Lethality was attributed to diverse cellular and developmental defects, such
as organ formation and patterning defects.
Not exact matches
The finding, reported by researchers at Harvard T.H. Chan School of Public Health, Northeastern University, and MIT, provides insights into
organ formation in an embryo, healing of a wound, and even invasion of cells into surrounding tissue,
as occurs in cancer.
In his case, the problem had progressed to a condition known
as nonalcoholic steatohepatitis (NASH), which is characterized by liver inflammation and
formation of scar tissue in the
organ.
The authors note that the
formation of each different
organ bud type may require some fine tuning to optimize tissue self - organization, and further addition of neural cell types may be necessary, but this research may soon provide exciting model systems for the study of basic biology and pathology
as well
as providing appropriate replacement tissues for the treatment of many patients with no other viable options.
«The results suggest that such «master» regulatory factors could activate regions of the genome that are normally inactive, leading to the
formation of
organs during development, or the initiation of pathological changes in cells that lead to diseases such
as cancer,» Taipale said.
Ciliopathies can manifest
as severe syndromic diseases that affect lung and kidney function, central nervous system development, bone
formation, visceral
organ organization, and reproduction.
This connective tissue is made up of collagen proteins, and is essential in the
formation of such specialized tissues
as bone and cartilage,
as well
as provides the connective support for the various
organs and systems in the body.
Hemangiosarcoma is insidious,
as it attempts to build it's own blood vessel network, making blood blister like
formations which disrupts normal
organ function.