Sentences with phrase «as phage»

In the 1950s, a new, highly virulent strain of S. aureus, known as phage type 80/81, spread worldwide, causing sepsis, skin lesions, and pneumonia.

D'Herelle's treatment came to be known as phage therapy.

The antibiotic, Epimerox, targets weaknesses in bacteria that have long been exploited by viruses that attack them, known as phage, and has even been shown to protect animals from fatal infection by Bacillus anthracis, the bacteria that causes anthrax.

Patients in danger of dying from uncontrollable bacterial infections could find new allies: killer viruses known as phages.

Here, hordes of viruses known as phages assault a bacterium to turn it into a virus - making factory.

Bacteriophages, also known simply as phages, came to light around 90 years ago, when two European scientists independently

A new technique allows researchers to examine pieces of often - overlooked DNA outside bacterial chromosomes, including viruses known as phages (as shown above), which may play a role in disease.

Extrachromosomal DNA can include bacteria - infecting viruses, known as phages, and strands of self - replicating DNA, known as plasmids, often picked up from other bacteria.

Also presented are possible alternative approaches to tackling infections, such as phages (viruses that kill bacteria) sourcing new antibiotic leads from oceans, soils and host - associated microbiomes in humans, komodo dragons and leafcutter ants.

Not exact matches

As a result, phage therapy is now used only for the sickest patients, as a treatment of last resorAs a result, phage therapy is now used only for the sickest patients, as a treatment of last resoras a treatment of last resort.

In contrast, phages «exist everywhere,» making them potentially more broadly useful as bacteria hunters, Nugen said.

The researchers embedded phages into soluble «sugar glasses» or films made with pullulan, a polysaccharide used to prolong the shelf life of fruits and eggs; trehalose, a sugar used as stabilizing agent in freeze drying; or a combination of two substances.

This is good news, because phage could be used as alternative treatment when antibiotics become resistant to pathogenic bacteria.

«Phage have been used as an alternative to antibiotics for decades in eastern European countries, particularly for treatment of urinary tract infections,» said corresponding author Catherine Putonti, PhD, Associate Professor of Bioinformatics, Loyola University, Chicago.

Bacteriophages, also known as «phages,» are viruses that infect and kill bacteria.

In the study, the phage, called «CR5,» showed high antimicrobial activity against the bacterium, Cronobacter sakazakii, as well as against several other species of Cronobacter, which can also cause dangerous illness, said coauthor Sangryeol Ryu, professor in the Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Korea.

«This is going to be one of those transformative papers,» says microbiologist Martha Clokie, who studies viruses that infect bacteria (known as bacteriophages, or phages) at the University of Leicester, UK.

Next, the researchers inoculated kitchen utensils, such as wooden and plastic cutting boards, knives and surgical gloves, with the bacteria and phages, after which the number of bacteria and phages in the utensils was monitored for two hours.

In this case as well, the phages effectively inhibited bacterial growth.

Research focused on the utilisation of viruses that infect and kill bacteria, known as bacteriophages or phages, in preventing infectious diseases has gained new traction after bacterial resistance to antibiotics has become a global problem.

Phages would require a less traditional approach to get official approval, such as the annual process for influenza vaccines in which manufacturers secure approval of new formulas based on the flu bug that is going around that year, instead of conducting big clinical trials every time.

However, the scientists note, for items with a more neutral pH, such as melon and cucumber slices, phage disinfection outperforms such commercially important sanitizers as chlorine.

As other viruses do, phages enter susceptible cells and insert their own genes.

For instance, phage disinfection does nt work well on acidic foods, such as apples or, presumably, tomatoes.

Indeed, the lack of any flavor in phage mists might even give them an advantage over alternatives — such as vinegar mists or chlorine baths — for sanitizing salad greens.

That company has been gaining renown for pioneering exploitation of phages to quash a host of food poisoning agents in other venues, such as meats (SN: 6/3/00, p. 358).

Thats good, Leverentz adds, since you wouldnt want any of the phages delivered in the kitchen to also wipe out beneficial microbes, such as some lactobacilli.

John suggested to Fred that he use the phage as the training wheels for learning how to sequence DNA.

That's because gut phage from mice treated with one drug carried high levels of genes that confer resistance to different drugs, which means that the phage could serve as backup when bacteria must find ways to withstand a variety of antibiotics.

Timed with the hundredth anniversary of their discovery, a new review published in the British Journal of Pharmacology examines the challenges and opportunities of developing phages as health - promoting, commercially - viable biopharmaceuticals.

Bellen and Venken attached artificial docking sites to phages — a virus that targets bacteria — which they introduced in both the bacteria and in the fruit fly genomes to act as sticky points for the DNA segment being implanted in the latter's genome.

Phages were used for more than 75 years as therapy in Eastern Europe, but they fell out of favour in the western world when antibiotics were discovered.

«One of the challenges lies in the fact that more than 90 % of phage populations are as yet unidentified, and therefore considered to be the «dark matter» of the biological world,» said Dr. Hill.

«We tend to think of phages as nature's «nano - machines», self - assembling complex biological survival machines capable of replicating faster than any other biological agent,» said Dr. Hill.

She explained that phages outnumber their bacterial prey by a factor of 10 to 1, and that they have been proposed as the agents of change in recipients of faecal microbiota transplantations used to treat resistant or recurring bowel disease.

Engineered phage viruses show promise as targeted assassins - genetic manipulation might make it easier for them to gain regulatory approval

Thomas G. Bernhardt of Texas A&M University and his colleagues found the protein in a tiny virus, or phage, known as Q Beta.

«As bacteria's natural enemies, their potential as sources for ways to kill bacteria should have been thoroughly explored long ago, but it is only now, with the emerging worldwide crisis in antibiotic resistance, that phages are finally getting attention in their own right,» Ing - Nang Wang, another co-author on the report, remarkAs bacteria's natural enemies, their potential as sources for ways to kill bacteria should have been thoroughly explored long ago, but it is only now, with the emerging worldwide crisis in antibiotic resistance, that phages are finally getting attention in their own right,» Ing - Nang Wang, another co-author on the report, remarkas sources for ways to kill bacteria should have been thoroughly explored long ago, but it is only now, with the emerging worldwide crisis in antibiotic resistance, that phages are finally getting attention in their own right,» Ing - Nang Wang, another co-author on the report, remarks.

Phil Ross: There was a novel way back, written by Sinclair Lewis, I think Arrowsmith, where — this is in the 1920s before antibiotics were invented — where his scientist hero tries to use phages to... as a way of killing up bacteria to save people's lives, and that was an actual research project, which has come back now that bacteria are in many cases immune to antibiotics.

Nevertheless, in this research two limitations were observed in the use of orally administered bacteriophages: the reduced stability of the phages in extremely acid environments, such as the stomach, and short residence time in the intestinal tract.

Incorporating a synthetic phage genome into Gram - positive bacteria has so far been very problematic, as their cell walls are so thick.

For example, specially targeted phages have been suggested as a possible therapy for conditions like cystic fibrosis, which is caused by frequent bacterial lung infections.

«So far, no one has looked across a variety of strains of bacteria, as we have done with Staphylococcus aureus, to find these extrachromosomal phages that have potential to play an important role in disease,» says Bryan Utter a postdoc in the lab and the first author of the research published June 25 in PLoS ONE.

These phages and plasmids can easily move between bacterial cells, and scientists have known for some time that, as a result, these so - called mobile genetic elements can play important roles in virulence and antibiotic resistance.

In a study published today in the journal Nature, the researchers refer to this alternative model as «piggyback - the - winner,» and it could have implications for phage - based medicine and ecosystem resilience in the face of environmental disturbances that promote microbial blooms.

These CRISPR sequences act as a form of genomic memory that can be accessed to defend the cell when it is invaded by plasmids or phages that contain the recorded sequences.

In 2007, Rodolphe Barrangou, a former Chairman of the Board of Directors of Caribou Biosciences and current scientific advisor, led the group that characterized CRISPR systems as a form of prokaryotic adaptive immunity that provides a critical line of defense against invading phages, plasmids, and environmental nucleic acids.

The success of this study may provide the foundation for an improved program for high school students to foster their interest in research and gain invaluable experiences outside of the classroom while providing bacteriophages that can serve as the base chassis of synthetically engineered phages for diagnosis and treatment of MDR pathogens.

There is considerable interest in using phages as diagnostics and therapeutics of multi-drug resistant (MDR) bacteria.

With the use of careful phage isolation procedures and environmental samples from various locations, such as alternative media usage and modified plaque - picking methods, we isolated potentially novel phages.