Not exact matches
Aug. 30, 2012: The
genome of a recently discovered branch of extinct
humans known
as the Denisovans that once interbred with us has been
sequenced
The entire
genome of the tiny nematode (Caenorhabditis elegans) also has been
sequenced as a ta - ngen = tial study to the
human genome project.
Aug. 30, 2012: The
genome of a recently discovered branch of extinct
humans known
as the Denisovans that once interbred with us has been
sequenced Anyone find fossils of Adam and Eve yet?
The arrangement, he says, is an important first step
as human genome sequencing becomes commonplace.
In February, researchers published the first ancient American
human genome,
sequencing DNA from the remains of a boy known
as Anzick - 1, who was buried about 12,600 years ago in what is now western Montana.
The estimate of the number of
human genes has been repeatedly revised down from initial predictions of 100,000 or more
as genome sequence quality and gene finding methods have improved, and could continue to drop further.
The man responsible for one of the original
sequences of the
human genome as well
as the team that brought you the first living cell running on
human - made DNA now hopes to harness algae to make everything humanity needs.
Their work has made it increasingly clear that for all the popular attention devoted to
genome -
sequencing projects, the epigenome is just
as critical
as DNA to the healthy development of organisms,
humans included.
Data published by the International
Human Genome Sequencing Consortium indicate that somewhere between 113 and 223 genes present in bacteria and in the human genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary extr
Human Genome Sequencing Consortium indicate that somewhere between 113 and 223 genes present in bacteria and in the human genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary ext
Genome Sequencing Consortium indicate that somewhere between 113 and 223 genes present in bacteria and in the
human genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary extr
human genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary ext
genome are absent in well - studied organisms — such
as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary extremes.
The luck continued when Viola's colleagues found that the bone contained well - preserved DNA, and they
sequenced its
genome to the same accuracy
as that achieved for contemporary
human genomes (Q. Fu et al.Nature 514, 445 — 449; 2014).
«We explored the opportunity of using sperm RNA elements
as a predictor of
human health, with applications at the fertility clinic that would go hand - in - hand with the new neonatal intensive care unit genome sequencing to better health outcomes,» said Dr. Krawetz, associate director of the C.S. Mott Center for Human Growth and Develop
human health, with applications at the fertility clinic that would go hand - in - hand with the new neonatal intensive care unit
genome sequencing to better health outcomes,» said Dr. Krawetz, associate director of the C.S. Mott Center for
Human Growth and Develop
Human Growth and Development.
By comparing it with that of modern
humans, chimpanzees and bonobos, plus Neanderthals and Denisovans, Meyer estimated its age at 400,000 years, twice
as old
as our own species and far older than any hominin
genome previously
sequenced (Nature, DOI: 10.1038 / nature12788).
As the cost of
sequencing the
human genome has plummeted in recent years, many medical researchers have touted the potential of personalized medicine — exotic therapies and synthetic drugs that are tailored to our individual genetic makeup.
Boyd et al.
sequenced the
genomes of symbiotic bacteria from
human lice
as well
as the closely related chimpanzee, gorilla and red colobus monkey lice.
Work is expected to begin
as soon
as participants at
genome centers in the United States and abroad agree on some ground rules for the project, perhaps the most unwieldy collaboration since the
sequencing of the
human genome.
As large - scale genome sequencing projects, such as the Human Genome Project, near completion, the research community's focus is shifting toward efforts to determine functional information about these sequenced gene
As large - scale
genome sequencing projects, such as the Human Genome Project, near completion, the research community's focus is shifting toward efforts to determine functional information about these sequenced
genome sequencing projects, such
as the Human Genome Project, near completion, the research community's focus is shifting toward efforts to determine functional information about these sequenced gene
as the
Human Genome Project, near completion, the research community's focus is shifting toward efforts to determine functional information about these sequenced
Genome Project, near completion, the research community's focus is shifting toward efforts to determine functional information about these
sequenced genes.
Both studies relied on a popular lab organism known
as C. elegans, a nearly microscopic nematode that is fast growing, translucent and has a
sequenced genome showing that nearly half its genes are closely related to corresponding
human genes.
As when he worked on the
human genome, Venter is relying on a radical technique called shotgun
sequencing: He chops up vast amounts of DNA into tiny pieces and then uses sophisticated computer analyzers to piece them back together into intelligible genes and chromosomes.
The
sequencing of the first
genome involving a cockroach species may one day serve
as a model system comparable to how research on mice can apply to
humans.
«The quality of this
sequence is comparable to the first
sequencing of the
human genome as published 15 years ago, which revolutionized biomedical research at that time,» enthuses Matthias Platzer — research group leader at the FLI and involved in both the
human and fish
genome sequencing progressions.
Just
as the
Human Genome Initiative in the 1990s sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applicat
Human Genome Initiative in the 1990s
sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applicat
human DNA for the subsequent identification and analysis of genes, so too will the Materials
Genome Initiative
sequence materials for identifying new properties for a variety of applications.
As scientists race to decode
genomes — not just of
humans but of bacteria, yeast, chimps, dogs, whales and plants — the number of DNA
sequences available for analysis has grown 40,000-fold in the past 20 years, providing unprecedented insight into billions of years of species evolution.
[Haemophilus influenzae is a bacterium, the first organism to have its entire
genome sequenced, which Venter completed in 1995; Drosophila is the common fruit fly, whose
genome Venter
sequenced as a warm - up to
sequencing the
human genome.]
This was a daunting task,
as the barley
genome is almost twice the size of the
human genome and 80 percent of it is composed of highly repetitive
sequences, which can not be assigned accurately to specific positions in the
genome without considerable extra effort.
The
human genome, considered
as a mass, contains more retrovirus
sequences than actual genes.
With the completion of the first phase of the
Human Genome Project in 2000, and the advent of
sequencing technologies that can detect gene variations such
as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.
The advent of large - scale
genome sequencing has helped scientists identify DNA bacteriophages in the
human gut, skin and blood
as well
as in the environment, but few researchers have looked for RNA bacteriophages in those samples.
The nematode project is also seen
as an ideal way of perfecting the mapping and
sequencing strategies researchers will need for their final assault on the
human genome, which is some 30 times bigger.
The
genome shares about 60 % of its genes with the other invertebrates completely
sequenced, such
as the nematode and fruit fly, whereas about 5 % match
sequences found only — up to now, at least — in the
human, mouse, and puffer fish
genomes.
When researchers decided to
sequence the
human genome in the late 1990s, they were focused on finding those traditional genes so
as to identify all the proteins necessary for life.
Even
as the
genome sequencing heavyweights scramble to finish a rough draft of the
human genome, they have taken on equally monumental task: churning out a rough draft of the mouse
genome by 2003.
Ever since the
human genome was
sequenced a decade ago, researchers have dreamed about deciphering DNA from our three great ape cousins
as well.
MADISON, WISCONSIN —
As champagne corks popped today in Washington, D.C., over news that the
human genome has been almost completely
sequenced, researchers here quietly learned that their favorite plant's
genome is even further along.
The study, conducted in both
human and mouse cells, shows that cancer
genomes lose copies of repetitive
sequences known
as ribosomal DNA.
Venter: This prize started out
as a half million dollar prize out of the Venter Institute, in part after I
sequenced the first version of the
human genome.
The high degree of similarity between the mouse and
human genomes is demonstrated through analysis of the
sequence of mouse chromosome 16 (Mmu 16), which was obtained
as part of a whole -
genome shotgun assembly of the mouse
genome.
The
human genome contains about 3 billion base pairs, but only about 2 percent of these base pairs represent protein - coding genes, meaning that whole - exome
sequencing measures the genetic alterations focused on a small but very important fraction of the
genome (
as opposed to techniques of whole
genome sequencing, which measures every nucleotide across the entire
genome, regardless of whether these genes are expressed or silent).
He added: «The
sequencing of
genomes from this key region will have a major impact on the fields of palaeogeneomics and
human evolution in Eurasia,
as it bridges a major geographic gap in our knowledge.»
His team discovered these special
sequences are distributed throughout the
human genome, embedded in multiple genes
as shown in the study in Cell Cycle.
«
As the Baylor - Johns Hopkins Center for Mendelian Genomics enters year three of our four year grant, we have found new learning opportunities with each phenotype,» said Shalini Jhangiani, senior project manager in the
Human Genome Sequencing Center and a co-author on the study.
It has launched projects such
as a major effort to develop knock - out mice (ScienceNOW, 7 September 2006) and The Cancer
Genome Atlas (Science, 16 December 2005, p. 1751), which, with the cancer institute, is
sequencing mutations in
human cancers.
As director of Technology Development, she has helped create methods and automation pipelines for
sequencing the
human genome.
He says HGS was getting «diminishing returns» from its investment in TIGR since Venter had steered his outfit into
sequencing organisms of little medical importance, and into
human genome sequencing, also of limited value for a company like HGS that is interested in genes
as drug targets (not untranslated DNA that makes up most of the
genome).
Complete Genomics, a Mountain View, California - based biotechnology company last year claimed it would soon be able to sell full
human genome sequences for
as little
as $ 5000 apiece.
Western Pygmies I love population genetics for its ability to peer back into
human history through the medium of DNA's ATCGs.One of the stars of this discipline is Sarah Tishkoff, a standout in African genetics, someone who will readily haul a centrifuge into the bush in Cameroon.Tishkoff of the University of Pennsylvania is lead author on a paper published online July 26 in Cell that details whole -
genome sequencing of five individuals each from three extant hunter - gatherer groups — the Pygmies of Cameroon
as well
as the Hadza and the Sandawe of Tanzania.
Using a specific work flow, they assessed both the coding and noncoding regions of the
human genome, including the evaluation of highly polymorphic SNPs, structural and copy number variations,
as well
as 69 control
genomes sequenced by the same procedures.
The study broke new ground in other areas
as well, yielding the first ancient whole
genomes of East Asian ancestry and the highest coverage ancient
human genome from Asia (7x coverage)
sequenced to date.
«The availability of the
human genome sequence,
as well
as other genomic resources produced by our
sequencing centers, has transformed biomedical research everywhere,» said NHGRI's Associate Director of Extramural Research Jane Peterson, Ph.D., who is also a program director for NHGRI's Large - Scale Sequencing Researc
sequencing centers, has transformed biomedical research everywhere,» said NHGRI's Associate Director of Extramural Research Jane Peterson, Ph.D., who is also a program director for NHGRI's Large - Scale
Sequencing Researc
Sequencing Research Network.
In 2012,
as part of efforts to better understand the causes of melanoma, researchers at the Broad Institute, the Dana - Farber Cancer Institute and a number of other institutes reported the results of whole
genome sequencing of 25
human metastatic melanomas (Berger et al., 2012).
The
sequencing centers also will focus increased attention on
sequencing the
genomes of organisms, such
as bacteria, fungi, parasites and insects, which cause or transmit
human diseases.