Sentences with phrase «as pyruvate»

The Basenji, West Highland White terrier, English springer spaniel, Alaskan malamute, poodle and beagle breeds can be congenitally predisposed to this condition due to defects in enzymes (such as pyruvate kinase) or in the red blood cells.

Not exact matches

Ideally, ethyl pyruvate would be cheaper than DEET and sprayed on bed nets or other surfaces to act as a short - term human invisibility cloak to keep mosquitoes away, Ray says.

One such chemical, ethyl pyruvate, is a fruity - scented cpA inhibitor that is already approved as a flavor agent in food and can be found in some wines.

The former is ideal for soft - tissue contrast, and the latter has extremely fine imaging resolution due to a revolution in the technology called dynamic nuclear spin polarization, which is used to track minute biochemistry in the body — such as the transition of the naturally occurring chemical pyruvate to lactate.

They settled on two compounds: ethyl pyruvate, a fruity - smelling cpA inhibitor used as a flavor agent in food, and cyclopentanone, a minty - scented cpA activator used as a flavor and fragrance agent.

The «HIF - 1 signaling pathway» also inhibits Tricarboxylic acid cycle through the inhibition of circuits that trigger the effector protein PDHA1 with diverse GO annotations such as tricarboxylic acid cycle, acetyl - CoA biosynthetic process from pyruvate or carbohydrate metabolic process

This pathway allows glutamine to be converted into a variety of metabolic intermediates such as aspartate, asparagine, citrate and oxaloacetate and pyruvate [103].

In high carbohydrate diet - induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase / DLD in striated muscles, as well as that of selected glucose / pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (PubMed: 26671069).

Goat fetal fibroblasts were isolated as described previously [22] and cultured in DMEM supplemented with 15 % FBS, 1 % sodium pyruvate and 1 % penicillin streptomycin to achieve 80 — 90 % confluency on the day of transfection.

This process triggers the production of lactate and pyruvate, which contribute to increasing the muscles cells as a result of their osmotic activity.

In fact, it is the presence of 1,2 - dithiolane that allows alpha - lipoic acid to participate as a cofactor in the enzyme activities of pyruvate dehydrogenase and alpha - ketoglutarate dehydrogenase.

The latter is important to understand, as deamination (the process by which the amino group is removed) creates two products: Ammonia and a carbon skeleton (Acetyl CoA / acetoacetate or pyruvate).

Aβ is believed to penetrate neuronal plasma membranes, where it leads to lipid peroxidation.10 It has also been implicated in deactivating a subunit of the pyruvate dehydrogenase complex, thereby inhibiting conversion of pyruvate to acetyl CoA and the eventual production of cellular energy as ATP.32 Another way Aβ affects glucose metabolism in the brain is that fragments of Aβ disrupt insulin signaling by binding to neuronal synapses, which alters their shape and function.15, 38 Insulin receptors are abundant at synapses, so if the integrity of the synapse itself has been compromised, the receptors won't function effectively.

In some studies, subjects consuming relatively large doses of pyruvate have reported minor gastrointestinal disturbances such as diarrhea and flatulence.

Any potential adverse effect of gluconeogenesis would be determined from the initial substrate; whether one is using amino acids to manufacture glucose or other precursors that are extremely benign such as from ketones, the glycerol backbone of fats, or from lactate and pyruvate recycling.

Alpha - Lipoic acid (LA) is a disulfide compound that is produced in small quantities in cells, and functions naturally as a co-enzyme in the pyruvate dehydrogenase and alpha - ketoglutarate dehydrogenase mitochondrial enzyme complexes.

The traditional or modified ketogenic diets should not be used in individuals who have fatty acid oxidation defects, pyruvate carboxylase deficiency, primary carnitine deficiencies, organic acidurias, defects in ketone metabolism, disorders that require high dietary carbohydrates as part of their treatment, severe liver disease or hypoglycaemia under investigation (4).

His main field of work are disorders of brain energy metabolism such as GLUT1 deficiency syndrome or pyruvate dehydrogenase deficiency.

Alpha - lipoic acid, a coenzyme of pyruvate and alpha - ketoglutarate dehydrogenase, has been used in Germany as an antioxidant and approved treatment for diabetic polyneuropathy for 40 years.

Creatine pyruvate was found to be more effective than creatine citrate (19) which is promising since creatine citrate appears to be as effective as creatine monohydrate.

Progressive retinal atrophy (PRA) has been identified in the breed, as has Pyruvate kinase (PK) deficiency.

Pyruvate kinase deficiency has been identified in the breed, as has progressive retinal atrophy (PRA) and flat chested kitten syndrome.