Sentences with phrase «as markers of disease»

The advanced glycation end products and lipid peroxidation products are ubiquitous to diabetes and Alzheimer's disease and serve as markers of disease progression in both disorders.

Expression of RANKL / RANK / OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation.

Not exact matches

Think of people declining to get tested for the genetic markers of a hereditary disease, or a smoker whose cigarette packs might as well have that warning from the Surgeon General printed in invisible ink.

In a description of a sleep disorder known as RBD, in which patients enact their dreams through movement, he notes that a deficiency of dopamine (a specific brain neurotransmitter) is one key marker of Parkinson's disease.

In its research — both with healthy people and those suffering from chronic disease, such as irritable bowel syndrome (IBS), diabetes or cardiovascular diseases, the results have all been similar: markers of chronic disease have improved with a KAMUT ® brand grain diet compared to modern wheat.

As well, many other gene markers for grain - mediated injury have been described, thus placing many into the category of gluten intolerant, but not truly having celiac disease.

so often they just look at potential markers — but those don't always equate to diseases)- what was the health of the those being studied - I'm assuming the test subjects were people, but other studies done on animal subjects might not be as reliable as those done on humans.

«Breastfeeding seems to be cardioprotective in these women, as evidenced by improved cholesterol and markers of subclinical cardiovascular disease.»

If your child has a lot of these spots that are larger than a quarter, you should discuss it you're your child's pediatrician as it can be a marker of other diseases.

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

The team's laboratory research will also focus on expanding the sensing capability of the bandage to other treatment - related parameters — such as pH, bacterial load, oxidative states and specific disease markers — and incorporating an on - demand drug release capacity.

The company wanted to use it as a diagnostic marker for disease: If synthetic versions of antibodies could be tagged with aequorin in the lab, then whenever they matched up with an antigen (or surface protein) of a specific pathogen in blood or tissue, the sample would glow.

«It's good to see this type of study advance, as we desperately need noninvasive and low - cost markers for Alzheimer's disease,» Hendrix says.

«Black children were slightly older at the first admission than white children, which could represent a subtle marker of diminished access to medical care or a delay in disease recognition,» said Dr. Dotson, who explained other studies have shown that the role of biology in health disparities in chronic diseases is often modest, and there are many other factors, such as access to care and health literacy, that contribute to disparities in care.

Smith says her group is investigating whether PET imaging of serotonin could be a marker to detect progression of disease, whether alone or in conjunction with scans that detect the clumping protein known as amyloid that accumulates in the brains of those with Alzheimer's disease.

«We hope that our work will provide the basis for a larger study of patient samples that may ultimately identify biomarkers that can be used as surrogate markers to determine the benefit of therapeutic interventions in diagnosed but asymptomatic HD patients to prevent or delay disease onset.»

The researchers analyzed how the changes affected indicators of cardiovascular health, such as blood pressure, heart rate and other markers for heart disease and stroke, like high «bad» cholesterol levels.

Although tau imaging is still in its earliest stages, Ryan hopes that such imaging will accelerate drug development and that finding a blood - based biomarker for Alzheimer's to reveal risk (much like cholesterol serves as a marker for cardiovascular risk) will change the field dramatically in terms of how doctors can diagnose the disease.

The concentration of these components can be a differentiating marker between certain bowel diseases and their accurate detection by way of non-invasive devices such as the electronic nose would be a great step forward for the detection and monitoring of the evolution of these diseases,» explains doctor Pilar Nos, Head of the Digestive System Medicine Department at La Fe hospital.

«This opens a new door in identifying biological markers for dementia since we might consider using the brain's processing of speech sounds as a new way to detect the disease earlier,» says Dr. Claude Alain, the study's senior author and senior scientist at Baycrest's Rotman Research Institute (RRI) and professor at the University of Toronto's psychology department.

As a result, the emphasis in early development is on understanding the molecular underpinnings of disease and developing markers for therapeutic effects.

These discoveries build upon previous findings about genes linked to Alzheimer's, such as the APOE - 4 gene, which is a powerful marker for late - onset Alzheimer's disease; about 40 percent of those diagnosed have this DNA variant.

«Our findings show that a specific genetic marker (known as allele * 2 of the HS1, 2 A enhancer region) influences not just disease activity in RA patients, but also response to therapy in the early stages of their disease,» said lead investigator Dr Gabriele Di Sante of the Institute of Rheumatology and Related Sciences, Catholic University of the Sacred Heart, Rome, Italy.

As Maurizio Battino, researcher at UNIVPM and Director of the study, said: «This is the first time a study has been published that supports the protective role of the bioactive compounds in strawberries in tackling recognised markers and risk factors for cardiovascular diseases.»

Indeed, low birth weight, a marker of impaired fetal development, is associated with increased everyday levels of inflammatory markers as well as greater risks of heart disease, diabetes, depression and schizophrenia in adults.

With additional research and knowledge, she said, it may also be possible one day to use these epigenetic changes as markers, which can tell that a child is at risk of obesity and other diseases.

The authors suggest minimal residual disease status may be a marker of long - term survival outcome and the assessment of minimal residual disease status after treatment should be considered as an end - point in clinical trials.

By providing clues to the function of proteins, he says, the Atlas may accelerate their use as markers for disease or drug targets.

And, given the wide applicability of electrochemical detection to many types of biomolecules, the platform «can be readily extended to the detection of other disease markers such as proteins, metabolites, ions, and nucleic acids,» Liu added.

Two proteins, which have not previously been linked to pre-eclampsia risk, were shown to be at least as good a predictor of disease risk as the current best marker, placental growth factor,.

Doctors measure levels of triglycerides as a marker of heart disease risk, though whether these fats play a role in causing plaque to build up in arteries historically has been a matter of debate.

«Our ability to pinpoint CRP levels as being significantly elevated before and after postoperative delirium onset establishes CRP as a risk marker, as well as a disease marker, for delirium,» said Sarinnapha Vasunilashorn, co-first author of the study, along with Simon Dillon, also of BIDMC.

«The distinct neural markers associated with cognitive performance and GWI revealed in our study can be useful for future research to objectively measure the efficacy of treatments for GWI as well as other brain disorders related to the same neurotransmitter system, like Alzheimer's disease.»

A selection of Joe Davis's colorful «prayer flags,» which are printed with the code for the genetic markers of diseases such as cancer, Parkinson's and Huntington's.

Of course, biochemical markers that flag disease, such as high cholesterol, already exist, but they are not sufficient.

These findings also suggest that other microRNAs may also be important markers of severity for other neurological diseases such as Parkinson's disease and Alzheimer's disease.

Second, fibrosis is a marker of progression to chronic kidney disease, suggesting that the paracrine effects could act as preventative therapy for other serious ailments.

These recommendations are based largely on a body of research that links higher sodium intakes to certain «surrogate markers» such as high blood pressure, an established risk factor for heart disease.

A type of antifungal antibody, called ASCA, is widely used as a diagnostic marker since it is highly elevated in the blood of patients with several chronic diseases including Crohn's.

A protein known as suPAR has been identified in recent years as both a reliable marker for chronic kidney disease and a pathogen of the often deadly condition.

These so - called genome - wide association studies have turned up hundreds of genetic markers linked to diseases such as cancer and diabetes.

As with other genetic studies linking diseases to DNA markers, her research tends to compare populations who have one variation of a genetic marker with those who have a different variation — a comparison that has limited application to individuals.

«Tau aggregates to form the hall - mark tangles of Alzheimer's disease and serves as the best marker of disease progression.

The researchers note that CD8 + T cells could potentially be used as markers for the progression of fatty liver disease, which is expected to become the leading indication for liver transplantation within the next one or two decades.

These findings also suggest that other microRNAs may also be important markers of severity for other neurological diseases such as Parkinson's and Alzheimer's.

Rats born of hypoxic pregnancy with no vitamin C treatment showed increased thickening of the walls of the aorta — up to 170 % above normal — and molecular markers of disease, such as an increase in the heart's heat shock proteins, a signal of cardiac oxidative stress.

The research ideas you develop at the workshop should: • Lead to the significant advancement of our understanding of sensor technologies suitable for liquid biopsy • Consider the practical challenges of low volume liquid usually taken for analysis and the inconsistency of sample preparation across point of care sites • Prioritise biomarkers with high specificity for cancer or even for multiple cancer types, including markers specific to cancers that will become aggressive as opposed to non-lethal disease

Human geneticists and cardiologists studying families with heart disease may discover, said Stainier, that a mutated form of the gata5 homologue occurs in some cases of heart disease, in which case the mutated form of the gene could serve as a marker of predisposition to the disease.

In collaboration with data - sharing networks, namely MalariaGEN and STOP - HCV, they are using genetics as a tool to investigate the underlying biology of infectious diseases and to identify genetic markers that correlate with clinical outcomes.

Gata5 a potential diagnostic marker for congenital heart disease The finding also suggests that gata5 could be a potential new diagnostic marker for congenital heart defects, as the researchers demonstrated that gata5 regulates the expression of a gene known as nkx2.5 which, when mutated in humans, causes human congenital heart defects and disease.