Sentences with phrase «as key regulators»

Furthermore, there does not need to be a tipping point for these processes and systems in order for them to function as key regulators of the stability of the Earth system.

«Our study focused on a class of enzymes called methyltransferases, which have emerged as key regulators of HIV latency,» explained Melanie Ott, MD, PhD, a senior investigator at Gladstone and lead author of the study published in the scientific journal Cell Host & Microbe.

Hypoxia - inducible factors as key regulators of tumor inflammation.

He served as a member of the graduate faculty in the Department of Molecular Biology at Princeton University and spent 10 years at NIH where he madesignificant contributions to the discovery of a class of proteins known as tyrosine kinase oncogenes as key regulators of the immune system.

The Eischen group focused on the role of long non-coding RNAs (lncRNAs), which have emerged as key regulators of genes.

This led me to enter the field of developmental and cell biology, and to eventually discover cyclin as a key regulator of the cell cycle.

The team has identified the protein kinase MSK1 as a key regulator of dormant or latent metastases.

The new findings come on the heels of a series of pivotal discoveries made by Yuan and colleagues over the last decade revealing RIPK1 as a key regulator of inflammation and cell death.

Researchers from the Vetmeduni Vienna have now discovered that NK cells can switch and promote tumor growth, with STAT5 acting as the key regulator.

Their results, the researchers conclude, identify IL - 28B as a key regulator of the immune response to influenza vaccination.

Additionally, the RBR protein HOIP forms the central unit of the linear ubiquitin chain — assembly complex (LUBAC), which has emerged as key regulator of the NF - κB pathway.

In this presentation, special emphasis will be given to the role of Ca2 + handling as a key regulator of (i) muscle weakness and (ii) beneficial adaptations observed after high intensity interval training.

LKB1 acts as a key regulator of cell polarity as well as energy metabolism partly through the activation of the AMP - activated protein kinase (AMPK), a sensor that adapts energy supply to the nutrient demands of cells facing situations of metabolic stress.

Together, our results identify SCYL1 as a key regulator of motor neuron survival, and Scyl1 -LRB-- / --RRB- mice share pathological features with many human neurodegenerative conditions.

The Sauer group had previously identified ItpkB as a key regulator of immune function.

Subsequent work identified a different protein on the surface of T cells — PD - 1 — as another key regulator of T cell response.

BETHESDA, MD, — The Foundation for the National Institutes of Health (FNIH) has selected Whitehead Institute Member David Sabatini to receive its fifth annual Lurie Prize in Biomedical Sciences for discovery of the mTOR (mechanistic target of rapamycin) cellular pathway as a key regulator of growth and metabolism in response to nutrients.

In the postprandial (fed) state, the insulin receptor plays a positive role as a key regulator of glucose clearance, protein synthesis, etc..

Cellular and Molecular Life Sciences (2017): 1 - 19; Wiley, N. C., et al. «The microbiota - gut - brain axis as a key regulator of neural function and the stress response: Implications for human and animal health.»

She advises many of the key industry participants including Anglo American, Vale, Peabody Energy, Glencore and QCoal, as well as key regulator the Queensland Competition Authority.

Not exact matches

The U.S. Securities and Exchange Commission is examining how private equity firms report a key metric of their past performance when they market new funds to investors, as the regulator boosts its scrutiny of the industry, according to people familiar with the matter.

Financial regulators on both sides of the Atlantic imposed multibillion - dollar fines on five global banks Wednesday as part of investigations into rigging of key foreign exchange markets.

As one of many companies that submitted a written response to regulators last fall, Magna International Inc. indicated its key concerns included potential conflicts of interest, lack of transparency, and potential inaccuracies as well as limited opportunity for issuer engagemenAs one of many companies that submitted a written response to regulators last fall, Magna International Inc. indicated its key concerns included potential conflicts of interest, lack of transparency, and potential inaccuracies as well as limited opportunity for issuer engagemenas well as limited opportunity for issuer engagemenas limited opportunity for issuer engagement.

In 2011, federal and state securities regulators warned investors of the potential risks associated with self - directed IRAs, saying they had noted an increase in complaints about fraudulent investment schemes that used these types of IRAs as a «key feature.»

Although the Chief Justice acknowledged that this argument had some merit, the more determinative factor — and the key difference between the statutory immunity provisions relied upon by the ERCB and Alberta Environment — was that the immunity clause with respect to the former explicitly contemplated the regulator as an entity («the Board or a member of the Board...») whereas the immunity provisions under the Water Act and the EPEA did not (referring only to «persons» in various capacities; see paras 62 — 71).

The aim of the study is to develop key insights for financial institutions and regulators in order to better understand the extent of its impact as they move forward in utilizing blockchain.

A whistleblower is accusing some key financial regulators of allowing sensitive broker information to become readily accessible, even as industry watchdogs emphasized the need for companies to protect client data.

Highlights were policies still claimed by Labour today as among its most significant achievements — the creation of the minimum wage, Scottish and Welsh devolution, and bills to reduce class sizes — as well as one key Brownite policy whose wisdom has now become disputed: independence for the Bank of England, which also involved removing its role as City regulator.

«Science is still the key strength, but on the more commercial end of the business there is a need for people who can engage with the payers and are comfortable in dealings with regulators, health technology assessment bodies such as NICE [the UK's National Institute for Health and Clinical Excellence], clinicians, and patient groups.»

Partly related to its function as a regulator of the immune response, the NF - kB pathway is also a key regulator of cancer progression.

As Dr. Walentin and Professor Schmidt - Ott have now shown, this regulator plays a key role in the development of the placenta.

Sifting through this mountain of data, the scientists found three key genes that were altered by the NOTCH1 mutation and also acted as master regulators, turning off the critical pathways that normally prevent inflammation and calcification.

A team of researchers led by Tokyo Medical and Dental University (TMDU) previously found that upon the onset of lactation after birth, milk lipids serve as a ligand to activate the nuclear receptor peroxisome proliferator - activated receptor (PPAR) α, which is a key transcriptional regulator of liver fat metabolism.

Using newly discovered information, the researchers made significant advances in developing a family of drug candidates that target a receptor known as peroxisome proliferator - activated receptors gamma (PPARγ), a key regulator of stem cells controlling bone formation and bone resorption and a master regulator of fat.

To start the process, both the key regulator Atg1 as well as the «waste» to be discarded are separately brought to the precise location where the waste is packed into cellular «garbage bags.»

Combined with the fact that human skin holds more than 100 times as much sodium than most other ions, led the researchers to believe that the body's sodium regulators were key components.

We discovered STK38 as a novel binding partner of Beclin1, a key regulator of autophagy.

«It is in the spirit of common purpose that we express our disappointment that the Department has apparently chosen not to make this review — which as outlined in your memo has the potential to upend energy markets around the country — public and open to input from industry, grid operators, state regulators, and other key stakeholders.»

One mechanism is protein synthesis by key regulators such as S6 kinase (S6K).

Title: A genome - wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation (IN PRESS, Oct 2012) Authors: Sharrocks A, Yang S - H, Kalkan T, Haslam C, Smith A Date: IN PRESS, Oct 2012 Publication Details: PLoS Genetics

Nucleic acids are not only key molecules for the storage, replication and transcription of genetic information, but also serve as enzymes or regulators of a number of cell processes.

As shown in 1A, similar to hESCs, hNSCs express high levels of SOX2, which is considered a key regulator of pluripotency [19], and NESTIN, a protein specific to NSCs [21]--[23].

So, therefore, insulin is a key regulator of this pathway as well.

These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR endosomal sorting and a new factor in type - I IFN - induced JAK / STAT signalling and gene transcription.

The results also established a hierarchy within the key pluripotency factors such that Klf4 serves as an upstream regulator of feed - forward circuits involving Oct4, Sox2, Nanog and Myc.

DUBAI / / Samples of UAE camel milk have been approved as safe by European regulators in a key step towards starting exports to the continent.

Iodine is by far the most important mineral for understanding thyroid function, since it is not only a key component of all thyroid hormones but also serves as a regulator of thyroid function.

Other areas of the current criteria are also being questioned, such as qualifications in Key skills having to use the assessment models specified by regulators.

We accomplish this by: 1) re-routing service activities to available locations across the country; 2) relocating impacted businesses to recovery locations, as needed; 3) designing our technology and systems to support the recovery processes for critical business functions; 4) designating a crisis management team and recovery leaders responsible for activating and executing on the business continuity plan; and 5) adopting a communication plan to ensure that relevant updates are provided to our employees, customers, regulators and other key stakeholders.

Virtually every other key policy role was filled by environmental regulators — former Environmental Protection Agency (EPA) head Carol Browner as climate czar, former Browner aide Lisa Jackson as EPA administrator, and Nancy Sutley as chair of the White House Council on Environmental Quality.