Sentences with phrase «as skeletal muscle»

Baclofen is a human medication used as a skeletal muscle relaxant.

Hookworms can penetrate the skin and cause cutaneous larva migrans, although in rare instances visceral larva migrans can also occur, as well as skeletal muscle or intestinal involvement.

Excitable cells, such as skeletal muscle and nerve cells, contain voltage - dependent calcium channels in their cell membranes that allow for rapid changes in calcium concentrations.

Human brains, unique amongst animals, can use ketones as a major fuel source during prolonged starvation, allowing the conservation of protein such as skeletal muscle.

«Proteins are broken down into amino acids and used by the body for everything from creating enzymes, immunoprotectors, transporter molecules, and structural elements, such as skeletal muscle,» he says.

Upon binding to targeted cells such as skeletal muscle and brain cells, glucagon acts to decrease the amount of glucose in the bloodstream.

As far as skeletal muscle growth is concerned, carbs and protein are more anabolic than dietary fat.

The protective effects were seen in both the diaphragm, the primary muscle used for breathing, as well as skeletal muscle.

This is associated with modification of hypothalamic nitric oxide release that favors glucose uptake in metabolic tissues such as skeletal muscle, liver, and adipose tissue.

The gene, known as gata5, acts in embryonic cells, which are primordial, unspecialized cells that form in the earliest stage of embryonic development and are genetically programmed to evolve into one of many specialized cell types, such as skeletal muscle cells, nerve cells, blood cells, skin cells, and liver cells.

«The vitamin D receptor is expressed in insulin - secreting pancreatic beta cells and in peripheral target tissues such as skeletal muscle and adipose tissue.

«Under no circumstances should it be concluded from our work that consumption of marijuana can be a way to cure diabetes,» Prof. Dobrzyn warns and explains: «The concentration of glucose in the blood is determined by the balance between the activities of alpha and beta cells of the pancreas and insulin target tissues such as skeletal muscle and adipose tissue.

Fibrodysplasia ossificans progressive (FOP) is a rare, but devastating genetic disease where bone is grown within soft tissue, such as skeletal muscle.

But heart tissue is not known for being as resilient as skeletal muscles or skin.

Not exact matches

Post-race, the blood of a marathoner can paint a picture of diseased organs and biochemical decay thanks to compounds tossed off by the skeletal muscle, heart, and liver, such as troponin, a cardiac enzyme whose elevation signals trauma to the heart.

Because the growth plates at the end of the major bones in a child's arms and legs are open, their muscles and bones are still developing, and because their hormone levels aren't the same as adults, an intense strength and conditioning program is inappropriate before skeletal maturity.

There are also different versions of AAV that can preferentially go to different tissues, such as skeletal and cardiac muscle, so researchers can deliver them systemically.

Multi-nucleus cells expressing genes needed to form skeletal muscle can be seen in flower - like clumps forming as cells fuse together.

Specialized stem cells known as satellite cells reside in skeletal muscle in an inactive state.

The investigators found that when LIF - treated muscle stem cells were transplanted to skeletal muscle, they formed two to three times more muscle fibers as control cells did.

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

Among the 19 study volunteers who lost 5 percent of their body weight, the function of insulin - secreting beta cells improved, as did insulin sensitivity in fat tissue, liver and skeletal muscle tissue.

As researchers develop drugs that target the DUX4 protein, the hope is that these mice will be used to determine whether such drugs can reach skeletal muscle and allow muscle damage to be repaired, even in the presence of DUX4.

Patients affected by this genetic condition suffer from wasting of skeletal muscles as well as arrhythmia and other cardiac dysfunctions.

Results of a study conducted by researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine showed significant improvement in strength and range of motion, as well as evidence for skeletal muscle regeneration, in 13 patients who were surgically implanted with bioscaffolds derived from pig tissue to treat muscle injuries.

Ischemia / reperfusion injury underlies health issues such as heart attack, stroke, and numerous other ailments including diseases of the kidney, liver, skeletal muscles, and more.

Whitesides is now also looking at fastening these actuators to hard skeletal frames to see if they can work as muscles in rigid - bodied robots too.

Glass's team next used a combination of chemicals to injure a mouse's skeletal muscles, and then regularly injected the animal with three times as much GDF11 as Wagers and her team had used.

For instance, each fiber in a skeletal muscle can contract separately, which allows to control movements as well as muscle strength very precisely.

Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells.

Published this week in the journal Proceedings of the National Academy of Sciences, the scientists found that inhibiting activin A, activin B and myostatin resulted in skeletal muscle mass increase by as much as 150 per cent in preclinical models.

In skeletal muscle, fast - twitch glycolytic fibers use glycogen as the main energy source for anaerobic metabolism, serving to sustain brief periods of high - intensity activity.

Myostatin has long been recognised as the body's major negative regulator of skeletal muscle mass, helping to maintain muscle homeostasis in the body, but creating molecules to target all three related proteins together was a novel approach.

Using new technologies, including XROMM (x-ray reconstruction of moving morphology), which combines 3D skeletal models with x-ray video, as well as micromeasurements of muscle movement taken with thin - walled metal tubes that are visible with x-ray fluoroscope, the team reveals just how stretchy those tendons are.

As people become overweight, their skeletal muscle develops insulin resistance that can lead to type two diabetes.

In tissues such as liver and skeletal muscle, FAO can provide over 75 % of cellular adenosine triphosphate, while in cardiac tissue it can be responsible for up to 90 %.

Hence, FLRG is capable of increasing muscle growth in a dose - dependent manner when expressed as a transgene in skeletal muscle.

As stem cells continue their gradual transition from the lab to the clinic, a research group at the University of Wisconsin — Madison has discovered a new way to make large concentrations of skeletal muscle cells and muscle progenitors from human stem cells.

The peripheral nervous system of vertebrate animals includes three kinds of nerve cells: sensory neurons, which transmit impulses from sensory receptor structures to the brain; motor neurons, which innervate the striated, or skeletal, muscles, and autonomic neurons, which regulate the functional activity of the circulatory system, the organs, the glands and the smooth muscles (such as those of the intestine).

Our data demonstrate that loss of IL - 15Rα results in a remodeling of fast skeletal muscles to a more oxidative phenotype that manifests as a greater exercise capacity and resistance to fatigue in mice due, in part, to adaptations in mitochondria — phenotypes that were only observed in IL - 15Rα — KO mice.

In addition, the altered rates of force development and relaxation suggest alterations in the regulation of intracellular calcium levels following maximal contractions, as are noted to occur in slow skeletal muscles (44).

Once the fruit flies return from the ISS, comprehensive measurements of cardiac function will be taken, including climbing assays to measure skeletal muscle function, heart function assays as well as genetic assays.

Mice engineered to carry a deletion of the Mstn gene have about a doubling of skeletal muscle mass throughout the body as a result of a combination of muscle fiber hyperplasia and hypertrophy [2].

Resistance to repeated contraction - induced fatigue is a hallmark characteristic of slow skeletal muscles such as the soleus and is due to a combination of increased mitochondrial volume, oxidative enzyme capacity, capillarity, and smaller muscle fiber sizes.

The upregulation of Il15 mRNA in skeletal muscles from IL - 15Rα — KO mice reported in the current study could potentially contribute to the altered body composition observed in these mice (14), as HSA - IL - 15TG mice had lower adiposity and were resistant to high - fat diet — induced obesity (34).

I have presented data showing that FLRG, like follistatin, can promote muscle growth when expressed as a transgene in skeletal muscle and that both of these molecules appear to act by blocking not only myostatin but also other ligands with similar activity to myostatin.

These results imply that mutations in the gene encoding RyR1 will not only affect skeletal muscles, but other tissues that express this calcium channel as well, thereby broadening the clinical spectrum of disorders due to RyR1 dysfunctions.

Using mouse skeletal muscle stem cells as a model, we show that accumulating transcripts specifying the myogenic program are not translated in quiescent satellite cells, but are repressed by the action of microRNAs and RNA binding proteins.

He added that this finding also means that muscular dystrophy (MD) researchers who are attempting to develop genetic therapies must target defective smooth muscle as well as the malfunctioning skeletal muscle most often associated with the crippling effects of the disease.

A second line of research is to use skeletal muscle formation in the chick embryo as a model to understand how cells within tissues display complex behaviours while being exposed to an ever - changing cellular environment.