Sentences with phrase «as phosphatases»

A mutation in one of the genes that controls this pathway, PTEN (also known as phosphatase and tensin homolog), can cause a particular form of autism called macrocephaly / autism syndrome.

The protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop.

CHICAGO — The protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop.

Not exact matches

In particular, protein tyrosine phosphatase, receptor type, F (PTPRF) may serve as a biomarker linking insulin resistance with insufficient milk supply.

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

When these building blocks interact with a cervical cancer biomarker known as glycosylphosphatidylinositol - anchored placental alkaline phosphatase, or GPI - anchored PLAP, which is located on lipid rafts, they self - assemble into nano - scale chains, or «nanofibrils», that glue lipid rafts into large clusters.

Recent studies such as ours, however, establish protein phosphatases as positive and essential regulators of signal transduction, with remarkable substrate specificity and coordinated activities.

These phosphate groups are attached to proteins by enzymes known as kinases, while phosphatases act as their counterparts by removing them.

When postdoctoral researcher and first author, Karen M. Doody, Ph.D., screened samples from rheumatoid arthritis patients for the expression of phosphatases, she discovered that an enzyme known as RPTPσ, short for receptor protein tyrosine phosphatase sigma, is highly expressed on the surface of FLS.

Furthermore, their study reveals novel physical as well as functional links to phosphatase - based regulation of human cancer.

They show that it is a substrate for calcineurin, the phosphatase target of the immunosuppressive drugs cyclosporin A and FK506, and that it exists in activated cells as a complex with the transcription factor AP - 1 (Fos - Jun).

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways.

Phosphatase and tensin homolog (PTEN): Adding an extra copy of the tumor suppressor gene PTEN to mice produces lower rates of cancer, much as expected, but also increased life span.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

Navire Pharma is a new company aimed at developing novel small - molecule inhibitors of a tyrosine - protein phosphatase called SHP2 (also known as PTPN11) for genetically - driven and treatment - resistant cancer.

Title: A genome - wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation (IN PRESS, Oct 2012) Authors: Sharrocks A, Yang S - H, Kalkan T, Haslam C, Smith A Date: IN PRESS, Oct 2012 Publication Details: PLoS Genetics

Igaki identified the ligand Sas and the receptor - type tyrosine phosphatase PTP10D as the cell - surface ligand - receptor system that drives tumor - suppressive cell competition.

It is estimated that there are 2000 or so protein kinases and perhaps as many as 1000 phosphatases (Hunter, 1995).

Through a genetic screen in Drosophila, Igaki identified the ligand Sas and the receptor - type tyrosine phosphatase PTP10D as the cell - surface ligand - receptor system that drives tumor - suppressive cell competition.

It's interesting that Fox01 is normally present in the nucleus, and it binds to important gene sequences, and activates important genes; genes such as glucose 6 phosphatase and PEPCK (Phosphoenolpyruvate Carboxykinase).

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.

Individual cells positive for alkaline phosphatase (AP), a marker for pluripotent cells, appear as early as 4 days after infection (Fig. 1A, inset).

Journal coverage includes basic signaling interests (e.g. neurotransmitters, ions and ion channels, receptors and messenger molecules, and kinases / phosphatases), as well as electrical signaling, signaling in neural circuits, neuroimaging, signaling aspects of pathologies, synaptic transmission and plasticity, and therapeutic intervention.

PTPN22 is involved in the formation of a key protein known as lymphoid tyrosine phosphatase (LYP), which helps control the activity of T and B cells in the immune system.

In vitro, Pds has been shown to produce β - glucosidase, N - acetyl - β - glucosaminidase, acid and alkaline phosphatases, esterase / esterase lipase / lipase, leucine and vailine arylamidase, naphthol - AS - B1 - phophohydrolase, various proteinases (albumin / casein / gelatin), and urease, while no enzymatic activity was indicated for cystine arylamidase, α - chymotrypsin, alpha / beta galactosidase, trypsin, β - glucoronidase, α - fucosidase, and α - mannosidase [11].

Following three washes in PBS - T, plates were incubated with pooled sera from malaria - exposed Malawian adults or malaria - naïve UK individuals at a 1:1,000 dilution in PBS - T, 2 % BSA followed by an alkaline phosphatase - conjugated anti-human IgG secondary antibody (Sigma) and detected as above.

Polycistronic cassettes that contained the KLF4L isoform had more robust initiation of reprogramming (evaluated by an alkaline phosphatase - positive assay) as well as stabilization (Nanog - GFP reporter activation and silencing of factor - linked mCherry).

Zinc deficiency can show up on a liver function blood test as low alkaline phosphatase levels.

These enzymes are necessary to absorb and digest the nutrients in the milk such as lactase to digest lactose and phosphatase to absorb the calcium and other minerals.

In addition, altered enzymatic activities, such as an increased phosphatase activity and / or seryl phosphorylation of the insulin receptor substrate by glycogen synthase kinase - 3 (GSK - 3), have also been shown to be involved in some cases of type 2 diabetes (19,20).

Creating a more alkaline environment in the body may help with the detoxification process as well as help alkaline phosphatase function better.

Test subjects» body weights, as well as hemoglobin, packed cell volume, serum alkaline phosphatase and serum albumin are measured.

One should also consider hepatic lipidosis when the cat's blood alkaline phosphatase level is significantly above normal as well, particularly in cats that refuse to eat.

Often there are laboratory changes in the blood tests consistent with hyperadrenocorticism such as an increase in liver tests such as the alkaline phosphatase, alanine transaminase (used to be the SGPT) and cholesterol.

Solter PF, Hoffmann WE, Hungerford LL, Peterson ME, Dorner JL: Assessment of corticosteroid - induced alkaline phosphatase isoenzyme as a screening test for hyperadrenocorticism in dogs.

Other standout lots were the very strong «Self Portait as a Heel - Part Two,» by Jean - Michel Basquiat (1960 - 1988), Lot 16, shown at the top of this article, an acyrilic and oil paintstick on canvas, 1982, that sold for $ 772,500, well above its high estimate of $ 600,000; two sculptures by Agnes Martin (b. 1912), Lots 17 and 18, which sold for $ 217,000 and $ 233,500, respectively, both considerably over their respective high estimates of $ 45,000 and $ 120,000; «Broadway and 64th Street,» a very good, large oil by Richard Estes (b. 1932), that sold above its $ 300,000 high estimate for $ 354,500; Lot 31, a large canvas from his Rorschach series by Andy Warhol (1928 - 1987) that more than doubled its high estimate and sold for $ 684,500; Lot 13, «Alkaline Phosphatase - Polyethelene Glycol,» by Damien Hirst (b. 1965), 1992, sold for $ 140,000 and had a high estimate of $ 80,000; and Lot 37, «a delightful large acrylic on vinyl tarpaulin by Keith Haring (1958 - 1990) that sold for $ 200,500 and had a high estimate of $ 150,000.