Sentences with phrase «as sickle cell disease»

The long - term vision is to apply these technologies to other genetic diseases, such as sickle cell disease, and to explore applications in developing effective immune therapies for cancer.

Scientists developing new cell therapy methods for the treatment of disorders such as sickle cell disease or leukemia need to consider how their culture conditions may affect the success of their translational research.

ASH is alarmed about the opioid crisis; however, it is concerned about potential adverse effects that policy changes could have on the administration of necessary and appropriate pain medicine for patients with hematologic conditions such as sickle cell disease (SCD), blood cancers, and other bleeding disorders.

If X-SCID can be cured with no serious side effects, that will ease concerns about the risks of using similar vectors to treat other blood diseases such as sickle cell disease, notes Dunbar.

National Institutes of Health Director Francis Collins delivered an upbeat assessment of what lies in store for the world's largest supporter of biomedical research, projecting advances in battling genetic disorders such as sickle cell disease and the development of an atlas of human cells to...

«Comprehensive care is the key to successful management of sickle cell disease, known as sickle cell disease.

Not exact matches

CRISPR gene - editing has already been vaunted as a tool that could eventually be used to tackle everything from HIV / AIDS to sickle cell disease to a variety of other disorders.

In diseases such as malaria and sickle cell disease, red blood cells break down, with harmful effects on the rest of the body — particularly the lining of small blood vessels.

Find out how to manage pregnancy health conditions such as lupus, sickle cell disease, and fibroids, and get help picking a baby name from our list of the most popular African American baby names.

In order for your child to inherit your recessive genetic disorder, such as cystic fibroisis, sickle cell disease, fragile X syndrome or Tay - Sachs, both the male and the female partner have to pass on their copy of the mutated gene.

You should receive a visit from your midwife in your first few days after bringing baby home, where he or she will assess your baby's health, weigh your newborn to ensure they are putting on enough weight and give baby a heel prick test to check for rare conditions such as cystic fibrosis, sickle cell disease and thyroid deficiency.

Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

The Reverend said, however, that while he was struggling to raise the money, the hospital management called to inform him that the Sickle Cell Foundation of Nigeria had contributed N260, 000 to fund the operation as part of its efforts towards the treatment of the disease.

As for why evolution wouldn't have long ago snuffed out this genetic thorn in the side of fertility, Cherr suspects the mutation may also confer some yet - unknown advantage, the way the sickle - cell gene provides malaria protection along with the risk of a deadly blood disease.

A team of researchers at the Stanford University School of Medicine has used a gene - editing tool known as CRISPR to repair the gene that causes sickle cell disease in human stem cells, which they say is a key step toward developing a gene therapy for the disorder.

The classic example is the sickle cell gene — people with one copy of the gene are strongly protected against malaria but those with two copies of the gene develop a life - threatening condition known as sickle - cell disease.

Although treatment for sickle - cell disease with marrow from related donors is now accepted as a standard of care, treatment with marrow taken from an unrelated donor is still evolving, reserved for only the most seriously sick patients.

«When pain was reported as low, sickle cell disease patients reported higher opioid use if they catastrophized, or focused their thinking on their pain, than if they didn't,» says Finan.

Patients with sickle cell disease are commonly prescribed a daily, long - acting painkiller taken at a constant dose, and a short - acting painkiller to be taken as needed for episodes of more severe pain.

Over a period of several months, Hina required as many blood transfusions as she had during a lifetime of sickle - cell disease.

Stem cell treatments are already a reality for diseases of the blood, such as leukemia and sickle - cell anemia (like Paizley's), and for tissue repair of the skin and the cornea.

As a result of the finding, researchers can also use Mauritian cynomolgus macaques to improve stem cell transplant outcomes for human patients with other blood - related conditions such as leukemia and sickle - cell diseasAs a result of the finding, researchers can also use Mauritian cynomolgus macaques to improve stem cell transplant outcomes for human patients with other blood - related conditions such as leukemia and sickle - cell diseasas leukemia and sickle - cell disease.

On the other end of the spectrum are Mendelian diseases such as cystic fibrosis and sickle - cell anemia, which are caused by abnormalities to a single gene.

«Secondary benefits of this trial include the significant improvement in clinical care for children with sickle cell disease at each of the 29 sites because each location had a designated hematologist, neurologist, neuroradiologist and psychologist working as a team to identify and decrease further injury to the brain in this vulnerable population.»

The sickled shape of the hemoglobin in sickle cell disease can impede the journey and often results in oddly shaped, fragile red blood cells as well, said Ikuta.

The scientists did this by manipulating a small molecule known as sphingosine -1-phosphate (S1P), which they report is found in elevated levels in people with sickle cell disease.

Because the deformation of red blood cells is a key factor in the Fåhræus - Lindqvist layer, its properties are altered in diseases, such as sickle cell anemia, that affect the shape and rigidity of those cells.

A number of new clinical trials aim to take cells from a patient, such as blood cells or immune cells, edit them and transfer them back with new power to undermine diseases like cancer or sickle cell anemia.

It explores the mystery of mutated genes in hereditary diseases such as cystic fibrosis and sickle - cell anaemia.

He and other supporters argued unsuccessfully that the move would pave the way to cures for conditions such as spinal cord injuries and sickle - cell anemia as well as degenerative disorders such as multiple sclerosis and Parkinson's and Alzheimer's diseases.

As an example of a disease whose genetic basis not only is felt to be much simpler than that of malignancies, but also is affected by host genomic and environmental complexities, consider sickle cell disease.

Kenneth Ataga, MD, director of the UNC Comprehensive Sickle Cell Program, was featured in a video by the American Society of Hematology in which he discussed the favorable results of a yearlong clinical trial studying crizanlizumab as a therapy to prevent and treat painful crisis events in patients with sickle cell diSickle Cell Program, was featured in a video by the American Society of Hematology in which he discussed the favorable results of a yearlong clinical trial studying crizanlizumab as a therapy to prevent and treat painful crisis events in patients with sickle cell diseCell Program, was featured in a video by the American Society of Hematology in which he discussed the favorable results of a yearlong clinical trial studying crizanlizumab as a therapy to prevent and treat painful crisis events in patients with sickle cell disickle cell disecell disease.

As a firm believer that stem cell science will cure Sickle Cell Disease, she has dedicated a large portion of her life to improving the lives and overall healthcare of those living with the disecell science will cure Sickle Cell Disease, she has dedicated a large portion of her life to improving the lives and overall healthcare of those living with the diseCell Disease, she has dedicated a large portion of her life to improving the lives and overall healthcare of those living with the dDisease, she has dedicated a large portion of her life to improving the lives and overall healthcare of those living with the diseasedisease.

Colleen Dansereau, RN, MSN, CPN Program Manager, Gene Therapy Program As manager of the Gene Therapy Program, Colleen administratively manages the CAR T - cell therapy program as well as all administrative responsibility for all of the gene therapy clinical trials that take place at Dana - Farber / Boston Children's, for conditions including sickle cell disease, Wiskott - Aldrich Syndrome (WAS), and chronic granulomatous disease (CGDAs manager of the Gene Therapy Program, Colleen administratively manages the CAR T - cell therapy program as well as all administrative responsibility for all of the gene therapy clinical trials that take place at Dana - Farber / Boston Children's, for conditions including sickle cell disease, Wiskott - Aldrich Syndrome (WAS), and chronic granulomatous disease (CGDas well as all administrative responsibility for all of the gene therapy clinical trials that take place at Dana - Farber / Boston Children's, for conditions including sickle cell disease, Wiskott - Aldrich Syndrome (WAS), and chronic granulomatous disease (CGDas all administrative responsibility for all of the gene therapy clinical trials that take place at Dana - Farber / Boston Children's, for conditions including sickle cell disease, Wiskott - Aldrich Syndrome (WAS), and chronic granulomatous disease (CGD).

Dr. Haywood also serves as a member of the oversight steering committee for the Health Resources and Services Administration's Sickle Cell Disease Treatment Demonstration Program.

«For example, despite matching the ABO blood group antigens during red blood cell (RBC) transfusion, up to 45 percent of chronically transfused patients, such as those with sickle cell disease or thalassemia, develop antibodies to mismatched minor antigens on transfused RBCs; this process is known as alloimmunization.»

This year's Action Award honorees include global leaders in the fight to end cancer as we know it; a world leader in advancing the emerging field of regenerative medicine and game - changing cell therapy medical treatments; the president of a non-profit group focused on developing cures for chronic, debilitating and fatal diseases; a sickle cell and stem cell advocate and founder / science administrator of the Axis Advocacy; and the founding director of the Institute for Integrated Cell - Material Sciences (iCeMS) at Japan's Kyoto Universcell therapy medical treatments; the president of a non-profit group focused on developing cures for chronic, debilitating and fatal diseases; a sickle cell and stem cell advocate and founder / science administrator of the Axis Advocacy; and the founding director of the Institute for Integrated Cell - Material Sciences (iCeMS) at Japan's Kyoto Universcell and stem cell advocate and founder / science administrator of the Axis Advocacy; and the founding director of the Institute for Integrated Cell - Material Sciences (iCeMS) at Japan's Kyoto Universcell advocate and founder / science administrator of the Axis Advocacy; and the founding director of the Institute for Integrated Cell - Material Sciences (iCeMS) at Japan's Kyoto UniversCell - Material Sciences (iCeMS) at Japan's Kyoto University.

CRISPR / Cas9 could be used to develop therapies for humans for genetic blood diseases such as sickle cell or thalassemia, and this paper does not change that potential.

At the ISSCR 2016 meeting in San Francisco, attendees heard two inspirational stories from Kristin Macdonald and Adrienne Bell - Cors of what it's like to live with diseases such as retinitis pigmentosa (RP), and sickle cell disease, respectively.

As the stem cell field works toward developing treatments for RP, sickle cell and other diseases, the pursuit is strengthened and the process enhanced by the partnership of patients and disease advocates.

The Bone Marrow and Stem Cell Transplant Program is expanding the use of this technique for patients with solid tumors including neuroblastoma and brain tumors; a variety of high - risk hematologic diseases, such as thalassemia major and transfusion - dependent sickle cell disease; and other nonmalignant diseaCell Transplant Program is expanding the use of this technique for patients with solid tumors including neuroblastoma and brain tumors; a variety of high - risk hematologic diseases, such as thalassemia major and transfusion - dependent sickle cell disease; and other nonmalignant diseacell disease; and other nonmalignant diseases.

«As much as we worry about premature or ethical use, using these technologies to get rid of genetic disease would be amazing: Tay - Sachs, cystic fibrosis, sickle cell disease, hemophilia,» Caplan saiAs much as we worry about premature or ethical use, using these technologies to get rid of genetic disease would be amazing: Tay - Sachs, cystic fibrosis, sickle cell disease, hemophilia,» Caplan saias we worry about premature or ethical use, using these technologies to get rid of genetic disease would be amazing: Tay - Sachs, cystic fibrosis, sickle cell disease, hemophilia,» Caplan said.

Gene editing has emerged as a promising strategy to treat diseases like β - thalassemia and sickle cell disease which are both caused by mutations in the gene for β - globin (HBB).

Along with treating children with malignant disease, he also will care for those whose blood disorders are not malignant, such as patients with sickle cell anemia.

Scientists have long viewed in utero blood stem cell transplantation as a promising treatment strategy for many genetic diseases diagnosed as early as the first trimester of pregnancy, including sickle cell disease and certain immune disorders.

What's more, inherited diseases can arise from a problem with one gene (a simple example is sickle - cell anemia, a condition caused by defects in a single gene that makes the hemoglobin protein), or from interactions among a range of genetic variations as well as, frequently, environmental stresses.

Additionally, screening for conditions such as Down syndrome, cystic fibrosis, and sickle cell disease is also a routine offering in prenatal care.

In contrast to Mendelian disorders (e.g., Huntington's disease, sickle cell anemia) in which variation in a single gene causes disease, common complex disorders, such as heart disease, diabetes, and most cancers, develop as a result of both genetic and environmental factors.

After four months, the researchers found that the injected cells had integrated themselves in the mice's bones as they had hoped; if the same were true in humans, it could mean a treatment, or even a cure, for sickle cell disease.