Plant and animal tissues start off
as immature cells called stem cells.
Not exact matches
Newborns become jaundiced in the first few days because the enzyme in the liver maybe
immature and does a process of breaking down these red blood
cells as rapidly.
Smell neurons begin
as identical precursor
cells,
immature cells that have not yet «decided» which type of nerve
cell they will become.
In 1868, however, the German pathologist Ernst Neumann discovered
immature precursor
cells in bone marrow, which turned out to be the actual site of blood
cell formation, also known
as hematopoiesis.
That ovarian tissue bears clusters of
cells known
as primordial follicles, which surround
immature precursors to egg
cells.
The human brain consists of thousands of different types of nerve
cells that are all formed out of what in simple terms can be described
as immature stem
cells.
For the technology to help restore sight in people, such
as those with macular degeneration, the researchers needed to come up with a ready source of
immature retinal
cells.
As «
immature» somatic
cells, stem
cells can mature into different types of
cells, thus making them responsible for the development of all the tissues and organs in the body.
As expected, only the
immature stem
cell type was identified in such pre-implanted embryos, which indicates that the antibodies are highly specific.
When Sukumar and the others depleted the HOXA5 protein in other breast
cell lines in the lab, the
cells became more
immature, or «stem like,»
as well
as more mobile.
«These
immature myeloid
cells appear
as a main source of circulating suPAR,» says Jochen Reiser, MD, PhD, principal investigator and senior author of the study presented in Nature Medicine, who has been working on solving the mysteries of suPAR for more than a decade.
Now, researchers at The Wistar Institute have discovered how STAT3 behaves in
immature myeloid
cells known
as myeloid - derived suppressor
cells (MDSCs), and they believe they have found the basis for a much more effective method of using STAT3 inhibitors to stop cancer progression in its tracks.
The specific type of
cells the researchers in the new Nature Medicine paper looked at, and identified
as giving rise to suPAR, are bone marrow GR - 1lo, Sca1 +
immature myeloid
cells.
These mice have their hemoglobin genes removed and replaced with the mutated human version, saddling them with many of the same problems
as human sufferers, including
immature, short - lived, and sickle - shaped red blood
cells; anemia; reduced blood flow; and an enlarged spleen.
In a quickly executed study that reflects the global public health threat posed by Zika, the researchers compared Zika's effect on
cells known
as cortical neural progenitor
cells to two other
cell types: induced pluripotent stem
cells and
immature neurons.
In terms of mechanism, the authors found that the presence of H. hepaticus, even
as it triggers inflammation via Th17
cells, also indirectly turns on genes that instruct
immature precursor T
cells to become Tregs.
The researchers also found that patients did respond less to Gleevec therapy if they were in a high - risk category due to such factors
as an enlarged spleen or a high percentage of
immature white
cells in their blood.
Stem
cells found in the blood and bone marrow are
immature cells that develop into red and white blood
cells, platelets and additional stem
cells (they are not the same
as embryonic stem
cells).
Overall, the study found, older and younger brains had similar numbers of «intermediate» progenitor
cells and «
immature» neurons — signaling that older people had a similar capacity for generating new
cells as young people.
These
immature cells go through various stages of development before they become fully developed blood
cells and are released into the blood
as:
Gage and Ghosh discuss how human skin
cells induced to return to an
immature state («induced pluripotent stem
cells» or IPS
cells) are revolutionizing our understanding and treatment of mental and neurodegenerative disorders, such
as Parkinson's disease,
as well
as leading to new models of drug development for all diseases.
Specifically, we're focused on stem
cell maturation — taking a
cell from an
immature to a more mature state so that it acts
as a better substrate for adult tissue functions.
During period of ten days or longer,
immature fat
cells, known
as preadipocytes, undergo several stages to turn into adipocytes, or mature fat
cells.
Since this disorder does not stop the production of red blood
cells, there are usually
immature red blood
cells in the bloodstream which can be detected on the blood smears
as well (a regenerative anemia).
Tests may include a reticulocyte test to detect the number of reticulocytes (
immature red blood
cells) that are present in the bloodstream, antibody tests such
as a Coombs test, or serologic blood tests to detect Feline Leukemia, FIV or parasitic diseases such
as Mycoplasma haemofelis.