Sentences with phrase «as resistance to therapy»

Not exact matches

They note that targeting inflammation to treat infections offers an advantage over antibiotic therapy, as the former hinders gene transfer and the evolution of pathogens, while the latter promotes bacterial evolution and, ultimately, antibiotic resistance.

Currently, many patients who acquire resistance to EGFR - targeted therapy undergo a tumor biopsy and are designated as either positive or negative for specific secondary mutations.

However, not everyone's melanoma will benefit equally from MAPK - targeted therapies, and initial benefits might wane over time as tumors develop resistance to treatment.

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

My cancer systems biology team at the University of California, Merced, is tackling diagnosis and treatment of therapy - resistant cancers by elucidating the network of changes within cells as a way to identify new drug targets and circumvent cancer resistance.

This discovery is an important step in the personalisation of the treatment of colorectal cancer, as the presence of this mutation is associated with an increased resistance compared to standard therapies.

Just as chemotherapy often requires several drugs to combat resistance in cancerous cells, successful antimicrobial therapy against some pathogens requires a combination of drugs.

Until RDTs became widespread, almost all fevers were treated as if they were malaria, leading to the overuse of the new generation of «wonder drugs,» artemisinin - based combination therapies (ACTs), which were in danger of being lost to drug resistance.

As a clinician - scientist with a translational research focus, Dr. Deininger is heading an extramurally funded research laboratory that is dedicated to the study of signaling pathways, drug resistance, and new molecular therapies in leukemia.

«Also, we believe that anti-CtBP therapies such as HIPP may be able to complement current therapies to counter drug resistance and decrease metastasis, ultimately increasing our ability to control and cure colon cancer.»

Combined with a relatively new quinoline such as piperaquine — to which resistance is still rare — the drug, or a chemical cousin, might form a cheap and safe new combination therapy, says Kelly.

And while new therapies have been effective in releasing the immune system's restraints to unleash the body's own cancer - fighting powers, they only work in about half of melanoma patients and often lose their potency as the cancer develops resistance.

«Current therapies take advantage of this by using targeted drugs such as Trastuzumab or Lapatinib to specifically inhibit ERBB2, but eventually they become ineffective as the cancer develops resistance to those drugs.»

«These stem cells possess the ability to self - renew and are thought to be associated with resistance to standard therapies as well as with metastasis.

Researchers developed the strategy as a way to develop inhibitors of «undruggable» proteins and overcome drug resistance, a common shortcoming of targeted therapies.

«We have previously demonstrated the role of MDSCs as important mediators of resistance to immune therapy approaches.

This complexity contributes to its aggressive nature and resistance to conventional therapies such as chemotherapy and radiation therapy,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at Massey Cancer Center, professor and chair of the Department of Human and Molecular Genetics at the VCU School of Medicine, and director of the VIMM.

In an effort to keep artemisinin resistance at bay, the World Health Organization (WHO) has recommended artemisinin combination therapies (ACTs)-- uniting artemisinin derivatives with bygone antimalarial drugs — as the preferred front - line treatment.

Increasing resistance to existing antiviral therapies and the short time - frame in which these agents are effective highlight the critical need for new treatments, such as Eritoran.

Given that AR - V7 has been associated with resistance to hormone therapy but not chemotherapy, the authors speculated that AR - V7 - positive patients should probably be offered chemotherapy rather than hormone therapy as initial treatment for mCRPC.

Both microRNA families have the connection to drug resistance as well as to cancer stem cells, sub-population of cancer cells that have self - renewal properties and the ability to give rise to new tumors that are more resistant to current therapy.

We seek to «Track and Treat» the cancer cells present in patients» tissues by using lineage tracing, as well as sequencing technologies, to determine the molecular mechanisms responsible for the dissemination of cancer cells to various organs, and resistance to current therapies.

The bioinformatics team uses sophisticated algorithms to elucidate markers of response and resistance to therapy, as well as determine how patients can be stratified appropriately for the most relevant therapies under study.»

As MD Anderson moves toward molecular characterization of the cancers of all our patients, allowing their optimal assignments to promising new targeted therapies and potential identification of biomarkers of response and resistance, the department's mission includes thematic translational research and preclinical molecular pathology research.

Similar approaches could be used to study the molecular basis of response to a given therapy, as well as mechanisms of resistance to treatment.

We hope CBS - based combination therapy will open up a new horizon for the treatment of infection caused by superbugs, serving as a new and more economical therapy to solve the problem of antimicrobial resistance (AMR).»

These results show that acquisition of a JAK inhibitor - resistant mutation such as the Y931C in cells dependent on activated JAK2 V617F for growth is a potential mechanism of secondary resistance to JAK inhibitor therapy in MPN patients.

Numerous international publications testify to the research group's commitment to identifying metabolic and molecular pathways as potential targets for innovative therapies that combine nutraceutical intervention and physical exercise, for the prevention and treatment of insulin resistance, of diabetes and associated complications.

These results show that acquisition of a JAK inhibitor resistant mutation such as the F958C in cells dependent on activated JAK1 for growth is a potential mechanism of secondary resistance to JAK inhibitor therapy.

Led by Christiana Davis, MD, (in collaboration with Dr. Peter Gabriel, Chief Oncology Informatics Officer and Abigail Doucette, MPH, Research Registry Program Manager), the Thoracic TCE has established project - based databases to track the demographics and response status of patients to immune - oncology treatments, as well as acquired resistance to standard therapies and novel targeted immunotherapies.

Recent spread of artemisinin resistance and emerging piperaquine resistance in Southeast Asia show that artemisinin combination therapy, such as dihydroartemisinin - piperaquine, are losing clinical effectiveness, prompting investigation of drug resistance mechanisms and development of strategies to surmount emerging anti-malarial resistance.

Background: As the prevalence of artemisinin - resistant Plasmodium falciparum malaria increases in the Greater Mekong subregion, emerging resistance to partner drugs in artemisinin combination therapies seriously threatens global efforts to treat and eliminate this disease.

This work, and that of colleagues Brian Druker and Novartis, led to the development of the kinase inhibitor imatinib (Gleevec) as primary therapy for chronic myelogenous leukemia (CML), and the discovery that imatinib resistance is caused by BCR - ABL kinase domain mutations.

My go - to herbalist, author and American Herbalist Guild member David Winston of Broadway, New Jersey, says in his book, Herbal Therapy and Supplements: A Scientific and Traditional Approach, that animal and test - tube studies are convincing enough to recommend eating maitake regularly as part of a treatment plan for high cholesterol, high blood pressure, insulin resistance, and even hepatitis B. (Placebo - controlled studies in people have yet to be conducted.)

Several studies reviewed indicated that using yoga as therapy combated insulin resistance by improving fasting glucose (with improvements ranging from a 5.4 % to a 33.4 % decrease in fasting glucose levels), postprandial glucose levels (blood sugar levels after meals), and glycohemoglobin levels (a measure of the long - term control of diabetes mellitus).

Some practitioners, however, also use it as part of their therapy and is an example of biofeedback, defined here as a method of improving muscle function and correcting imbalance by consciously responding to the stimulation of pressure resistance by another person (such as a therapist) against a muscle.

Low - dose supplemental testosterone treatment in men with chronic stable angina increased exercise time preceding induced myocardial ischemia as defined by ST depression on EKG.80 Testosterone replacement therapy has also been proven to reduce insulin resistance, visceral adiposity, and cardiovascular risk.

He's not a huge fan of water but has tolerated our request and done really well in the resistance pool for therapy - it's helping relieve some of the extra stress he puts on the front half of his body and is a fantastic workout for him as he does need to lose a few pounds.

'' Fallback measures» can be thought of as the Collaborative Couple Therapy alternative to the concepts of defense and resistance.

As an arts therapist, my choice to pursue another qualification, was informed by the fact that I often witnessed people's resistance when considering the possibility of asking for help and starting therapy.

The need for a protective separation of the child is made necessary on two grounds, 1) to protect the child from continued exposure to the psychological child abuse associated with the pathogenic parenting of the narcissistic / (borderline) parent, and 2) to prevent psychological harm to the child during the active phase of treatment as a result of being turned into a «psychological battleground» by the continued active resistance of the narcissistic / (borderline) parent to the goals of therapy, and from the continued motivated efforts of the narcissistic / (borderline) parent to maintain the child's symptomatic state even as therapy seeks to resolve the child's symptoms.

The emphasis on validation in DBT grew out of observations in the late 1970s that many clients experienced behavioral therapy as invalidating; this led to resistance and sometimes withdrawal from therapy.