Sentences with phrase «as hepatocyte»

Coffee enema was given four times a day, for the first year as hepatocyte destruction was recognized.

We start feeling the diffuse symptoms of an overburdened liver such as fatigue, depression, headaches, lack of clarity and skin rashes as the hepatocyte cells of our liver are destroyed.

Not exact matches

They found that hepatitis in these «human hepatocyte chimeric mice» was caused by white blood cells known as cytotoxic T lymphocytes (CTLs) that were specifically targeted to hepatitis B virus.

The hepatocytes are first patterned onto surfaces dotted with tiny spots of collagen, and then surrounded by supportive tissue made up of stromal cells, which act as connective tissue and support the hepatocytes in carrying out their liver functions.

However, unlike the primary hepatocytes, the hepatocyte - like cells offer an unlimited supply of test cells, since the researchers can simply grow more as required, Bhatia says.

This involved culturing two liver cells (hepatocytes) that can act as a functional organ unit on artificial membranes fabricated with microwell patterns.

«As mature hepatocytes die off, these clones replace the liver mass.

«We have shown that an endogenous peptide, catestatin, can directly suppress glucose production from hepatocytes and can indirectly suppress lipid accumulation in liver as well as macrophage - mediated inflammation in obese mice,» said Sushil K. Mahata, PhD, professor of medicine at UC San Diego School of Medicine.

Hepatocyte growth factor (HGF)(or scatter factor (SF) pathways - Met inhibitors could be used in combination with other treatment modalities such as; radiotherapy and / or immunotherapy in treatment of cutaneous melanoma.

Like human primary hepatocytes, Cellartis enhanced hiPS - HEP cells show important characteristics of mature hepatocytes such as expression of HNF4α, ASGPR1, and α1AT; albumin and urea secretion; and principal features of functional glucose and lipid regulation.

However, hiPS cell - derived hepatocytes are only useful as an in vitro model system and for gene editing applications if they recapitulate critical hepatocyte functions.

We combine experimental and computational approaches to investigate the molecular mechanisms underlying hepatocyte polarity as well as the 3D organization of the bile canaliculi and sinusoidal networks in the mouse and human liver tissue.

«Human hepatocytes are almost impossible to work with as they don't grow and are hard to maintain in culture,» explains senior author Inder Verma, Ph.D., a professor in the Laboratory of Genetics and holder of the Irwin and Joan Jacobs Chair in Exemplary Life Science.

«It is basically impossible to grow human hepatocytes in the lab, which was a big hurdle for the study of viruses such as hepatitis A and hepatitis B,» says senior author Inder Verma, Ph.D., a professor in the Laboratory of Genetics.

A second intriguing possibility would be the use of hiPSCs to produce functional cells for use in extra-corporeal applications, such as mature hepatocytes for use in bio-artificial livers.

Flow cytometric analysis of asialoglycoprotein receptor (ASGPR) levels on the surface of hepatocytes, which were obtained from the liver specimens of patients that received hepatectomy, were used as predictors of liver dysfunction after majo...