Sentences with phrase «as oxidant stress»
In depth biochemical investigations coupled with electron microscopy have shown that at this threshold the balance between safety and toxicity of copper becomes very unstable and liver damage, involving a process known as oxidant stress, becomes very likely.
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Jason M. Morrow, M.D. Vanderbilt University School of Medicine Isoprostanes as markers and mediators of oxidant stress in humans
Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96
A relative increase of oxidants over antioxidants, known as oxidative stress, is an important factor in many diseases, which includes asthma.
Oxidant stress is why we get wrinkles; and why we lose some of our memory, and why our organ systems break down as we get older.
HSF4 belongs to a family of heat shock transcription factors that regulate the expression of heat shock proteins in response to different stresses, such as oxidants, heavy metals, elevated temperatures and bacterial and viral infections [96].