Sentences with phrase «as homologs»

«This reaction is interesting as close relatives of this protein, known as homologs have also been found in animals — ranging from invertebrates like the horseshoe crab to humans — where they play a role in the defence against bacteria,» continues Künzler.

Not exact matches

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

The proteins were selected because the same (homolog) proteins exist in the human brain as well.

It also has a homolog in humans, known as arginine vasopressin.

A mutation in one of the genes that controls this pathway, PTEN (also known as phosphatase and tensin homolog), can cause a particular form of autism called macrocephaly / autism syndrome.

The protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop.

To map the active regions in the brains of the Japanese honeybee workers during the formation of a defensive bee ball, we intended to use the kakusei homolog as a neural activity marker.

He investigates the chaperones and heat shock proteins (Hsp) found in yeast and mammalian cells (as well as their Escherichia coli homologs) using structural, biochemical, and cell biological methods.

Phosphatase and tensin homolog (PTEN): Adding an extra copy of the tumor suppressor gene PTEN to mice produces lower rates of cancer, much as expected, but also increased life span.

Extensively expressed in animals, they were found in several bacteria, especially the homolog from the cyanobacteria Gloeobacter violaceus (GLIC) which functions as a proton-gated ion channel.

We define phylogenetic strata as the deepest node in the branch at which at least one detectable homolog is present, where a detectable homolog is defined as a blastp hit where the alignment covers at least 50 % of the shorter protein with at least 30 % positives.

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.

1), sea anemone Boule1 was used as the Boule homolog sequence.

New Boule and Dazl homologs we have identified as well as known homologs from previous publications are summarized in Table S3.

The identified homologs were verified by BLASTing against the human protein database, which should identify human BOULE as the top hit sequence with highest similarity.

CHICAGO — The protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop.

Regarding deuterostomes, previous studies on the origin of the notochord focused on the hemichordate stomochord, an unpaired chordoid outpocketing of the pharynx, as a possible notochord homolog (27).

Since the nematode Boule homolog is only required for ovarian function but not male gametogenesis, and Boule transcripts have been detected in the ovaries as well as in the testes of some other species [53], [57], [59], we wondered if such ovarian expression in sporadic species is a lineage - specific phenomenon or if it is a common feature.

For example, clusters containing genes that are upregulated during the course of ES cell differentiation (Table 3) include in order of time of expression: cluster 30 that represents genes which take part in the formation of the three embryonic germ layers during gastrulation, i.e., Goosecoid, Cerberus like 1 homolog, Wnt3, Mesp1, Mixl1, mEomes and Even - skipped 1; cluster 15 containing molecular regulators of early mesoderm development including Bmp2, Bmp5, Msx1, Msx2, Cripto, Tbx20, Hey2, Smad6, Vegfr2 (Kdr), Foxf1 and Hand1; cluster 20, which comprises regulatory and structural genes linked to hemopoiesis such as Gata1, Nfe2, Klf1, Tie1, hemoglobins (Hba - x, Hbb - b1) and Glycophorin A; cluster 12, which is rich in genes involved in cardiac development, e.g., Mef2c, Myl4, cardiac Troponin T2, Tropomodulin 1, myosin binding protein C, Bves, Angiopoietin 1 and Angiopoietin 2; and, cluster 4, which consists mostly of genes associated with neuronal development and differentiation, for example, Neurog1, Neurog2, Olig2, Nkx6.1, Neurod4, Pou3f2, Pou3f4, Cacna2d3, Cacng4, Kcnq2 and EphA5.

Upon engraftment into the medial prefrontal cortex in rats, the homolog of the human anterior cingulate cortex, the cells assumed neuronal morphologies, expressed monoaminergic - specific proteins, and seemed to functionally integrate, as assessed by the upregulation of the immediate - early gene, cfos.