Sentences with phrase «as hematopoietic»

A new role for the human placenta as a hematopoietic site throughout gestation.

It is known as a hematopoietic growth factor or colony stimulating factorand is given by injection under the skin (subcutaneous) or in the vein (intravenous).

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

Other adult stems cells exist — such as hematopoietic stem cells, which can generate all types of blood cell and mesenchymal stem cells, which can turn into bone, fat and cartilage cells.

Not exact matches

I spent the next decade completing rigorous basic science research training: completing a high school summer internship, attending the University of Maryland, Baltimore County as a Meyerhoff Scholar, and completing my Ph.D. in the Stanford immunology program, where my work focused on the mechanisms regulating hematopoietic and leukemic stem cells.

UTSW co-authors include: Co-lead author Maria Winter, a research associate; Dr. Luisella Spiga, a postdoctoral researcher; visiting fellow Lisa Büttner; graduate students Elizabeth Hughes and Caroline Gillis, all of Microbiology; Dr. Breck Duerkop, Instructor, Immunology; Cassie Behrendt, a research technician, Immunology; Dr. Lora Hooper, Professor and Chair of Immunology with appointments in Microbiology and in the Center for the Genetics of Host Defense, a HHMI Investigator and holder of the Jonathan W. Uhr, M.D. Distinguished Chair in Immunology, and the Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell; Dr. Luis Sifuentes - Dominguez, Instructor of Pediatrics; Dr. Kayci Huff - Hardy, clinical fellow, Internal Medicine in the Division of Digestive and Liver Diseases; Dr. Andrew Koh, Associate Professor of Pediatrics and Microbiology and in the Harold C. Simmons Comprehensive Cancer Center as well as Director of Pediatric Hematopoietic Stem Cell Transplantation at Children's Health; and Dr. Ezra Burstein, Professor of Internal Medicine and Molecular Biology and Chief of the Division of Digestive and Liver Diseases.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

Autologous hematopoietic stem cell transplantation (AHSCT) has been investigated as a treatment for aggressive MS, the rationale for which is immune reconstitution.

The blood ancestors are usually called hematopoietic stem cells; these cells were classically defined as a specific category of multipotent cells at the top of the hierarchy that can differentiate into any blood cell type by following a deterministic program.

«Active HSCs (hematopoietic stem cells) form the daily supply line that continually replenishes worn - out blood and immune cells while the reserve pool serves as a backup system that replaces damaged active HSCs and steps in during times of increased need,» explains Li.

Hematopoietic stem cell transplantation (HSCT), once considered an effective yet risky alternative to drug therapy for blood cancer, has become more accessible and successful in a wide range of patients as a result of major advances in transplant strategies and technologies.

Aging is a key risk factor for sAML because, over time, hematopoietic stem cells (which give rise to all other blood cell types) accumulate DNA mutations and changes in other molecules that put DNA instructions into action, such as RNA and proteins.

The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.

The discovery could provide insight for using megakaryocyte - derived factors, such as TGF - B1 and FGF1, clinically to facilitate regeneration of hematopoietic stem cells, he adds.

Since her recruitment at SR - Tiget as an independent Project Leader in 2012, promoted to Group Leader in 2016, her team investigates the molecular mechanisms of host - vector interplay during gene transfer in human hematopoietic stem cells (HSC).

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.

As a result, they are currently being investigated as a cellular therapeutic for the treatment of autoimmune diseases and long - term patient and graft survival following solid organ transplantation, and allogeneic hematopoietic stem cell transplantatioAs a result, they are currently being investigated as a cellular therapeutic for the treatment of autoimmune diseases and long - term patient and graft survival following solid organ transplantation, and allogeneic hematopoietic stem cell transplantatioas a cellular therapeutic for the treatment of autoimmune diseases and long - term patient and graft survival following solid organ transplantation, and allogeneic hematopoietic stem cell transplantation.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

Plerixafor has been approved by the FDA as the first small - molecule CXCR4 antagonist for use in combination with granulocyte - colony stimulating factor (GCSF) to mobilize hematopoietic stem cells to the bloodstream for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.

A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.

MSC do not express hematopoietic markers, but a specific pattern of molecules, such as SH2 (CD105), SH3, SH4 (CD73) and STRO - 1.

Emergence of small - molecule CXCR4 antagonists as novel immune and hematopoietic system regulatory agents.

Furthermore, these potentials are expanded by the notion that MSCs can exert functions other than those classically attributed to stem or progenitor cells, including establishment and support of the hematopoietic microenvironment in vivo, as observed for bone marrow derived MSCs.

But for blood cancer patients who receive donor hematopoietic stem cell transplants as part of their treatment, graft - versus - host disease (GVHD) often hampers their recovery.

Along the way, we became interested in using cord blood as an alternative donor source for hematopoietic reconstitution after myeloablative therapy.

Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all hematopoietic cell lineages.

The unique challenges of utilizing different cell types such as bi-specific CAR - T cells, regulatory T cells and hematopoietic stem cells.

Basically what was happening when you use a hematopoietic stem cell to correct an inherited metabolic disease is that through engraftment of that cell you are allowing that cell to become the replacement source for the missing enzyme or other factor - almost like a cellular form of gene therapy or, as I call it, «poor man's gene therapy».

Modulating ECM assembly to alter tumor vascular barrier function Weilan Ye, Genentech Lymphangiogenesis and lymphatic endothelial barrier as targets in regenerative medicine Giorgia Jurisic, Novartis Wnt / beta - catenin signaling as a therapeutic target for blood - brain barrier repair in neurological disorders Dritan Agalliu, Columbia University Somatic mutations in hematopoietic cells contribute to cardiovascular disease: New mechanisms, new targets Kenneth Walsh, Boston University

Before coming to Columbia she worked as a technician in Leonard Zon's lab at Harvard Medical School using zebrafish as a model for investigating the molecular mechanisms of hematopoietic stem cell differentiation and self renewal.

In response, St. Jude researchers have re-engineered a lentivirus to function as a vector to ferry a normal copy of IL2RG into the patients» hematopoietic stem cells.

As an extension to genetics projects, we now aim to identify and characterize in greater depth genes implicated in hematopoietic development in the EU FP7 - funded BLUEPRINT project, which will generate reference genomes and epigenomes of at least 100 specific blood cell types.

This is why transplants of HSCs (from bone marrow) are also used to treat cancers of the hematopoietic (blood) system, such as leukemia or lymphoma.

Allogeneic cell therapies involving primary cell types such as bone marrow mesenchymal stromal / stem cells (BM - MSCs), hematopoietic stem and progenitor cells (HSPCs), and T and natural killer (NK) cells for immunotherapy applications are especially challenging because of the vigorous process of screening...

Lentiviral - based gene therapy methods to modify human CD34 + hematopoietic stem cells have been investigated as a way of treating various hematological disorders including X-linked chronic granulomatous disease (X-CGD).

Title: Genetic Screen Identifies MicroRNA Cluster 99b / let -7 e / 125a as a Regulator of Primitive Hematopoietic Cells Authors: Gerrits A, Walasek MA, Olthof S, Weersing E, Ritsema M, Zwart E, van Os R, Bystrykh LV, de Haan G Date: 2012 Publication Details: Blood 2012 Jan 12; 119 (2): 377 - 387

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Additional in vitro and in vivo studies are needed to determine the cause of the specificity of JAK2V617F for myeloid diseases, as second mutations, host modifiers, differential cytokine receptor expression, and other factors may influence the ultimate phenotype of hematopoietic progenitors that acquire the JAK2V617F mutation.

A number of treatments exist, including enzyme replacement therapy and hematopoietic stem cell transplantation, but efficacy depends upon diagnosing the disease and its specific form as early as possible.

RIG - G gene expression can be induced not only by ATRA along with the differentiation of NB4 cells but also by IFNα in a series of hematopoietic cell lines as well as various types of solid carcinoma cells (1, 3), which pointed to a possible role of RIG - G in signal cross-talk between ATRA and IFNα.

Alternatively, embryonic stem (ES) cells have emerged as a potential source of less immunogenic hematopoietic progenitor cells (HPCs).

Allogeneic cells, particularly mismatched or haploidentical cells, in the context of hematopoietic transplantation have been found to provide potent immune surveillance for both hematologic and solid tumor malignancies in a process referred to as graft - versus - tumor [13]--[15].

IL - 6 has been shown to be involved in diverse physiological processes such as T - cell activation, induction of immunoglobulin secretion, initiation of hepatic acute phase protein synthesis, and stimulation of hematopoietic precursor cell proliferation and differentiation.

We further describe a mesenchymal sub-population with stem cell - like characteristics that gives rise to both lineages and, at the same time, acts as a principal component of the hematopoietic niche by promoting competitive repopulation following lethal irradiation.

These allogeneic cells have the potential to participate in immune surveillance for breast or other cancers as observed in clinical hematopoietic stem cell transplantation.

In this medium, the HOXB4 gene is activated and stoichiometrically expressed at a 1 ∶ 1 ratio with GFP, so that the cells turn green as they become hematopoietic.

Sf3b1 ^{K700E / +} animals had impaired erythropoiesis and progressive anemia without ringed sideroblasts, as well as reduced hematopoietic stem cell numbers and host - repopulating fitness.

RhoH is a newly identified hematopoietic small G protein, originally cloned as one of the genes frequently disrupted in diffuse large B cell lymphoma (1, 2).

Our study may implicate haploinsufficiency of protein - coding genes as a general mechanism of aging of the hematopoietic system and of aging - associated disorders more generally and provide new insights into the genetics of aging and healthspan.

The workshop will focus on topics such as; hematopoietic stem cell biology, leukemogenesis, cell signaling, transcription factors, epigenetic effects, and other topics related to myeloid biology.