Sentences with phrase «as genetic markers»

Genetic studies have linked multiple forms of cancer with specific breeds and more will likely be discovered as genetic markers are identified.

Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline - induced cardiotoxicity in children.

Botstein and Davis led an effort that resulted in an idea that at the time was absolutely radical, namely, that you don't have to map the observable traits, known as phenotypes, but instead can follow inheritance patterns using random differences in DNA as genetic markers — differences neutral to evolution and that have nothing to do with observable traits.

Following this insight, the first genetic maps that allowed researchers to trace patterns of inheritance in humans were made using as genetic markers locations on chromosomes where restriction enzymes slice through the DNA.

Single nucleotide polymorphisms (SNPs, used as genetic markers in DNA profiling) can produce single amino acid polymorphisms (SAPs) in the amino acids that make up protein.

«Recent scientific advances have enabled us to identify a trove of neurotransmitters and detect relevant neural brain pathways as well as genetic markers that help explain the biology of the placebo effect,» said Kaptchuk.

«To test the importance of such structural alteration as a genetic marker, a phase two clinical trial is ongoing at Kagoshima University and other institutions,» adds Ogawa.

The authors will follow up the study with additional worldwide populations to better understand the mutations and these genes as a genetic marker for disease risk.

Not exact matches

Think of people declining to get tested for the genetic markers of a hereditary disease, or a smoker whose cigarette packs might as well have that warning from the Surgeon General printed in invisible ink.

We employ conventional breeding and new tools in genetics and genomics — such as marker - assisted selection — as well as genetic modification.

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

Researchers from several institutions, including, UCLA, Boston University, Stanford University and the Institute for Aging Research at Hebrew SeniorLife, analyzed blood samples from nearly 10,000 people to find that genetic markers in the gene responsible for keeping telomeres (tips of chromosomes) youthfully longer, did not translate into a younger biologic age as measured by changes in proteins coating the DNA.

For some strains of bird flu virus, notably the worrisome H5N1 variant, the genetic changes that could make human - to - human transmission a possibility and spark a pandemic are the markers of intense interest to those who track flu as a threat to human health.

Fully sequenced genomes remain rare, so the bulk of the analysis was done by looking at genetic markers known as single nucleotide polymorphisms or SNPs.

The study involved participants of European descent exclusively, but co-author Roy Perlis, a researcher at Massachusetts General Hospital, notes it's standard method to focus on one group as a starting point, since previous research shows genetic markers can vary by ethnicity.

The lab has also shifted from testing genetic markers known as short tandem repeats (STRs), which are standard in paternity testing, to recording single letter variants in the genetic code known as single nucleotide polymorphisms, or SNPs, which are rarely used for this purpose.

«Our findings show that a specific genetic marker (known as allele * 2 of the HS1, 2 A enhancer region) influences not just disease activity in RA patients, but also response to therapy in the early stages of their disease,» said lead investigator Dr Gabriele Di Sante of the Institute of Rheumatology and Related Sciences, Catholic University of the Sacred Heart, Rome, Italy.

Often such trials include genetic markers for drugs that target particular pathways, such as a kinase inhibitor for cancer treatment.

Eggleston's part of the project was aimed at finding genetic markers that would help biologists zero in on the genes that cause defects in purebred dogs, such as hip dysplasia and epilepsy.

There are now three genetic - risk categories, rather than four, and the FLT3 - ITD mutation has been added as a marker of risk;

Studies of genetic markers that are distinctive to ancestral groups show that typical African Americans have 20 percent European blood, although that figure can go as high as 80 percent in some people who call themselves black.

A selection of Joe Davis's colorful «prayer flags,» which are printed with the code for the genetic markers of diseases such as cancer, Parkinson's and Huntington's.

Over the last 20 years, genetic research has provided many markers of susceptibility, just as Perera and Weinstein predicted.

This work resulted in thousands of genetic markers for snake specimens collected as far back as the early 1900s.

Most simply, once these genes, or bits of DNA tied to the genes (known as markers), have been identified, molecular breeders can quickly target offspring inheriting the genes for further development, cutting breeding time and improving the crop's «genetic gain,» the generational improvements made to a crop, like increased height, by human selection.

With the advent of more and more sophisticated ways to measure genetic variation and relatedness using molecular markers, such as allozyme polymorphisms and DNA - based markers, not only can individuals be tracked as to their parentage, but changes in allele patterns over time and thus the effects of evolution on populations can be «seen» in the genetic information.

This is why our system is innovative and powerful, as we don't have to spend the time to identify and develop a new genetic or protein marker for every kind of cancer.»

A series of genetic markers sprinkled throughout the cells» chromosomes show the same pattern found in parthenogenetic mice as opposed to cloned mice, according to a report published online today in the journal Cell Stem Cell.

Lately, as envirogenomics has taken off, scientists have begun to test for genetic markers in humans who are most heavily exposed to pollutants, an effort that got a huge boost in 2006 when Congress approved the $ 40 million Genes, Environment, and Health Initiative, a program administered by the National Institutes of Health (NIH).

These so - called genome - wide association studies have turned up hundreds of genetic markers linked to diseases such as cancer and diabetes.

As with other genetic studies linking diseases to DNA markers, her research tends to compare populations who have one variation of a genetic marker with those who have a different variation — a comparison that has limited application to individuals.

«Health information, in particular, which can encompass a variety of things from sleep patterns to diagnoses to genetic markers, the data gathered about us can paint a very detailed and personal picture that is essentially impossible to de-identify, making it valuable for a variety of entities such as data brokers, marketers, law enforcement agencies, and criminals,» says Michelle De Mooy, director of the Privacy & Data Project at the Center for Democracy & Technology.

Hence, understanding the interrelationship between genetic markers and use of aspirin and NSAIDs, also known as gene × environment interactions, can help to identify population subgroups defined by genetic background that may preferentially benefit from chemopreventive use of these agents and offer novel insights into underlying mechanisms of carcinogenesis.

The booklet discusses in detail and in simple language agricultural biotechnology as it compares with conventional breeding, the agricultural biotechnology tools used in crops such as tissue culture and micropropagation, molecular breeding and marker - assisted selection, and genetic engineering and GM crops.

The ubiquity of these markers and the fact that these polymorphisms show variation at such a fine scale (i.e., at the individual level) makes them ideal markers for many applications, such as population - level genetic diversity studies and genetic mapping in plants.

In collaboration with data - sharing networks, namely MalariaGEN and STOP - HCV, they are using genetics as a tool to investigate the underlying biology of infectious diseases and to identify genetic markers that correlate with clinical outcomes.

The new method allows for the detection of polymorphisms between individuals, which will be useful for downstream applications such as marker - assisted selection, linkage and QTL mapping, and genetic diversity studies.

This effort, which will enhance deCODE's proprietary gene and drug target discovery work and may provide genetic markers for additional diagnostic development, will leverage Illumina's Sentrix ® HumanHap BeadChips; Infinium ™ assay and LIMS (laboratory information management system); as well as analysis and visualization tools from Illumina's BeadStudio software.

Similar to other Unyvero Applications, Unyvero UTI allows the rapid detection of pathogens and genetic resistance markers in a broad range of routinely available patient sample types, such as midstream urine, catheter urine, suprapubic aspiration, and tissue.

Dr Linus Girdland - Flink, who is based at LJMU's School of Natural Sciences and Psychology, and senior author of the study, comments: «Previous studies on the Guanches have relied on single genetic markers, such as mitochondrial DNA and Y - chromosomes.

During sabbatical in the laboratory of Chris Tyler - Smith (Wellcome Trust Sanger Center), I genotyped the Y chromosome of HapMap samples with 16 short tandem repeat (STR) markers as well as lineage specific markers to determine whether the Y chromosome genetic information in this sample was consonant with the purported ancestry of the subjects.

Gene expression Reporter genes, such as luciferase or GFP, can also be assessed in microplate readers, enabling in vitro and in vivo determination of gene expression for studies using markers of genetic alteration.

Cancer cells discharge these mutated proteins — which become markers for the immune system — as a result of genetic mutations, said study co-author Jonathan Serody, MD, UNC Lineberger's associate director for translational research.

Research in Psychological Science noted that women who are ovulating act more flirtatious with men who have more markers of «genetic fitness,» such as attractiveness and masculinity.

While I completely agree with delaying grains as long as possible because the digestion is immature early on, research actually shows that people who carry the genetic markers for celiac (not all carriers will actually develop celiac - there appear to be environmental conditions that contribute to its development) are least likely to develop the disease if gluten is introduced around 6 months of age in small quantities.

«Just because you have genetic markers for things doesn't mean you necessarily have associated risks as long as you are eating real foods.»

Testing for lipoprotein genetic markers, such as the apoE genotype, can help evaluate a patient's inherited cardiometabolic risk.

Coagulation genetic markers, such as Factor V Leiden and Prothrombin G20210A Mutation, determine whether a patient is at significantly higher risk for blood clotting.

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It is also the most accurate Dog DNA test kit, as it tests for 50X more genetic markers than competitors.