Sentences with phrase «as oligodendrocytes»

There are multiple forms of MS and those afflicted with it can experience a range of symptoms but the underlying problem is damage to the insulation around the nerves, known as myelin, and the cells that produce it, known as oligodendrocytes.

RIPK1, the researchers found, inflicts damage by directly attacking the body's myelin production plants — nerve cells known as oligodendrocytes, which secrete the soft substance, rich in fat and protein that wraps around axons to support their function and shield them from damage.

Not exact matches

If oligodendrocytes are making myelin in an environment with a lot of inflammation, as seen in MS patients, then the ER must work extra hard to make proteins to rebuild myelin and respond to surrounding inflammation.

A third class of glia, known as Schwann cells and oligodendrocytes, form insulating sleeves around neurons to keep their electric signals from diffusing.

Popko and his colleagues have previously shown that oligodendrocytes, the brain cells which produce myelin, possess an innate mechanism that responds to stressors such as inflammation.

To test the suitability of guanabenz as a potential treatment for MS, Popko and his team exposed cultured oligodendrocyte cells to interferon gamma — a molecule that increases inflammation — resulting in greatly increased myelin loss and cell death.

PDGFRα is a cell surface tyrosine kinase receptor involved in organ development and tumor progression, it is present in multiple cell types such as mesenchymal cells, neurons, astrocytes, megakaryocytes and oligodendrocyte progenitor.

Oligodendrocytes, a type of brain cell that plays a crucial role in diseases such as multiple sclerosis, are more diverse than have previously been thought, according to a new study led by Sten Linnarsson, Karolinska Institutet / SciLifeLab and Gonçalo Castelo - Branco, Karolinska Institutet.

In the November issue of Nature Methods, a team led by Paul Tesar, PhD, a NYSCF — Robertson Investigator at Case Western Reserve University, published a novel method in producing oligodendrocyte cells, the cells that are damaged in myelin - related disorders such as multiple sclerosis.

AST - OPC1, an oligodendrocyte progenitor cell population derived from human embryonic stem cells, has been shown in preclinical testing in animals and in vitro to have three potentially reparative functions that address the complex pathologies observed in demyelination disorders, such as spinal cord injuries, and multiple neurodegenerative diseases, including multiple sclerosis and white matter stroke.

My laboratory studies the molecular mechanisms underlying the enhanced vulnerability of oligodendrocytes in neurodegenerative diseases such as Alzheimer's, including the age - related impairment of oligodendrocyte regeneration from glial progenitors.

Extensive damage to white matter (myelin - rich brain areas) characterizes Alzheimer's disease, Huntington's disease, and Parkinson's disease, pointing to myelin damage and oligodendrocyte impairment as a common path to the progression of these diseases, even though each of these diseases may have a different cause.

Human NSCs have been generally considered to have limited differentiation with the capacity to differentiate into only neurons, astrocytes, and oligodendrocytes under permissive conditions, as we have observed (Figure 1B — D).