Not exact matches
Earlier on Friday, U.S. health officials published a study estimating that
as many
as 270 babies
in Puerto Rico may be born with the severe birth defect known
as microcephaly caused by Zika infections
in their mothers during pregnancy.
The WHO says there is strong scientific consensus that Zika is a cause of the birth defect
microcephaly, or small heads
in babies,
as well
as Guillain - Barre syndrome, a neurological disorder.
Health officials on Friday reported the first baby born
in New York City with the Zika - related birth defect known
as microcephaly, a condition marked by an abnormally small head and impaired brain development.
Although one of the most serious consequences of the Zika virus (ZIKV)
in infants is
microcephaly, there is a broad collection of anomalies now known
as congenital Zika syndrome (CZS).
As most studies have only carefully examined infants with presumed or confirmed congenital ZIKV infection who have
microcephaly, more studies are needed to understand ocular findings
in those infants with congenital ZIKV infection without
microcephaly.
As we report
in a collection of stories, much remains unclear, including the relationship between Zika infection and
microcephaly and how best to combat the mosquitoes that spread the disease.
Furthermore, the defects observed are specific to an infection by ZIKV,
as other neurotropical viruses of the flavivirus family (West Nile virus, yellow fever,...) did not cause
microcephaly,
in contrast to Zika virus.
Now, it is being deployed to monitor the Zika
as it spreads beyond Brazil, where reports last August of fetal deaths and newborns with brain disorders including
microcephaly, a devastating condition that results
in abnormally small brains and heads, began to trickle
in.
Lahn and his colleagues looked at the abnormal spindle - like
microcephaly associated (ASPM) gene, which scientists had previously identified
as a key player
in brain development.
But the virus has also been linked to an autoimmune disease that can cause paralysis called Guillain — Barré syndrome
as well
as an alarming surge
in a birth defect called
microcephaly in Brazil.
The new report suggests that,
as in Brazil, Zika virus bears blame for Colombia's
microcephaly epidemic too.
There has been a 20-fold increase
in the number of babies born with this condition, known
as microcephaly, since Zika first appeared
in Brazil
in May 2015.
In Brazil, the country hit hardest by the epidemic so far, there have been 6,906 suspected cases of
microcephaly as of April 2, 2016.
It emerged
as an infectious threat
in the Western hemisphere
in Brazil
in 2015 where it made news for creating a spate of birth defects, including the devastating brain anomaly
microcephaly.
As evidence grew for a causal link between Zika infection and
microcephaly and other serious congenital anomalies (1), the World Health Organization (WHO) declared the Latin American Zika epidemic a public health emergency of international concern
in February 2016 (2).
As of March 30, the CDC has reported 312 cases of the Zika virus
in the United States and heightened its efforts
in response to Zika and the cases of
microcephaly and other neurological disorders associated with the virus.
«
As we learn more about the consequences of Zika infection, including the recent revelation that babies of Zika - infected mothers who had normal head sizes at birth have been diagnosed with
microcephaly months later, it is vital that we know this enemy and remain vigilant
in protecting ourselves,» Diaz concludes.
A furious debate ensued: the fossil discoverers classify the meter - tall hominin
as part of a separate species that lived
as recently
as 12,000 years ago; others maintain it was a modern human who had
microcephaly,
in which the brain fails to reach normal size.
MICROCEPHALY MUTATION Scientists may finally understand why the Zika virus was suddenly able to cause
microcephaly,
as seen
in this child
in Salvador, Brazil.
In humans, Zika virus infection during pregnancy has been linked to a suite of birth defects including a condition known
as microcephaly, which leaves babies with shrunken heads and brains (SN: 4/2/16, p. 26).
With its rapid spread throughout Central and South America, Zika has emerged
as a severe health threat that can cause
microcephaly in newborns,
as well
as Guillain - Barre syndrome
in children and adults.
The famous cancer gene BRCA1 may also play a role
in neurodevelopmental disorders such
as microcephaly (right), which causes small brain size.
The U.S. Centers for Disease Control and Prevention recently concluded that Zika virus infection
in pregnant women can stunt neonatal brain development, leading to babies born with abnormally small heads, a condition known
as microcephaly.
Zika was known for 60 years
as a mild virus that appeared sporadically, but since 2007, two troubling shifts have taken place, Dye said: Zika virus now results
in widespread outbreaks of hundreds or thousands of cases, and it is associated with neurological disorders like
microcephaly and Guillain - Barre syndrome, a disorder
in which the body's immune system attacks the nerves.
Roughly four
in every 1000 babies are infected with cytomegalovirus (CMV), which can cause seizures and intellectual disability,
as well
as Zika - like symptoms including
microcephaly.
Satuation of the environment with pesticides, including the drinking water,
in this particular area of northeastern Brazil needs to be studied
as a cause of
microcephaly as well:
In 2015, the Zika virus began spreading throughout the Americas and a potential link was seen between the virus and a significant increase in cases of fetal microcephaly, as well as other neurologic abnormalitie
In 2015, the Zika virus began spreading throughout the Americas and a potential link was seen between the virus and a significant increase
in cases of fetal microcephaly, as well as other neurologic abnormalitie
in cases of fetal
microcephaly,
as well
as other neurologic abnormalities.
We next estimated the maximum number of births potentially affected by ZIKV
in Latin America,
as this region is the focus of the recent outbreak and the first to point to a possible association with
microcephaly in newborn infants to mothers infected with ZIKV.
Zika has been tied to neurological problems
in babies such
as microcephaly, a particularly grim birth defect that results
in underdeveloped brains and small heads.
Such techniques have the potential to enhance research into the origins of neurodevelopmental and neuropsychiatric disorders such
as microcephaly, lissencephaly, autism and schizophrenia, which are thought to affect cell types not found
in the mouse models that are often used to study such diseases.
Researchers have already documented an increase of
microcephaly cases coinciding with the outbreak and have found evidence of the virus
in brains of newborns who died,
as well
as in fluid from the placenta of infected pregnant women.
Although most infants had
microcephaly by head circumference measure, some patients had a measurement that was consistent with their gestational age,
as brain atrophy was compensated by an enlargement
in ventricular size.19
The report demonstrates phenotypic variability
in regard to the presence of observed
microcephaly as well
as the degree of brain damage and affected brain structures with congenital ZIKV infection.
Recife is experiencing an outbreak of ZIKV infection
as well
as an increase
in the number of newborns with
microcephaly.
Contracted through the bite of an infected mosquito or through sexual or other modes of transmission, Zika virus (ZIKV) infection can be prenatally passed from mother to fetus.1 The virus was first identified
in the region of the Americas
in early 2015, when local transmission was reported
in Brazil.2 Six months later, a notable increase
in the number of infants with congenital
microcephaly was observed
in northeast Brazil.3, 4 Clinical, epidemiologic, and laboratory evidence led investigators to conclude that intrauterine ZIKV infection was a cause of
microcephaly and serious brain anomalies.5 - 7 However,
as with other newly recognized teratogens, these features likely represent a portion of a broader spectrum.
Other viruses such
as rubella and cytomegalovirus (CMV) that can trigger
microcephaly when contracted
in the womb also lead to hearing loss
in some cases.
The central nervous system damage seen with prenatal ZIKV infection is likely due to direct cellular injury,
as ZIKV RNA15, 17,32 and live virus15 have been identified
in the brain tissue of infants with
microcephaly.
The disease has been linked to an increase
in miscarriages, deaths
in newborns, and birth defects, especially a condition known
as microcephaly,
in which the brain does not fully develop and babies are born with abnormally small heads.