Historically, researchers have generated their own lines of knockout mice to serve
as models for human disease, such as heart disease or cancer.
Clinicians and investigators in the fields of veterinary and human endocrine oncology, clinical trials, pathology, and drug development will be joined in this consortium, in order to improve knowledge, development of, and access to naturally occurring canine endocrine tumours,
as a model for human disease.
Human medical research by physicians and scientists using the greyhound
as a model for human disease.
Mice hold a very important place
as models for human diseases, including cancer, in biomedical research.
Recently, the section has been involved in collaborative work investigating farm animal conditions
as models for human diseases.
Not exact matches
To better understand their findings, the team examined the animal
model for APS1 (i.e. mice with the same genetic defect
as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory
disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.
With our
human gut - on - a-chip, we can not only culture the normal gut microbiome
for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium,
as well
as model specific
diseases to understand complex pathophysiological responses of the intestinal tract.»
Scientists study VSV, which causes acute
disease in livestock but typically does not lead to illness in people,
as a
model for viruses that are harmful to
humans.
And the enrichments may make the animals better at what they do: serving
as important
models for human disease.
More recently, researchers have induced stem cells from
diseased human somatic cells, which may serve
as new
model systems
for various illnesses.
In recent years, songbirds» similarities to
human vocal learning have piqued researchers» interests in using them
as a functional animal
model to study the neurological basis
for Huntington's
disease.
«Finches offer researchers a new tool with which to study Huntington's
disease: Like
humans, songbirds learn their vocalizations, suggesting they could be useful
as models for certain disorders.»
Like
humans, songbirds such
as zebra finches (above) can learn vocalizations, and this similarity suggests they could serve
as models for research on Huntington's
disease and other neurodegenerative disorders that affect speech and vocalization.
«Using the fruit fly
as a
model [
for a
human disease] is extremely exciting,» he adds.
Given the rapid succession of generations in yeast, we can use it
as a
model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches
for diagnosing and treating
human diseases.»
Findings from mouse
models suggest that eye examination could be used
as a noninvasive screening tool
for human brain
diseases.
She added that, «attempts to generate the cerebellum from
human iPS cells have already met with some success, and these patient - derived cerebellar neurons and tissues will be useful
for modeling cerebellar
diseases such
as spinocerebellar ataxia.»
Williams said that the discovery could be important
for human medicine because the canine
disease may serve
as a
model for human PVOD.
Clevers and other scientists have developed organoids of the gut, liver, lung, brain, and many other
human organs that can be used to
model disease or to serve
as test beds
for drugs.
Investigating mouse
models for biological
for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare
diseases, microbiota and ageing pipeline,
as well
as illustration of examples of scientific projects about «Animal
models for human diseases» and recent developments in mouse
models phenotyping imaging.
This animal
model closely resembles lesion kinetics
as seen in
human disease [34] and use of non-
human primates allows
for repetitive surgical sampling
for multiple time point analysis.
Furthermore, we have seen that they can be employed
for modelling human neurological
diseases, such
as Alzheimer's
Disease.
At longer extend, based on our technical and scientific expertises, this project aims to extend pathological
modelling to others neuro - muscular
diseases, such
as Spinal Muscular Atrophy (SMA)
for which,
human pluripotent stem cells carrying the causal mutation have been derived.
NYSCF partners with a broad range of institutions, foundations, centers and companies in a variety of ways ranging from the creation of fundamental research resources such
as iPSC lines
for a
disease area to developing
human disease models in vitro to enable drug discovery and toxicity testing.
If successful, this
model of making
human genomic data accessible to the world might become a paradigm
for other
diseases,
as a way to catalyze scientific advances throughout all fields of
human biology.
We focus on developing computational methods and tools
for (a) analyzing large - scale gene expression data related to
human cancer in search
for gene markers and
disease sub-categories, (b) identifying regulatory elements such
as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical
models of gene regulatory networks.
Each cell - based treatment approach is presented
as a potential therapy
for a specific
disease or a
disease category (e.g.: cardiovascular
diseases, metabolic
diseases, etc.), studied in animal
models or in
humans.
These mice will be preserved in repositories and made available to the scientific community representing a valuable resource
for basic scientific research
as well
as generating new
models for human diseases.
He later combined it with studies on chromatin, tissue specific gene expression and mouse
models for human diseases including Type II diabetes, polycystic kidney
disease as well
as cancer.
The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare
diseases, microbiota and ageing pipeline,
as well
as illustration of examples of scientific projects about «Animal
models for human diseases» and recent developments in mouse
models phenotyping imaging.
Here we tested whether
human NSCs could be reprogrammed into iPS cells utilizing a similar strategy
as described above since they represent a more clinically relevant source of cells
for basic studies and
modeling human disease.
We therefore suggest that the presence of the mutated transgenes (AβPP and PS1), which are per se the basis
for the genetic form of Alzheimer's
disease in
humans, directly interferes with gut function
as shown here
for the
disease model mice.
We have characterized mitochondrial SRS and, through its mutation, we have generated a Drosophila
model that can be used
as a proxy
for human mitochondrial
disease in a
model system that is easy to manipulate.
Fruit flies serve
as a good
model organism
for understanding the molecular mechanisms behind many
human diseases — around 75 percent of
disease - causing genes are found in the species in a similar form.
Genetically modified goats are an important tool
for producing valuable therapeutic protein [14]--[16] and studying
human diseases as ideal biomedical
models [17]--[19].
«Drosophila
as a
Model for Human Neurodegenerative
Disease,» by Julide Bilen and Nancy M. Bonini, Annual Review of Genetics, December 2005.
The Ellerby lab is known
for its pioneering studies on Huntington's
disease (HD), and Karen is now using
human stem cell
models of HD to understand why important molecular signaling pathways, such
as the TGF - β pathway, are dysregulated in HD.
THE MOUSE
MODEL FOR CYSTIC FIBROSIS, as with models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his wo
FOR CYSTIC FIBROSIS,
as with
models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his wo
for many
diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of
human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine
for his wo
for his work.
I am currently working on a variety of NIH - funded projects, including areas such
as bioinformatics research portals, visualization
for review of chart records, and tools
for aiding the discovery of animal
models of
human diseases.
Gage and Ghosh discuss how
human skin cells induced to return to an immature state («induced pluripotent stem cells» or IPS cells) are revolutionizing our understanding and treatment of mental and neurodegenerative disorders, such
as Parkinson's
disease,
as well
as leading to new
models of drug development
for all
diseases.
For three years now we have been working on
human cell
models of rare neurodegenerative
diseases with special emphasis on neuroacanthocytosis, neuronal ceroid lipofuscinosis
as well
as motor neuron degeneration (using iPS cells).
In his research, Schroeder uses C. elegans, an important
model system
for human disease, to investigate how novel cell metabolism products function
as signals between individuals and within cells.
As each person takes responsibility for their own personal evolution, then human beings as a collective can move beyond the materialistic model and the creation of greater disease state
As each person takes responsibility
for their own personal evolution, then
human beings
as a collective can move beyond the materialistic model and the creation of greater disease state
as a collective can move beyond the materialistic
model and the creation of greater
disease states.
Dog DNA project provides clues to
human illnesses Melbourne researchers are examining the DNA of dogs in a research project aiming at determining the genetic causes of common pet
diseases - and to provide a
model for combating
diseases such
as diabetes and multiple sclerosis in
humans.
In the study, lead author Duncan Lascelles, CVM professor of small animal surgery and pain management, outlines an comprehensive argument
for the translational power of utilizing companion animals with naturally occurring
diseases as models of
human conditions.
The emphasis is on developing intellectual abilities and research skills through investigations of infectious
diseases of food - producing, companion, and aquatic animals,
as well
as animal
models for human disease.
These mutations establish CMR
as a novel animal
model for Best macular dystrophy (BMD) in
humans, an autosomal dominant, childhood retinal
disease also caused by mutations in the Bestrophin gene [76, 77].
The domestic dog is frequently cited
as being an exceptional
model for human inherited disorders due to the number of
diseases identified, similarity in
disease presentation, and population structure in the dog [1].
Dr. Dodds: After years of studying and researching the hematologic and immunologic
diseases of animals
as models for their
human counterparts, I realized that I needed to look more at the body
as a whole and what regulated it.
Current
models of climate change include sea level rise, land degradation, regional changes in temperature and precipitation patterns, and some consequences
for agriculture, but without
modeling the feedbacks that these significant impacts would have on the
Human System, such as geographic and economic displacement, forced migration, destruction of infrastructure, increased economic inequality, nutritional sustenance, fertility, mortality, conflicts, and spread of diseases or other human health consequences [135,
Human System, such
as geographic and economic displacement, forced migration, destruction of infrastructure, increased economic inequality, nutritional sustenance, fertility, mortality, conflicts, and spread of
diseases or other
human health consequences [135,
human health consequences [135,136].