Sentences with phrase «as monoclonal»

A fact sheet that provides an overview of how the immune system functions and describes the actions of biological therapies, such as monoclonal antibodies, cytokines, therapeutic vaccines, the bacterium bacillus Calmet - Guérin, cancer - killing viruses, gene therapy, and adoptive T - cell transfer.

These are more specific therapies such as monoclonal antibodies and cancer vaccines, which target specific tumor antigens.

Extracellular interactions are excellent therapeutic targets because they are directly accessible to systematically delivered drugs such as monoclonal antibodies.

This has spurred hopes that biomedical countermeasures, such as monoclonal antibodies and vaccines, can help save lives and slow spread.

The company tested that potential therapy, a type of protein known as a monoclonal antibody, on mice with their own form of FOP and lo and behold, they stopped growing unwelcome new bone.

A study that used stored blood samples from U.S. Air Force personnel who conducted aerial herbicide spray missions of Agent Orange during the Vietnam war found a more than 2-fold increased risk of the precursor to multiple myeloma known as monoclonal gammopathy of undetermined significance (MGUS), according to an article published online by JAMA Oncology.

To target liposomes to certain tissues or cells, such as tumour cells, a specific binder of a unique protein (an antigen) on the targeted cell, known as a monoclonal antibody, must be linked to the liposome surface.

Not exact matches

In late clinical - trial findings published Wednesday in the New England Journal of Medicine, the monoclonal antibodies known as solanezumab and bapineuzumab were shown ineffective at changing the downward cognitive trajectory of Alzheimer's patients.

Novartis currently employs over 1,200 people in Cambridge and plans to continue expanding albeit only in specific areas such as biologic drugs like monoclonal antibodies and RNA interference molecules.

Ixekizumab is a monoclonal antibody - a cloned antibody - which neutralises the inflammatory effects of an interleukin (IL) a protein in the skin which carries signals to cells - known as (IL)-17 A.

Schlom, who lived through a decade of negativity over monoclonal antibodies, sees much of the nay - saying as par for the course.

As a researcher, Hockfield was among the first scientists to apply molecular biology to neuroscience, using monoclonal antibodies to study the brain.

At one point, scientists thought that interferon was going to cure cancer, as were monoclonal antibodies, for that matter.

Patients with multiple myeloma (MM) appear to have better survival if they are found to have monoclonal gammopathy of undetermined significance (MGUS) first, the state that precedes MM and which is typically diagnosed as part of a medical workup for another reason, according to a study published online by JAMA Oncology.

Known as a checkpoint inhibitor, tremelimumab is an investigational monoclonal antibody that «cuts the brakes» of the immune system by targeting cytotoxic T - lymphocyte antigen 4 (CTLA - 4), a protein that can switch off a patient's immune response.

Ipilimumab, sold as Yervoy, is an immunotherapy drug consisting of a monoclonal antibody that targets a protein receptor, CTLA - 4.

Today in Circulation, the journal of the American Heart Association, Vanderbilt University researchers published findings that the drug — a monoclonal antibody known as SYN0012 — shows promise in keeping heart valve leaflets supple.

She helped lead a GSK project focused on designing a monoclonal antibody to link to the HER3 receptor on human cells as a treatment for cancer.

For example, the most advanced therapy — ZMappTM, a cocktail of three monoclonal antibodies — is specific for Ebola virus (formerly known as «Ebola Zaire»), but doesn't work against two related ebolaviruses (Sudan virus and Bundibugyo virus) that have also caused major outbreaks.

Monoclonal antibodies, which bind to and neutralize specific pathogens and toxins, have emerged as one of the most promising treatments for Ebola patients.

Checkpoint inhibitors are monoclonal antibodies that target certain proteins that downregulate the immune system, such as programmed cell death protein 1 (PD - 1), programmed death - ligand 1 (PD - L1) and cytotoxic T - lymphocyte antigen 4 (CTLA - 4).

Until now, he says, it took as long as three months to produce enough monoclonal antibodies to protect huge populations, because the immune system only pumps out small quantities in response to infections.

As many in the industry point out, monoclonal antibodies have become a hugely lucrative and important therapeutic class — but their development was just as fraught, with just as many hurdles, as RNAAs many in the industry point out, monoclonal antibodies have become a hugely lucrative and important therapeutic class — but their development was just as fraught, with just as many hurdles, as RNAas fraught, with just as many hurdles, as RNAas many hurdles, as RNAas RNAi.

According to Wilson, monoclonal antibodies from (deliberately infected) animals were routinely used in the first half of the 20th century to try to treat diphtheria (an upper - respiratory illness that killed roughly 15,000 people annually in the early 1920s until a vaccine was formulated against it in 1924) and tetanus (a potentially fatal infection also known as lockjaw, because one of the muscles it destroys is in the jaw).

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, called the new work a «significant advance,» noting in a statement that it «opens the way to producing [monoclonal antibodies] that potentially could be used diagnostically or therapeutically» for the flu as well as other infectious diseases such as hepatitis C and the human immunodeficiency virus (HIV), which can lead to full - blown AIDS.

The committee then applied these criteria to all existing NIH - funded studies and concluded that only current — as opposed to future — development of monoclonal antibody therapies passed the test.

This research has important implications for the use of DNA - encoded monoclonal antibody technology as a platform for delivering the next generation of immunotherapies for cancer and many human diseases.

Thus, this study has implications for analysis of human vaccine studies, as in addition to searching for defined lineages it is worthwhile to perform functional analysis of monoclonal antibodies that may have found new structural solutions to high affinity binding which can not be discerned from DNA sequence alone.

In this study, the anti-HIV immune responses in immunized llamas were studied via deep sequencing analysis using broadly neutralizing monoclonal HCAbs as a guides.

Five - micron sections cut at 50 - μm intervals were mounted on charged glass slides, deparaffinized in xylene, and stained for expression of F4 / 80 as described by Cecchini et al. (43) with an anti-F4 / 80 monoclonal antibody provided by E. Richard Stanley (Albert Einstein College of Medicine), or for expression of CD68 with the commercially available monoclonal antibody PG - M1 according to the manufacturer's instructions (Dako CytoMation, Carpinteria, California, USA).

However, closer scrutiny of these studies raises questions about the role of CD4 + T cells as the sole mediators of corneal graft rejection, as corneal allografts undergo immune rejection in 33 % of the mice and 64 % of the rats treated with anti-CD4 monoclonal antibody (12, 13) and in 45 % of the CD4 KO mice (14).

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

SEATTLE, WA and DURHAM, NC — The HIV Vaccine Trials Network (HVTN) and the HIV Prevention Trials Network (HPTN) today announced the initiation of HVTN 704 / HPTN 085, also known as Antibody Mediated Prevention (AMP) or the AMP Study, a Phase 2b clinical trial to evaluate the safety and efficacy of VRC01, a broadly neutralizing monoclonal antibody (bnAb).

Bogen B. Peripheral T cell tolerance as a tumor escape mechanism: deletion of CD4 + T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma.

Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors.

In our laboratory we had the idea of localizing on tumor cells, with specific monoclonal antibodies, molecules, such as Major Histocompatibility Complexe (MHC), loaded with viral peptides, which can activate the T lymphocytes to attack the target tumor cells.

Reacts with AIDS sera and human monoclonal antibodies as determined by ELISA and Western blot.

A few other successful monoclonal antibodies were approved as treatments shortly after Rituxan hit the market, but it would take still another technological leap before mAbs really came into their own.

It is in this final tank that the engineered cells are stimulated to secrete the protein product — the monoclonal antibody itself, a protein derived from the mammalian immune system that can bind to a very specific target in the body, such as a tumor cell.

Not a light read, this tome is bursting with information about monoclonal antibodies, from the history of how these therapies were first developed to new approaches such as conjugate therapy, which combines antibodies with small - molecule drugs.

To make a monoclonal antibody — a class of biologic drug that, while perhaps not as well known as the influenza vaccine or insulin (two other kinds of biologics), is highly prevalent — scientists start by inserting a gene into a cell that will enable it to produce a desired protein.

To further validate our inclusion / exclusion co-localization analysis we then stained rat brain sections with MAOB - 2, a monoclonal antibody directed to residues 1 — 4 of Aβ, and which has been reported as absent of cross-reactivity with APP or CTFs [39].

Since that post, there have been exciting developments in the progress of the two most advanced of these immunotherapies: PD01A, the AS - targeting active vaccine from Austrian biotechnology startup AFFiRiS AG, developed using its patented «AFFITOME» neo-antigen discovery platform of molecular mimicry; and PRX002, a humanized monoclonal Ab (mAb) under development from Prothena Corp PLC, the successor of aggregate - clearing immunotherapy pioneer Élan Pharmaceuticals.

Intense intraneuronal Aβ immunoreactivity is observed in McGill transgenic rats throughout the neocortex (a-c, g - i, o), hippocampus (a-f, n) and amygdala (j - l), as detected with the anti-Aβ McSA1 monoclonal antibody.

For the detection of specific antigens, the following primary antibodies were used: mouse monoclonal anti-Tuj1 (Covance, Princeton, NJ, USA) as a neuronal marker, rabbit anti-L1 (kindly provided from Dr. Asou)[52] and rat monoclonal anti-L1 (Millipore, Billerica, MA, USA) as granule cell markers, rabbit anti-calbindin D28K (Millipore) as a Purkinje cell marker, and rabbit anti-glial fibrillary acidic protein (GFAP, DAKO, Denmark) as an astrocyte marker.

The primary antibodies were used at a dilution of 1:1,000 unless otherwise stated and their sources and molecular weights were as follows: Cell Signaling Technology (Danvers, MA, USA): β - actin, monoclonal HRP conjugate, 45 kDa; CREB, monoclonal, 43 kDa.

The monoclonal biotinylated W0 - 2 (EMI Millipore, USA) recognizing the Aβ N - terminus was used as detection antibody, and the reaction was developed by streptavidin - horseradish peroxidase conjugate and the chromogenic substrate 1 - Step Ultra-TMB (Pierce, USA).

Antisera against IgG (H+L) or against the F (ab») 2 fragments of IgG will also bridge PAP to IgM primary antibodies (such as IgM monoclonal antibodies) by virtue of common light - chain recognition.

Notably, the resultant amyloidomas were rapidly resolved, as compared to controls, when animals received injections of an anti-light-chain monoclonal antibody having specificity for an amyloid - related epitope.

Cancer immunotherapies also are known as biologic therapy, biotherapy, or biological response modifier therapy, and include cancer vaccines, monoclonal antibodies, and T cell transfer.