Sentences with phrase «as small molecule drugs»

3BP, part of a class of compounds known as small molecule drugs, was first studied as an anti-cancer agent more than a decade ago at Johns Hopkins by biochemists Young Hee Ko and Peter Pedersen, together with radiologist Jeff Geschwind.

Not exact matches

The new research, published recently as two separate studies in ACS Central Science and the Journal of the American Chemical Society, demonstrates that a new class of drugs called small molecule RNA inhibitors can successfully target and kill specific types of cancer.

In their ACS Central Science study, Disney and his colleagues used DNA sequencing to evaluate thousands of small molecules as potential drug candidates.

Unpublished results from the researchers hint that significantly fewer anomalies are seen in iPS cells created via virus - free reprogramming strategies, such as ones that use proteins or small - molecule drugs.

The smart gel could provide structural rigidity in organs such as the lungs, and can contain small molecules like water or drugs to be transported in the body and released.

One potential treatment approach could involve linking a cytotoxin to a specific protein binder (as a small - molecule drug conjugate or SMDC).

This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

Small molecule drugs can be screened or designed to increase telomerase activity exclusively within stem cells for disease treatment as well as anti-aging therapies without increasing the risk of cancer.

As a postdoctoral researcher at Harvard Medical School, he investigated the use of small - molecule drugs to manipulate signaling pathways to enable otherwise senescent progenitor cells of the cochlea to divide and form new sensory cells.

In principle, if further tests bear out the protective effects of the two antibodies, then optimized versions of them, or small - molecule drugs that hit the same target, could be developed as treatments for rhinovirus infections.

According to Monk and Ackerman, possible future work includes using the zebrafish model system as a drug - screening tool to search for small molecules that may flip that switch.

«Together, our findings indicate that these molecular regulators, TRIP - Br2 and GATA3, could be viable targets for small drug molecules that could serve as potential therapeutic agents against obesity,» Liew said.

The researchers say the next step is to develop small molecules or drugs that regulate p75 NTR to reproduce this effect and potentially serve as a therapeutic intervention for obesity and metabolic syndrome.

Small molecules (100 - 800 Daltons) have a variety of biological functions, serving as cell signaling molecules, as tools in molecular biology, and as drugs in medicine.

Not a light read, this tome is bursting with information about monoclonal antibodies, from the history of how these therapies were first developed to new approaches such as conjugate therapy, which combines antibodies with small - molecule drugs.

That produced a class of drugs known as angiotensin - converting enzyme, or ACE, inhibitors that hit the market in the early 1980s, and during the next 25 years or so, there followed a string of blockbuster small - molecule drugs that included such familiar names as Lipitor, Zantac and Prozac.

In 1994, Schreiber and co-workers discovered that the proteins FKBP12 and mTOR are the simultaneous targets of the small molecule rapamycin, now approved for use as an immunosuppressant drug given to patients after organ transplantations to help prevent rejection.

He served as Laboratory Director at biotech company, Prosetta Corporation, leading several small molecule drug discovery programs focused on viruses of interest to the United States Department of Defense.

Orders of magnitude more sensitive than conventional Raman microscopy, they allow mapping of 3D distributions of small molecules, such as metabolites and drugs, as well as tumor identification in tissues, which open many exciting new possibilities for biology and medicine.

An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.

The Unit's scientific mission covers the design, synthesis, molecular modeling, as well as biophysical, biochemical and cellular studies of small - molecule probes and drug candidates targeting nucleic acids or proteins involved in cancer.

Because SLC6A14 is essential for tumour growth yet dispensable for normal development and tissue maintenance, small molecules that block amino acid import through this transporter could be effective and selective anti-cancer agents, particularly as components of rational drug combinations.

These alternate strategies include using small - molecule drugs that affect RNA metabolism or protein stability, as well as administering modified viruses for therapeutic gene delivery (see «Getting a fix on SMA»).

By default, that's already the case for small - molecule drugs such as the ones under development at Repligen and Roche.

An evaluation of small - molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells.

As reported online in PLoS One on October 3, Hopkins colorectal cancer specialists John Abraham, Ph.D., and Stephen Meltzer, M.D. - working with the notion that small molecules generally make better treatment packages - designed small bits of protein only 10 amino acids long as the foundation for their drugAs reported online in PLoS One on October 3, Hopkins colorectal cancer specialists John Abraham, Ph.D., and Stephen Meltzer, M.D. - working with the notion that small molecules generally make better treatment packages - designed small bits of protein only 10 amino acids long as the foundation for their drugas the foundation for their drugs.

Therefore, these tiny microRNAs can potentially be used to treat complex diseases as AMD without having to perform extensive screening for small molecule drugs.

eFFECTOR is pioneering a new class of small molecule drugs that act by selectively regulating translation, also known as protein synthesis.

These small molecules interrupt the pathway that confers resistance to aminoglycoside drugs such as kanamycin.

As part of the global effort toward malaria eradication, phenotypic whole - cell screening revealed the 2 - aminopyridine class of small molecules as a good starting point to develop new antimalarial drugAs part of the global effort toward malaria eradication, phenotypic whole - cell screening revealed the 2 - aminopyridine class of small molecules as a good starting point to develop new antimalarial drugas a good starting point to develop new antimalarial drugs.

As the drug enters your system, it breaks down itself into small molecules that is enough to pass through your body's cell mainly because as mentioned earlier, every cell in our body have receptors for steroids called androgen receptor which is where the steroid molecules binAs the drug enters your system, it breaks down itself into small molecules that is enough to pass through your body's cell mainly because as mentioned earlier, every cell in our body have receptors for steroids called androgen receptor which is where the steroid molecules binas mentioned earlier, every cell in our body have receptors for steroids called androgen receptor which is where the steroid molecules bind.

As the drug enters your system, it breaks down itself into small molecules that is enough to pass through your body's cell mainly because as mentioned earlier, every cell in our body have receptors for steroids callAs the drug enters your system, it breaks down itself into small molecules that is enough to pass through your body's cell mainly because as mentioned earlier, every cell in our body have receptors for steroids callas mentioned earlier, every cell in our body have receptors for steroids called

It discovers and develops novel, small - molecule drugs for the treatment of inflammatory and autoimmune diseases, as well as muscle disorders.

Rigel Pharmaceuticals, Inc is a clinical - stage drug development company that discovers and develops novel, small - molecule drugs for the treatment of inflammatory / autoimmune diseases, as well as for certain cancers and metabolic diseases.