Sentences with phrase «as organoids»

Crohn's Disease Program grantee Hans Clevers of the Hubrecht Institute is leading research investigating how lab - grown miniature versions of organs, known as organoids, might help patients.

ANN ARBOR, Mich — By combining engineered polymeric materials known as hydrogels with complex intestinal tissue known as organoids — made from human pluripotent stem cells — researchers have taken an important step toward creating a new technology for controlling the growth of these organoids and using them for treating wounds in the gut that can be caused by disorders such as inflammatory bowel disease (IBD).

But, he says, mini-brains are «by far the most complex structures that have been grown as organoids.»

Where possible, we replace our animal experiments with in vitro models, such as organoids, reducing the number of laboratory animals.

Single - cell technologies will be applied to experimental model systems such as organoids, miniature organs grown in the petri dish from one or more cells.

Consisting of optimized media and reagents, MimEX ™ Tissue Model Systems provides an alternative to current 3 - D cell culture modes, such as organoids, with the added benefit of...

(That's not always the case, as the organoid work on Alzheimer's suggests.)

Not exact matches

Since the first human brain organoids were created from stem cells in 2013, scientists have gotten them to form structures like those in the brains of fetuses, to sprout dozens of different kinds of brain cells, and to develop abnormalities like those causing neurological diseases such as Timothy syndrome.

Scientists say that these «gastric organoids» could also be used to understand diseases such as cancer, and to test the stomach's response to drugs.

Within 24 hours, the team found that H. pylori was causing the organoid cells to divide twice as fast as normal, and activating a particular gene, c - Met, that can cause tumours.

These «organoids» can develop as many as six layers of cerebral cortex — the outer surface of the brain.

When these cultured cells were exposed to an air / liquid interface in the laboratory, they stratified, generating what the authors referred to as a multi-layered, «skin - like organoid.»

Even though DENV2 infected the cells such as ZIKV, there were no damaging outcomes registered to the neural cells, neurospheres or organoids.

These so - called endometrial organoids promise to shed light onto the processes that occur during the monthly menstrual cycle and open up the possibility of studying diseases of the uterus, such as endometrial atrophy (thinning of the lining) or cancer, in a lab culture system.

Scientists headed by Dr. Stevens Rehen differentiated human induced pluripotent stem (iPS) cells into neural stem cells and into further complex tridimensional structures, known as neurospheres and brain organoids.

That is necessary if the organoids are to grow bigger, probably the only way they can mimic fully grown brains and show how disorders such as autism, epilepsy, and schizophrenia unfold.

Importantly, the technique will also make it possible for researchers to grow organoids from diseased endometrium such as in endometrial atrophy or cancer.

These organoids, as they are known, could provide new insights into the early stages of pregnancy and conditions such as endometriosis, a painful condition that affects as many as two million women in the UK.

Neurospheres and brain organoids represent excellent models to investigate developmental neuropathologies, as they can outline, in vitro, several characteristics of the fetal brain formation.

They also demonstrated that the organoids respond to female sex hormones and early pregnancy signals, secreting what are collectively known as «uterine milk» proteins that nourish the embryo during the first months of pregnancy.

The organoids with the mutated gene grew to the same proportions as the first group, but they developed few folds and the ones they did develop were very different in shape from normal wrinkles.

Prof. Reiner says, «We discovered a significant difference in the physical properties of cells in the two organoids, but we observed difference in their biological properties as well.

The new «tumor in a dish» method begins by taking the cancerous tissue removed during surgery or biopsy, cutting it up into small pieces and putting them in a special collagen gel that maintains them as «organoids» that retain the three - dimensional structure of the original tumor and include supporting cells from the tumor's environment.

Fine got federal approval this year to try such a drug screen on one patient whom he describes as «well - connected,» creating an organoid from her cells and adding bits of her tumor to it in hopes of throwing drug after drug at it until one vanquished the organoid's cancer.

And by creating personalized organoids from the reprogrammed cells of patients, scientists could study disease in a very individualized way — or maybe even use organoid structures to replace certain damaged tissues, such as in the liver or spinal cord.

Moving forward, he was able to place these taste stem cells in a culture dish and prompt them to grow into the different mature taste cell types, thus creating a taste bud in a dish — scientifically known as taste organoids.

From here on, the organoids are halved every two weeks or so, routinely surviving as long as 150 days.

Because those organoids include stroma, a scaffold of connective tissue essential for tumor growth, they may prove better for studying therapies that target the stroma, such as cancer immunotherapy.

Lütolf's lab found that this attachment itself is immensely important for growing organoids, as it triggers a whole host of signals to the stem cell that tell it to grow and build an intestine - like structure.

As such, it provides a means of moving organoids from basic research to actual pharmaceutical and clinical applications in the future.

Kuo's organoids contain a mix of cell types, which enables «observation of higher - order behaviors such as muscle contraction,» he says.

And as Clevers's lab has shown, organoids can help predict how an individual will respond to a drug — making personalized medicine a reality.

But Sawyers discovered that he could easily grow organoids from normal prostate tissue — «it just works beautifully,» he says — and then use gene - editing techniques such as CRISPR to study any cancer mutation he wants.

His lab is continuing to use the zebrafish as a model organism, but Junker also sees great potential in applying the technique to human organoids.

A new technique — called DNA Programmed Assembly of Cells — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hours.

The new technique — called DNA Programmed Assembly of Cells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hours.

The authors used the engineered hydrogels to create a 3D growth environment — known as a matrix — which provides optimal physical and biochemical support for organoid growth.

These DNA strands act both as a sort of molecular Velcro and as a bar code that specifies where each cell belongs within the organoid.

To demonstrate the precision of the technique and its ability to generalize to many different human tissue types, the research team created several proof - of - principle organoid arrays mimicking human tissues such as branching vasculature and mammary glands.

Importantly, the organoids developed genetic changes that occurred over time, a phenomenon known as clonal evolution.

Because organoids can be generated with high efficiency and speed from patient samples, they can serve as a personal cancer model that can guide clinical decision - making.

These organoids form all of the cell types present in human intestine, but they grow as cysts surrounded by thick extracellular matrix gels with their «apical» cell surface (which is normally exposed to the content of the gut) facing an enclosed lumen.

Our brain development atlas will serve as a much - needed framework to calibrate these organoids against the real human brain.»

«Because the primary Small Intestine Chip recapitulates the physical microenvironment that cells experience inside the human body, such as fluid flow and cyclic peristalsis - like stretching motions, it exhibits a genome - wide gene expression profile that comes closer to its in vivo counterpart than that of the same intestinal cells grown as 3D organoids,» said first - author Magdalena Kasendra, Ph.D., a former Postdoctoral Fellow on Ingber's team and now Principal Scientist at Emulate, Inc. in Boston.

His scientific work focuses on combining organoids, bioengineering, and animal studies to regenerate damaged bile ducts in the liver as an alternative therapy to liver transplantation.

Targeting the labeled cells for analysis, they revealed that their organoids contained a population of sensory cells that have the same functional signature as cells that detect gravity and motion in the human inner ear.

Clevers and other scientists have developed organoids of the gut, liver, lung, brain, and many other human organs that can be used to model disease or to serve as test beds for drugs.

AMSBIO has introduced two new products to assist the increasing number of scientists adopting organoid culture as a physiologically relevant model for organ development

Through the use of stem cell - based organoids researchers are making big strides in the study of neurodevelopmental diseases such as schizophrenia and autism.

AMSBIO announces the availability of two new formulations of Basement Membrane Extract (BME) known as Cultrex BME 2 (organoid growth matrix) and Cultrex BME 3 (xenograft / tumorgraft matrix).