Sentences with phrase «as in mouse models of the disease»

These plaques are extracellular aggregations of a small protein called beta - amyloid that are prominent in diseased patients» brains, as well as in mouse models of the disease.

Not exact matches

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

The new research investigated the effectiveness of MSC therapy in a mouse model of chronic inflammatory lung disease, which reflects some of the essential features of diseases such as COPD and cystic fibrosis.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse modelIn the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse modelin blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse modelin disease suppression and increased overall survival in mouse modelin mouse models.

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.

-- 90 percent of genes associated with disease are identical in the human and the mouse, supporting the use of mice as model organisms.

The work recently received a $ 1.7 million National Institutes of Health grant to delve into the mechanisms that occur as the cells reprogram, and to employ the cells for treating the Parkinson's - like symptoms in a mouse model of hypomyelinating disease.

Investigating mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaMouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse models phenotyping imaging.

Complementing its extensive capabilities, PsychoGenics offers a variety of validated mouse models including in - licensed transgenic models that support research in areas such as Alzheimer's disease, Huntington's disease, Parkinson's disease, Autism spectrum disorders, psychosis / schizophrenia, Spinal Muscular Atrophy (SMA), muscular dystrophy and other muscle disorders.

And this applies to other areas of the brain as well as the hippocampus, where we are beginning to ask questions about how these areas become dysfunctional in mouse models of Alzheimer's disease.

Such techniques have the potential to enhance research into the origins of neurodevelopmental and neuropsychiatric disorders such as microcephaly, lissencephaly, autism and schizophrenia, which are thought to affect cell types not found in the mouse models that are often used to study such diseases.

Furthermore, new genome - editing technologies such as CRISPR / Cas9 now enable the efficient derivation of precision disease models incorporating patient - specific genetic variants as a means of recapitulating essential aspects of human disease in mouse and other model organisms.

This paper provides direct evidence for the role of TNF in chronic intestinal inflammation using TNBS colitis in Tg197 mice as a model and encourages further clinical trials with anti-TNF therapeutics for the treatment of Crohn's disease.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaMouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse models phenotyping imaging.

Working with Dr. Weiskopf, we established a model of human dengue disease using HLA transgenic mouse strains, and characterized human dengue - specific CD8 + and CD4 + T - cell responses in natural infection as well as following vaccination.

Biomedcode offers preclinical testing using complex mouse models closely recapitulating the complexity of human disease as they also exhibit co-developing pathologies also observed in human patients.

We therefore suggest that the presence of the mutated transgenes (AβPP and PS1), which are per se the basis for the genetic form of Alzheimer's disease in humans, directly interferes with gut function as shown here for the disease model mice.

Curiously, in a mouse model of Alzheimer's disease, PirB serves as a receptor for the beta - amyloid protein that accumulates during the disease.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADIn 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADin dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADin mice contribute to protection vs. ADE.

While not a direct measure of protein degradation, the increased rate of GFAP turnover in mouse models of Alexander disease strongly indicates that degradation is, in fact, increasing as well, says Messing.

Furthermore, the heterozygous knock in mouse serves as a better animal model of the human disorder, as compared to the homozygous mouse, given that Huntington disease homozygosity is very rare in humans.

THE MOUSE MODEL FOR CYSTIC FIBROSIS, as with models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his work.

At JAX's new Alzheimer's Disease Precision Models Center, Howell is genetically manipulating mice to understand how unhealthy lifestyle habits trigger immune responses in the brain, leading to a cascade of events that may ultimately impair thinking and memory, as in Alzheimer's dDisease Precision Models Center, Howell is genetically manipulating mice to understand how unhealthy lifestyle habits trigger immune responses in the brain, leading to a cascade of events that may ultimately impair thinking and memory, as in Alzheimer's diseasedisease.

The Effect of Acetyl - L - carnitine and R - alpha - lipoic acid Treatment in ApoE4 Mouse as a Model of Human Alzheimer's Disease J Neurol Sci 2009 (Mar 31)[Epub ahead of print] We measured age - dependent effects of human ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age - matched wild - type (WT) mice by use of -LSB-(14) C] iodoantipyrene autoradiography.