Sentences with phrase «as liver dysfunction»

Not exact matches

The scientists saw these enlarged nuclei in the liver as well, and the mice developed liver dysfunction.

Telomere dysfunction — alterations in the structure and / or functioning of telomeres — is one of the molecular mechanisms underlying a number of age - related diseases but, to date, little is known about its possible role in pathologies of the liver such as cirrhosis, hepatitis and liver cancer.

Flow cytometric analysis of asialoglycoprotein receptor (ASGPR) levels on the surface of hepatocytes, which were obtained from the liver specimens of patients that received hepatectomy, were used as predictors of liver dysfunction after majo...

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

While you may not always drink to excess, frequently crossing the line still puts you at a greater risk for developing many of the health problems associated with excessive drinking, such as cardiovascular disease (heart disease, hypertension, peripheral vascular disease, stroke and arrhythmias), liver and kidney dysfunction, pancreatitis, and osteoporosis.

You may suffer from physical ailments such as headaches, back and joint pains, anger; psychological traumas such as depression, anxiety, and other mental health illnesses; and liver dysfunctions, all of which cause discomfort and sickness.

Serious liver and kidney problems are well - documented, as are erectile dysfunction, depression and insomnia.

As we shower or bathe, we inhale chloroform, which has been linked with central nervous system disorders and liver dysfunction.

And so I'm really glad that he brought up that point because liver dysfunction, fatty liver, whatever you wan na call it, which, again, when you look at yours Ben, you know, when you consider that the low T3, the conversion as well, that also is likely happening in the liver.

Long - term health problems such as liver damage, sexual dysfunction, and ulcers typically result from chronic or acute consumption.

If this continues, it can progress into liver dysfunction and diseases such as steatohepatitis, cirrhosis or liver scarring, fibrosis, or even liver cancer.

In rat studies, naringin also has the potential to retard as well as improve diabetic complications by improved glucose intolerance, plasma lipid concentrations, and liver mitochondrial dysfunction [6].

Recent decades have seen a dramatic increase in the incidence of physical problems like arthritis, chronic fatigue, diabetes, cystitis, kidney and liver disease and thyroid dysfunction, in addition to which pets today are also more vulnerable to emotional and behavioral problems such as depression and anxiety.

It can't be predicted what mechanism is preferred by the body individually, at any given moment in time; instead of using alkalizing minerals, it can, say, retain more of highly alkaline ammonia, from breaking down proteins, as acid buffer, which could give to your sweat characteristic pungent smell; or it can use ammonia only after it runs out of alkalizing minerals, like calcium; note that buildup of ammonia can also result from liver or renal dysfunction.

11) Sexual Dysfunction: Sluggish biliary function can cause a decrease in overall sex hormone balance as the liver metabolizes the steroid hormones estrogen, testosterone and progesterone.

Here are some of the benefits Liver Balance Plus users report: 93 % reduced stress 92 % higher energy 89 % mood elevation 89 % feeling calmer and more relaxed 85 % reduced or no headaches 83 % less muscle or joint pain 82 % eye or vision improvement 80 % relief from skin irritation 76 % enhanced mental clarity 74 % less congested (sinus and chest) 50 % improvement with skin conditions such as age spots, improved repair of liver dysfunction, relief from constipation, improved gall bladder function, faster healing, stronger immune system, and overall improved state of heLiver Balance Plus users report: 93 % reduced stress 92 % higher energy 89 % mood elevation 89 % feeling calmer and more relaxed 85 % reduced or no headaches 83 % less muscle or joint pain 82 % eye or vision improvement 80 % relief from skin irritation 76 % enhanced mental clarity 74 % less congested (sinus and chest) 50 % improvement with skin conditions such as age spots, improved repair of liver dysfunction, relief from constipation, improved gall bladder function, faster healing, stronger immune system, and overall improved state of heliver dysfunction, relief from constipation, improved gall bladder function, faster healing, stronger immune system, and overall improved state of health.

These illnesses include cancers of virtually every organ system of the body, as well as leukemia, liver disease, pulmonary damage, anemia and blood changes, nervous system disease, immune system damage, psychological damage, reproductive and fertility impairment, and kidney dysfunction.

Particularly, the nutritional deficiencies include choline, vitamin D, zinc and vitamin E, «which could result in significant health problems such as immune dysfunction, accumulation of fat in the liver and musculoskeletal abnormalities,» PawNation reports.

You may be advised to have pre-operative bloodwork done prior to surgery, as this will help to determine if any underlying bleeding disorders or illnesses such as kidney or liver dysfunction exist, to make complications less likely.

As dogs and cats age; their risk for diabetes, heart disease, dental disease, and liver and kidney dysfunction increase, among other possible ailments.

It is important that the steroids are administered with care; in some dogs, the lengthy administration of prednisone may lead to serious side effects such as kidney failure or liver dysfunction.

A multitude of health problems can be significantly managed on special diets, ranging from food allergies, skin problems, dental disease, gastrointestinal disorders, metabolic diseases such as hyperthyroidism or diabetes mellitus, kidney and lower urinary tract diseases, liver diseases, weight management, joint pain, stress, and cognitive dysfunction («dementia»).

In older dogs, cutaneous histiocytosis is rare but may be a sign of underlying diseases such as diabetes, liver dysfunction, or cancer.

This can lead to an abnormal accumulation of excessive copper in the liver known as copper storage hepatopathy, leading to hepatic dysfunction and scarring (cirrhosis).

Instead, cats with this form of the disease may have clinical signs typically associated with impairment affecting an internal organ or system, such as kidney or liver failure, neurologic dysfunction, and ocular disease.

Left untreated, periodontal disease may lead to infection and abscessation of teeth and roots, as well as secondary infection and / or organ dysfunction of the heart, liver and kidneys.

Organ failure Weight loss commonly occurs in response to dysfunction or failure of a vital internal organ such as the heart, liver, or kidneys.

Blood work will likely be done to see if your pet has complications such as clotting problems, low glucose, and kidney or liver dysfunction or electrolyte imbalances.

Clinical signs include fever, loss of appetite, vomiting, shivering, and muscle tenderness, as well as liver and kidney dysfunction.

In human healthcare, preventive medicine is a very important tool for detecting underlying disease such as diabetes, heart failure, and liver dysfunction.

Steer clear of most sugar - free goodies too as many contain xylitol, an artificial sweetener that can cause dangerously low blood sugar and liver dysfunction if consumed by your pet.

If you and your vet can rule out any external factors (e.g. pesticides) causing the constipation, or if it is not secondary to other deeper diseases or health problems such as worms or prostate disease, then chances are it is a cumulative effect of liver or gallbladder dysfunction.

Felitti and colleagues1 first described ACEs and defined it as exposure to psychological, physical or sexual abuse, and household dysfunction including substance abuse (problem drinking / alcoholic and / or street drugs), mental illness, a mother treated violently and criminal behaviour in the household.1 Along with the initial ACE study, other studies have characterised ACEs as neglect, parental separation, loss of family members or friends, long - term financial adversity and witness to violence.2 3 From the original cohort of 9508 American adults, more than half of respondents (52 %) experienced at least one adverse childhood event.1 Since the original cohort, ACE exposures have been investigated globally revealing comparable prevalence to the original cohort.4 5 More recently in 2014, a survey of 4000 American children found that 60.8 % of children had at least one form of direct experience of violence, crime or abuse.6 The ACE study precipitated interest in the health conditions of adults maltreated as children as it revealed links to chronic diseases such as obesity, autoimmune diseases, heart, lung and liver diseases, and cancer in adulthood.1 Since then, further evidence has revealed relationships between ACEs and physical and mental health outcomes, such as increased risk of substance abuse, suicide and premature mortality.4 7

Recent retrospective and prospective studies have identified strong associations between cumulative traumatic childhood events, such as child maltreatment and family dysfunction, and adult physical disease, such as adult heart disease, liver disease, autoimmune diseases and sexually transmitted infections.36 - 41 Mental health disease and the use of psychotropic medications are also greater in adults who had been maltreated as children.42 - 45