Sentences with phrase «as hypermethylation»

Not exact matches

In breast cancer, several known cancer genes, such as BRCA1 and CDH1 (E-cadherin) are commonly silenced by hypermethylation.

Previous research has identified excessive methylation of DNA, or «hypermethylation,» as a ubiquitous aspect of cancer development.

In mouse embryo fibroblasts (MEFs)[2], as well as in the PCa cell lines [unpublished data], DAXX represses expression of these genes via mechanisms that include its binding to DNA methyl transferases (DNMTases) and hypermethylation of the promoter regions of the corresponding genes [2].

But Spector argues that EpiTwin has already made valuable contributions — for example, through a study of 15 twin pairs discordant for breast cancer that pointed toward hypermethylation of the DOK7 gene, which he believes could one day be used as a biomarker to help identify women at risk for breast cancer years in advance.

The paper gives us essentially no evidence at all as to what causes hypermethylation of RXR - alpha in the womb, except that it correlates with low carbohydrate consumption in the women of Southampton UK.