proteins reside in the nuclei of the cells, and that suggests that they could play a significant role in the specific processes that take place in the cell nucleus such as gene transcription.

He will promote high - throughput technologies in areas that are «poised for this kind of approach,» such as gene transcription and autism studies.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

Not exact matches

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manner.

The gene encodes a transcription factor, a protein that in this case binds to DNA and allows it to be read out as messenger RNA.

As in any good marriage, moreover, the attachment of the methyl groups significantly altered the behavior of whichever gene they wed, inhibiting its transcription, much like a jealous spouse.

Ultimately, this week's discourse will lead to a consensus statement providing some guidance on how to approach using this and older gene editing technologies such as zinc finger nucleases and enzymes called transcription activator - like effector nucleases, or TALENs.

When a gene is switched on, one of its strands is copied into the related chemical RNA, a process known as transcription.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

In most cases, the genes responsible for these processes are known as «transcription factors» — meaning that they are responsible for turning other genes on and off.

We know that Hox genes encode transcription factors that control the activity of other genes, but we found that digit - innervating motor neurons also express other genes, such as FIGN and CNEP4], and we still don't know the function of any of these other genes.

Unlike most proteins, those with these special domains can actually bind to DNA and act as transcription factors — telling specific genes to turn on or off.

The virus doesn't kill the cell, but it suppresses transcription and translation of genes, so the organism as a whole suffers but the individual cell looks OK.

This work, published in the journal Molecular Cell, reveals a new role for each nucleus» several hundred pores, which constitute as many microscopic factories of gene transcription.

Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus - like eremophytes instead of normal plants from the drought).

Using the recently completed tomato genome sequence they then identified the gene as SlGLK2 — a so - called transcription factor, which controls when and where other genes are switched on or off.

The researchers show that, when ethylene is perceived, transcription of certain genes that function as circuit breakers of ethylene signaling occurs, but protein production becomes restricted until ethylene is removed.

She and her colleagues propose that other replication inhibitors to fight cancer will also produce unique double strand break profiles, as gene expression patterns would dictate the locations of replication - transcription conflicts.

The researchers also investigated the impact of aneuploidy on other biological pathways, such as transcription, the first stage of gene expression in which a segment of DNA is copied into RNA.

Only some of the plant's 30,000 genes are active in a given root cell at a given time, thanks to proteins called transcription factors that turn genes on and off as needed.

Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway.

Naturally, every gene is not regulated by its own distinct transcription factor; otherwise, a codebook of as many as 30,000 genes would require 30,000 transcription factors — and 30,000 more genes to code for them.

This type of histone methylation enables the function of these regions as enhancer sequences, i.e. as marks that can be identified by specific proteins which boost gene transcription.

They later showed that RORA, a nuclear hormone receptor that functions as a transcription factor, can potentially regulate the transcription of more than 2,500 genes, including over 400 genes already associated with autism.

The genes for each transcription factor were made from different bits of DNA that code for the functional parts of proteins, such as a domain that can bind to DNA and another that provides the protein with access to the cell's nucleus.

MYCN and its kin are «transcription factors,» proteins that bind to DNA and influence the rate at which genetic information is used by the cell — essentially serving as brightener / dimmer switches for gene activity.

The new consortium proposes to characterize and tag the 1486 known transcription factors — proteins that switch genes on and off — in the mouse genome, as well as an estimated 600 coregulators that chip in to control cellular and biological functions through networks called regulons.

On the other hand, as a dimer, it directly binds to response elements in the DNA (GC - response elements), thus inducing gene transcription (transactivation).

The master regulator transcription factors and super-enhancers work together to regulate the expression of critical genes, such as those responsible for cell identity.

In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.

The researchers classified pri - miRNAs into three broad categories based on gene structure: Class I, which are transcribed independently of other genes and likely represent independent transcription units, Class II, which are transcribed as an extension of a protein - coding gene, and Class III, which are transcribed as an extension of a noncoding RNA.

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

It turns out, as depicted by the model, that Ascl1 acts as a pioneer transcription factor that is capable of opening closed chromatin, and recruit the other factors to induce neuronal gene transcription.

We aim to comprehensively annotate functional elements, decipher genomic codes of transcription, as well as coding and non-coding gene function during development and enhance zebrafish as an attractive developmental, comparative and disease model.

This finding is consistent with the recent discovery with several «eukaryotic» signature genes in these archaeal lineages, including genes encoding proteins such as actin, tubulin, and several proteins involved in transcription and membrane deformation.

In fact, they found that TGF - β halts both the transcription of the p53 gene - the process by which cellular machinery reads the DNA code for a gene - and the subsequent process by which the corresponding p53 protein is produced, known as translation.

Study coauthors Rammohan Rao of the Buck Institute for Research on Aging and Dale Bredesen of the Buck Institute and UCLA «have provided evidence for a novel — in fact, radical — idea: that ApoE somehow gains access to the nucleosol and acts as a conventional transcription factor, influencing the expression of a large number of genes,» Steven Barger, who studies neurodegenerative disease at the University of Arkansas for Medical Sciences and was not involved in the study, wrote in an email to The Scientist.

The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

The histone proteins are decorated with different marks, which can affect the various activities of the modified DNA such as transcription, gene silencing, imprinting and replication.

Multiple transcripts arising from alternative initiation or polyadenylation sites, or alternative RNA splicing at a single locus were not considered as multiple genes but as variants of a single transcription unit.

Since the two most reliable estimates based on cloned material vary from 11,000 to about 13,000 transcription units, we take 12,000 as a working figure for the number of protein coding genes in D. melanogaster.

However, the authors found no evidence for a role of Setd7 in histone methylation or as a partner of MyoD in MuSCs and instead, they discovered that Setd7 interacted with - catenin and modulated its methylation status to promote nuclear translocation and the transcription of Wnt - responsive myogenic genes.

The MYC protein acts as a transcription factor that governs the expression of many important genes.

As a researcher of the molecular mechanisms of gene transcription, Sampley Bohn conducted her postdoctoral research at the National Institutes of Health in the National Institute of Child Health and Human Development.

That being said, we generally pick guides by putting the promoter of the gene into a gRNA finder such as WU - CRISPR (6) or our lab's sgRNA scorer 1.0 (7) and picking whichever guides are closest to the transcription start site (TSS).

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

Smyd3 is identified as a novel «histone - code reader» protein, which invades active chromatin domains and potentiates the transcription of cancer - related genes.

Genes under LITE control showed a rise in transcription in as little as 30 minutes after light stimulation.

Melanocytes respond by altering gene transcription, and these changes in gene expression profiles result in easily quantifiable phenotypes such as modified pigment production (a hallmark of melanocyte differentiation state) and changes in morphological cell properties.