Sentences with phrase «as models for human diseases»

Recently, the section has been involved in collaborative work investigating farm animal conditions as models for human diseases.

Mice hold a very important place as models for human diseases, including cancer, in biomedical research.

Historically, researchers have generated their own lines of knockout mice to serve as models for human disease, such as heart disease or cancer.

Clinicians and investigators in the fields of veterinary and human endocrine oncology, clinical trials, pathology, and drug development will be joined in this consortium, in order to improve knowledge, development of, and access to naturally occurring canine endocrine tumours, as a model for human disease.

Human medical research by physicians and scientists using the greyhound as a model for human disease.

Not exact matches

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

Scientists study VSV, which causes acute disease in livestock but typically does not lead to illness in people, as a model for viruses that are harmful to humans.

And the enrichments may make the animals better at what they do: serving as important models for human disease.

More recently, researchers have induced stem cells from diseased human somatic cells, which may serve as new model systems for various illnesses.

In recent years, songbirds» similarities to human vocal learning have piqued researchers» interests in using them as a functional animal model to study the neurological basis for Huntington's disease.

«Finches offer researchers a new tool with which to study Huntington's disease: Like humans, songbirds learn their vocalizations, suggesting they could be useful as models for certain disorders.»

Like humans, songbirds such as zebra finches (above) can learn vocalizations, and this similarity suggests they could serve as models for research on Huntington's disease and other neurodegenerative disorders that affect speech and vocalization.

«Using the fruit fly as a model [for a human disease] is extremely exciting,» he adds.

Given the rapid succession of generations in yeast, we can use it as a model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches for diagnosing and treating human diseases.»

Findings from mouse models suggest that eye examination could be used as a noninvasive screening tool for human brain diseases.

She added that, «attempts to generate the cerebellum from human iPS cells have already met with some success, and these patient - derived cerebellar neurons and tissues will be useful for modeling cerebellar diseases such as spinocerebellar ataxia.»

Williams said that the discovery could be important for human medicine because the canine disease may serve as a model for human PVOD.

Clevers and other scientists have developed organoids of the gut, liver, lung, brain, and many other human organs that can be used to model disease or to serve as test beds for drugs.

Investigating mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaging.

This animal model closely resembles lesion kinetics as seen in human disease [34] and use of non-human primates allows for repetitive surgical sampling for multiple time point analysis.

Furthermore, we have seen that they can be employed for modelling human neurological diseases, such as Alzheimer's Disease.

At longer extend, based on our technical and scientific expertises, this project aims to extend pathological modelling to others neuro - muscular diseases, such as Spinal Muscular Atrophy (SMA) for which, human pluripotent stem cells carrying the causal mutation have been derived.

NYSCF partners with a broad range of institutions, foundations, centers and companies in a variety of ways ranging from the creation of fundamental research resources such as iPSC lines for a disease area to developing human disease models in vitro to enable drug discovery and toxicity testing.

If successful, this model of making human genomic data accessible to the world might become a paradigm for other diseases, as a way to catalyze scientific advances throughout all fields of human biology.

We focus on developing computational methods and tools for (a) analyzing large - scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks.

Each cell - based treatment approach is presented as a potential therapy for a specific disease or a disease category (e.g.: cardiovascular diseases, metabolic diseases, etc.), studied in animal models or in humans.

These mice will be preserved in repositories and made available to the scientific community representing a valuable resource for basic scientific research as well as generating new models for human diseases.

He later combined it with studies on chromatin, tissue specific gene expression and mouse models for human diseases including Type II diabetes, polycystic kidney disease as well as cancer.

The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaging.

Here we tested whether human NSCs could be reprogrammed into iPS cells utilizing a similar strategy as described above since they represent a more clinically relevant source of cells for basic studies and modeling human disease.

We therefore suggest that the presence of the mutated transgenes (AβPP and PS1), which are per se the basis for the genetic form of Alzheimer's disease in humans, directly interferes with gut function as shown here for the disease model mice.

We have characterized mitochondrial SRS and, through its mutation, we have generated a Drosophila model that can be used as a proxy for human mitochondrial disease in a model system that is easy to manipulate.

Fruit flies serve as a good model organism for understanding the molecular mechanisms behind many human diseases — around 75 percent of disease - causing genes are found in the species in a similar form.

Genetically modified goats are an important tool for producing valuable therapeutic protein [14]--[16] and studying human diseases as ideal biomedical models [17]--[19].

«Drosophila as a Model for Human Neurodegenerative Disease,» by Julide Bilen and Nancy M. Bonini, Annual Review of Genetics, December 2005.

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

THE MOUSE MODEL FOR CYSTIC FIBROSIS, as with models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his woFOR CYSTIC FIBROSIS, as with models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his wofor many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his wofor his work.

I am currently working on a variety of NIH - funded projects, including areas such as bioinformatics research portals, visualization for review of chart records, and tools for aiding the discovery of animal models of human diseases.

Gage and Ghosh discuss how human skin cells induced to return to an immature state («induced pluripotent stem cells» or IPS cells) are revolutionizing our understanding and treatment of mental and neurodegenerative disorders, such as Parkinson's disease, as well as leading to new models of drug development for all diseases.

For three years now we have been working on human cell models of rare neurodegenerative diseases with special emphasis on neuroacanthocytosis, neuronal ceroid lipofuscinosis as well as motor neuron degeneration (using iPS cells).

In his research, Schroeder uses C. elegans, an important model system for human disease, to investigate how novel cell metabolism products function as signals between individuals and within cells.

As each person takes responsibility for their own personal evolution, then human beings as a collective can move beyond the materialistic model and the creation of greater disease stateAs each person takes responsibility for their own personal evolution, then human beings as a collective can move beyond the materialistic model and the creation of greater disease stateas a collective can move beyond the materialistic model and the creation of greater disease states.

Dog DNA project provides clues to human illnesses Melbourne researchers are examining the DNA of dogs in a research project aiming at determining the genetic causes of common pet diseases - and to provide a model for combating diseases such as diabetes and multiple sclerosis in humans.

In the study, lead author Duncan Lascelles, CVM professor of small animal surgery and pain management, outlines an comprehensive argument for the translational power of utilizing companion animals with naturally occurring diseases as models of human conditions.

The emphasis is on developing intellectual abilities and research skills through investigations of infectious diseases of food - producing, companion, and aquatic animals, as well as animal models for human disease.

These mutations establish CMR as a novel animal model for Best macular dystrophy (BMD) in humans, an autosomal dominant, childhood retinal disease also caused by mutations in the Bestrophin gene [76, 77].

The domestic dog is frequently cited as being an exceptional model for human inherited disorders due to the number of diseases identified, similarity in disease presentation, and population structure in the dog [1].

Dr. Dodds: After years of studying and researching the hematologic and immunologic diseases of animals as models for their human counterparts, I realized that I needed to look more at the body as a whole and what regulated it.

Current models of climate change include sea level rise, land degradation, regional changes in temperature and precipitation patterns, and some consequences for agriculture, but without modeling the feedbacks that these significant impacts would have on the Human System, such as geographic and economic displacement, forced migration, destruction of infrastructure, increased economic inequality, nutritional sustenance, fertility, mortality, conflicts, and spread of diseases or other human health consequences [135,Human System, such as geographic and economic displacement, forced migration, destruction of infrastructure, increased economic inequality, nutritional sustenance, fertility, mortality, conflicts, and spread of diseases or other human health consequences [135,human health consequences [135,136].