Sentences with phrase «as oligomeric»

However, fibrillar Aß preparations lead to similar decrease in MMP as oligomeric Aß, suggesting that mitochondrial dysfunction is mediated by both species in contrast to defects in long - term potentiation (LTP) where only oligomeric Aß inhibits LTP [59].

They found that adding one particular set of these compounds, known as oligomeric procyanidins (PCs), to the food made the biggest difference in keeping the mice's weight down if they were on high - fat diets.

Not exact matches

Furthermore, in brains from APP transgenic mice conformation - specific antibodies have revealed the early appearance of intraneuronal fibrillar and oligomeric Aβ immunoreactivity, which declined as amyloid plaques appeared, and further became evident in the extracellular space [10].

Examination of brain homogenates from immunized TG mice revealed no effect on monomeric human AS as compared with vehicle - treated animals, but a 45 % reduction in oligomeric AS and a trend toward reduction of human AS dimerAS as compared with vehicle - treated animals, but a 45 % reduction in oligomeric AS and a trend toward reduction of human AS dimeras compared with vehicle - treated animals, but a 45 % reduction in oligomeric AS and a trend toward reduction of human AS dimerAS and a trend toward reduction of human AS dimerAS dimers.

Those inducedAbs would epitope map to recognize the C - terminus of AS as well as full - length and N - terminal truncated AS species, and also bind to oligomeric AS aggregateAS as well as full - length and N - terminal truncated AS species, and also bind to oligomeric AS aggregateas well as full - length and N - terminal truncated AS species, and also bind to oligomeric AS aggregateas full - length and N - terminal truncated AS species, and also bind to oligomeric AS aggregateAS species, and also bind to oligomeric AS aggregateAS aggregates.

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

From our point, ROS scavengers as well as mitoprotective strategies might be one part of a complex treatment strategy for AD also comprising drugs lowering the early oligomeric Aß species which all need to be applied decades before the disease is diagnosed.

Another benefit of these vegetables is that they contain indole -3-carbinole (I3C), the biological effects of which are attributed to its oligomeric products, such as 3,3» - diindolylmethane (DIM).