Sentences with phrase «as surrogate markers»

Clustering of risk factors varies between sexes and ethnicities, but abdominal obesity and increased WCR as surrogate markers seem to be the dominant factors in women (34 — 36).

«We hope that our work will provide the basis for a larger study of patient samples that may ultimately identify biomarkers that can be used as surrogate markers to determine the benefit of therapeutic interventions in diagnosed but asymptomatic HD patients to prevent or delay disease onset.»

Sood and colleagues looked at samples from 80 cases of human ovarian cancer grouped according to patient stress using the National Institutes of Health's Center for Epidemiological Studies Depression scale as a surrogate marker.

Our objective was to develop an eco-epidemiological modeling approach to characterize the spatial relationships between areas of higher than expected ALS incidence and lake water quality risk factors derived from satellite remote sensing as a surrogate marker of exposure.

Therefore, the possibility that coffee consumption may be acting as a surrogate marker of some other dietary or lifestyle risk factor can not be fully excluded.

Not exact matches

These recommendations are based largely on a body of research that links higher sodium intakes to certain «surrogate markers» such as high blood pressure, an established risk factor for heart disease.

To determine whether expression of PD - L1 in nephrectomy specimens can be used as a surrogate for expression in the sites of metastases (and vice versa), we examined the correlation of marker expression (mean AQUA scores for all four cores) between the matched specimens using the Pearson correlation test.

Support to date for the existence of an hypoxic niche in marrow blood stem cells came from indirect evidence such as expression of the hypoxia protein Hif - 1 and related genes and staining with surrogate markers of hypoxia.

However, recent evidence indicates that apoE4 expression compromises the blood - brain barrier (as does apoE deficiency).40 Studies of brain histology, neurodegenerative markers, cholinergic activity, and neuronal function in knockout mice have been equivocal.39 Failure of detailed neurocognitive and retinal studies to demonstrate defects in our patient suggests either that the functions of apoE in the brain and eye are not critical or that they can be fulfilled by a surrogate protein.

Most importantly, the three clinical intervention trials with colon polyp recurrence as an end point also failed to show a protective effect against this surrogate marker for colon cancer (Alberts et al., 2000; Bonithon - Kopp et al., 2000); Schatzkin et al., 2000).