Sentences with phrase «as mechanistic target»

Whitehead Institute scientists have at last answered the long - standing question of how the growth - regulating pathway known as mechanistic target of rapamycin complex 1 (mTORC1) detects the presence of the amino acid leucine — itself a key player in modulating muscle growth, appetite, and insulin secretion.

Not exact matches

The mechanistic modelling, treatment of people as resources, obsession with the short - term, and management by targets in the public sector are all symptoms of the sick ideology that has driven management culture, which Simon brilliantly dissected.

To coordinate their size and growth with current environmental conditions, cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway, which senses cellular stresses, growth factors, and the availability of nutrients, such as amino acids and glucose.

Known as much for its complexity as its vital role in regulating cellular and organismal growth, the mechanistic target of rapamycin complex 1 (mTORC1) pathway has seemingly been acting in mysterious ways.

This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.

Whitehead Institute researchers have elucidated how the growth - regulating metabolic pathway known as mTORC1 (for mechanistic target of rapamycin complex 1) senses the amino acid arginine.

BETHESDA, MD, — The Foundation for the National Institutes of Health (FNIH) has selected Whitehead Institute Member David Sabatini to receive its fifth annual Lurie Prize in Biomedical Sciences for discovery of the mTOR (mechanistic target of rapamycin) cellular pathway as a key regulator of growth and metabolism in response to nutrients.