Sentences with phrase «as mechanisms of resistance»

Similar approaches could be used to study the molecular basis of response to a given therapy, as well as mechanisms of resistance to treatment.

Not exact matches

«We are trying to shape the view of diastolic dysfunction to include flow patterns as a mechanism that modulates the chamber's resistance to filling — in addition to the wall's own stiffness,» said del Alamo.

«Here, we show that the BRAF inhibitors induce autophagy as a way to escape cell death, which gives us clues on how to interfere with this mechanism of resistance and improve outcomes for these patients.»

In order to ensure that future antibiotics retain their effectiveness for as long as possible, it is essential that effective surveillance mechanisms are combined with the use of genome sequencing to scan for the emergence and spread of resistance.»

Further investigations could pave the way to a more complete understanding of the genetics and metabolomics of cell growth in yeast and the underlying mechanisms relevant to other settings in which cells face challenging conditions, such as cancer progression and the evolution of drug resistance.

«Now, because we know the resistance mechanism, we can design elements to minimize the emergence of resistance as these promising new drug candidates are developed,» said Ben Shen, a TSRI professor who led the study, which was published February 20, 2014 online ahead of print by the Cell Press journal Chemistry & Biology.

Heterogeneity in a bacterial population that arises through a mechanism of biased partitioning of drug efflux pumps, as we identified in our study, could be a stepping - stone on the path of bacterial populations towards antibiotic resistance.»

At this stage, there are several hypotheses as to the nature of the mechanism, but it is very likely that Busseola fusca has developed an unconventional resistance mechanism yet to be identified.

Dr Daniel Martin, Senior Lecturer and Honorary Consultant, UCL Division of Surgery and Interventional Science and Director of UCL CASE Medicine, adds: «These exciting results give us a unique insight into the possible mechanism of insulin resistance in diabetes and provide some clues as to where we should be thinking about focusing further research on novel treatments for this disease.

The research, led by the University of Southampton and UCL, which took place on Mount Everest, assessed the mechanisms by which low oxygen levels in the body — known as hypoxia — are associated with the development of insulin resistance.

Drs. Baughn and Minato hope that the understanding of mechanisms for synergy will lead them and others to more potent drug combinations that can be deployed in the fight against pathogenic microbes as drug resistance becomes increasingly commonplace.

First, we produced PARP1 - KO ovarian cancer cell lines using CRISPR / Cas9 gene editing to test the loss of PARP - 1 as a resistance mechanism to all clinically used PARP inhibitors.

New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.

First of all, it seems that biodiversity may not offer as much protection if the event in question is very extreme: buffering mechanisms which drive ecosystem resistance, such as compensation by better - adapted species or species taking over the functional role of others (functional redundancy), may simply be overwhelmed in such cases.

The Use of Antimicrobials as Adjuvant Therapy for the Treatment of Obesity and Insulin Resistance: Effects and Associated Mechanisms — Sandra Aparecida dos Reis — Diabetes / Metabolism Research and Reviews

She started her scientific career as an undergraduate and then PhD fellow at the Pasteur Institute, Paris, France, uncovering the molecular basis of IFN - induced OAS proteins in mediating resistance to West Nile virus infection and characterizing the molecular mechanism of action of DC - SIGN surface lectin polymorphisms that associate with severe Dengue hemorrhagic fever.

In 2007, he joined Columbia University as a post-doc, where he developed network - based computational approaches aimed at identifying key drivers of initiation and progression of cancer, as well as mechanisms of therapeutic response and drug resistance.

We seek to «Track and Treat» the cancer cells present in patients» tissues by using lineage tracing, as well as sequencing technologies, to determine the molecular mechanisms responsible for the dissemination of cancer cells to various organs, and resistance to current therapies.

Previosly in a preclinical study BRAF inhibitor - resistant mutated BRAF melanoma cells were developed as an experimental model system to mimic BRAF inhibitor - resistant melanoma patients and to study the mechanisms of resistance.

His research interest focuses on 1) development and application of TALEN and CRISPR technologies for targeted genome editing in plant species, and 2) molecular mechanism of plant / microbe interactions and crop disease resistance engineering by using the bacterial blight of rice as a model.

Among other things, we have identified one mechanism of multi-drug resistance (MDR) involving P - glycoprotein (Pgp) which functions as a drug efflux pump of broad specificity.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

The project has the potential to provide important new information about mechanisms of drug resistance in melanoma - a key medical problem - as well as to evaluate the potential of splicing inhibitors as a therapeutic approach in two groups of melanoma pts with different response kinetics.

Kulkarni A, Al - Hraishawi H, Simhadri S, Hirshfield KM, Chen S, Pine S, Jeyamohan C, Sokol L, Ali S, Teo ML, White E, Rodriguez - Rodriguez L, Mehnert JM, and Ganesan S. BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAFV600E Mutant Melanoma.

As a result, we are finding similar mechanisms of resistance.

These results show that acquisition of a JAK inhibitor - resistant mutation such as the Y931C in cells dependent on activated JAK2 V617F for growth is a potential mechanism of secondary resistance to JAK inhibitor therapy in MPN patients.

«In our model, stress conditions, such as a genetic variant or insulin resistance or a high - fat diet, lead to increased availability of the tribbles protein by as yet poorly understood mechanisms,» says Dr. Kulkarni, who is also an Assistant Professor of Medicine at Harvard Medical School.

The role of gene regulation in C. auris drug resistance mechanisms and host interactions — such as overexpression of ERG11 and other known fluconazole resistance genes — are currently unknown.

From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.

Here, we report the first mechanistic description of talazoparib resistance, the first BRCA2 reversion mutations identified in prostate cancer, and the first cases of multiclonal BRCA2 reversion mutations as a mechanism of PARPi resistance.

These results show that acquisition of a JAK inhibitor resistant mutation such as the F958C in cells dependent on activated JAK1 for growth is a potential mechanism of secondary resistance to JAK inhibitor therapy.

In this condition, vascular cells could become dysfunctional because of hyperinsulinemia or because vascular cells themselves are insulin resistant, which is caused by increased insulin production from pancreatic beta cells as a compensatory mechanism to overcome insulin resistance.

Recent spread of artemisinin resistance and emerging piperaquine resistance in Southeast Asia show that artemisinin combination therapy, such as dihydroartemisinin - piperaquine, are losing clinical effectiveness, prompting investigation of drug resistance mechanisms and development of strategies to surmount emerging anti-malarial resistance.

Finally, analysis of tumors from clinical trials and cell line models will allow discovery of mechanisms of sensitivity and resistance to AR and PI3K inhibitors, as well as biomarkers that can be used in the development of new treatment regimens and selection of patients for future trials.

Many mechanisms of MDR have been described, such as the overexpression of MDR1 (also known as P - glycoprotein or ABCB1) or other ATP - dependent transporters that pump drugs out of the cancer cells, amplification of drug - inactivating enzymes, mutations or modifications of drug targets, alterations in DNA repair machinery, and increased resistance to apoptosis (1 — 3).

However, as is true of most biological mechanisms, context must be taken into account: acute administration of insulin improves performance on tests of memory and cognition, but chronically elevated insulin levels have the opposite effect.4, 42,43 This is akin to the pathology of T2D, in which normal, acute doses of insulin help regulate glucose uptake, but chronically elevated levels lead to insulin resistance, hyperglycemia, and the attendant inflammation and vascular damage.

Insulin resistance causes chronically high levels of insulin in the body and as said earlier, it's an unconscious mechanism by which insulin can exist at these high levels, even when the need might not be.

The main hypothesis includes a stress preconditioning response mechanism, in which it is believed that periods of nutrient deprivation displays a beneficial mild stress that results in molecular adaptive changes in various tissues, which increases the organism's resistance to bigger stressors such as excitotoxic and oxidative injury, including ischemia (33,71).

So personally, if I already had the disease, and wanted to clean out and retool the cellular machinery as efficiently as possible, I would choose less saturated fat rather than more and leave out the oil, again based on what we know of the mechanisms of saturated fat induced insulin resistance.

The purpose of this manuscript is to discuss the mechanisms and potential benefits of blood flow restricted exercise on bone adaptation and provide rationale as to why low load resistance exercise to failure would be unlikely to produce these benefits.

Viewing insulin resistance as a defensive mechanism of cells helps us see why these dietary changes are so vital to preventing diabetes.

As part of this homeostatic mechanism, the initial response of the body to compensate for decreased MAP is to bring it back up to normal by increasing systemic vascular resistance, by vasoconstriction.

Martin Luther King Jr's famous «Letter from Birmingham Jail» espoused principles that built on Gandhi and Thoreau's conception of civil resistance as a mechanism to achieve true justice (King Jr., Martin Luther, «Letter from Birmingham Jail» (August 1963)[MLK]-RRB-.