This devastating form of dementia is characterized by the accumulation of beta - protein clusters in the brain known
as oligomers.
Consistent with this, AFF 1 immunotherapy reduced the accumulation of AS neuropathology in neuronal bodies and neuropil at the cardinal sites for this LBD model (neocortex and hippocampus), and reduced the levels of AS dimers as well
as oligomers in brain homogenates, while having no significant effect on monomeric AS.
Summary: Many of the steps are known in using glyoxal with hydrogen peroxide to form dicarboxylic acids and chains of hydrocarbons, known
as oligomers.
While these compounds did not reduce the amount of protein aggregates, they were found to reduce the protein's toxicity and to increase the stability of amyloid fibrils — a finding that lends further evidence to the theory that smaller assemblies of amyloid - beta known
as oligomers, and not the fibrils themselves, are the toxic agents responsible for Alzheimer's symptoms.
A purified yeast Sec61 complex bound to monomeric yeast ribosomes
as an oligomer in a saturable fashion.
Not exact matches
And that sequence can form long chains called
oligomers as well
as fibers called fibrils.
These
oligomers are also the starting materials for troubling atmospheric aerosols, known
as secondary organic aerosols.
Amyloid - β 42 (Aβ42) has a strong ability to oligomerize to form diffusible
oligomers as well
as larger polymers called fibrils that form insoluble amyloid plaques, a major hallmark of AD.
Last but not least, EP1LOGUE features a proprietary vasodilating and nitric oxide - boosting formulation of gallate - enhanced
oligomers derived from grape seeds and marketed
as 10x more powerful than the classic citrulline.