Sentences with phrase «as suppressors»

The player will be given specific guns at the beginning of each level, but may switch them out with another gun they find.Most guns have attachments, such as suppressors, and heartbeat sensors.The player can also use grenades and flashbangs when faced with a large group of enemies, as well as a knife for close quarters combat.In some levels, the player will be given special equipment, such as night vision goggles, or a laser designator.

The default loadouts are pretty sparse at the start, but if you stick with one weapon over time, it'll accumulate experience that feeds into a leveling system that governs special unlocks for that gun, such as suppressors, sights, extended magazines, and other useful weapon boosts.

According to Eckmann, «The special thing about these processes is that they involve known molecules with very long evolutionary histories, previously receiving attention as suppressors of tumour formation within the context of normal cell division.

Their finding — that the presence of high levels of NF - κB in lung cancer tumors can act as a suppressor — provides new insight into how tumor pathways regulate the anti-tumor response.

A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

As mentioned in the beginning of this section, the «longevity gene» FoxO3a functions as a suppressor of PCSK9 gene expression when the FoxO3a transcription factor can enter the cell nucleus.

A person will act as a leader who gives the tone early, someone else acting as a suppressor in charge of pressure high or low tone, someone else acting as a solo singer, and someone else will act as the mastermind behind that to deliver the story.

This suggests that one or more of the social competence variables acts as suppressor on gender and that with social competence level kept constant differences between boys and girls in trajectory group membership do occur.

Not exact matches

Results showed that suppressors were judged less likable — as well as less extroverted and agreeable — than people who emoted naturally.

The red suppressor is for small grains and the gray suppressor is for large grains such as beans.

Breastmilk also contains endorphins, which are hormones that act as pain suppressors in an infant.

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

PTEN is known as a tumour suppressor gene meaning that it typically slows the growth of cells and its loss can lead to cancer.

«Our study identified miR - 182 as a glioblastoma tumor suppressor that reduces the expression of several oncogenes that promote cancer development,» said senior author of the study Alexander Stegh, an assistant professor in the Ken and Ruth Davee department of neurology and of medicine at Northwestern University Feinberg School of Medicine.

Correspondingly, a large number of genes with no direct role in tumor progression also are deleted as a result of their proximity to tumor suppressor genes.

EDD1 is an E3 ubiquitin ligase involved in degrading cellular proteins, while TIP60 act as a tumor suppressor protein, and can both be found in the human body.

A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.

«Several studies and clinical evidence suggest AIM2 functions as a tumor suppressor, but until now, we've had very little direct evidence to explains how this occurs,» said Justin E. Wilson, PhD, the study's first author and a postdoctoral fellow at UNC Lineberger, the UNC School of Medicine Department of Microbiology and Immunology and the Department of Genetics.

Rb acts as a tumor suppressor.

But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

«These findings reveal a unique fulvestrant signaling process involving the increased regulation of hsa - miR - 765 that suppresses the HMGA1 protein as part of the mechanism underlying the tumor suppressor action in prostate cancer.

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.

«It wasn't known whether miR - 486 functioned as an oncogene or a tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.

Sweatt speculates that H2A.Z plays a role in modulating memory, serving as a sort of memory suppressor in cases of unpleasant or painful memories.

But it's much harder to develop therapies that restore malfunctioning genes that should be triggering cell death in abnormal cells, known as tumor - suppressor genes.

BRCA1 and 2, genes whose proteins are supposed to work as tumor suppressors and also repair DNA damage, were the first known risk factor genes for familial breast cancer as well as ovarian and other cancers.

«Also, because Notch is known to be a tumor suppressor, the essential role of Rumi in Notch activation suggests that Rumi could be a tumor - suppressor as well.

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus - like eremophytes instead of normal plants from the drought).

Although other tumor suppressors exist, what makes Par - 4 so special is that it is not mutated as frequently as other known suppressors, and it's «selective» in its actions in that Par - 4 will only kill cancer cells and not normal cells.

If the targeted RNA encodes a tumor suppressor protein, as scientists have found for some, the ultimate effect of the microRNA could be to promote cell — and tumor — growth.

Center for Elephant Conservation, elephants have 38 additional modified copies (alleles) of a gene that encodes p53, a well - defined tumor suppressor, as compared to humans, who have only two.

After the KRAS mutation was induced by the researchers, other mutations in what are known as tumor suppressor genes developed.

«This function for BAI1 may have implications for cancer biology, since MDM2 can function as an oncogene by degrading important tumor suppressors like p53.»

Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.

This phenomenon could result in breakage in the human genome, and when a breakage impacts important genes, such as tumor suppressors, it could lead to cancer development.

Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast cells, acting as a tumor suppressor that halts abnormal cell growth.

«These results showed us that epithelial TRPV1 normally works as a tumor suppressor in the intestines,» said de Jong.

«HOXA5 protein acts as tumor suppressor in breast cancer, lab cell study shows.»

Or stem cells injected into a patient as therapy might be designed so that their tumor suppressor genes are less likely to mutate and cause cancer.

This causes genomic instability in developing immune cells and, in the absence of a working tumor suppressor protein such as p53, an aggressive form of lymphoma develops in mice.

That will include validating some of the new predicted tumor suppressors and oncogenes as well as «making some deletions and amplifications and seeing if they have the properties we think they do,» said Elledge.

In humans, cancer develops when genes that suppress cancer, known as tumor suppressors, are lost and when mutations or genes that promote cancer, known as oncogenes, are gained or activated.

Now, researchers at The Wistar Institute have discovered how STAT3 behaves in immature myeloid cells known as myeloid - derived suppressor cells (MDSCs), and they believe they have found the basis for a much more effective method of using STAT3 inhibitors to stop cancer progression in its tracks.

But the idea fell out of fashion as researchers began to discover that mutations in specific oncogenes and tumor - suppressor genes could set cancer in motion.

In this study, published in the journal Cell Reports, and led by Dr. Esteban Ballestar (IDIBELL), the comparison of the epigenetic profiles between dendritic cells and myeloid - derived suppressor cells has allowed them to identify the existence of specific epigenetic alterations that associated with the development of myeloid - derived suppressor cells as a result of exposure to prostaglandin E2.

Intriguingly, previous research found that RASAL2 was lost in some of the luminal type of breast tumours, where it acts as a tumour suppressor.

Rather than a tumour suppressor, we show here that RASAL2 actually acts as a cancer promoting molecule in TNBC.

These findings show that MAX acts as a tumor suppressor gene in one of the more aggressive types of lung cancer.