Not exact matches
Learning more about how synapses change their connections could help scientists better understand neurodevelopmental disorders such
as autism, since many of the genetic alterations linked to autism are found in genes that code for
synaptic proteins.
The structure of synaptophysin suggests that the
protein may function
as a channel in the
synaptic vesicle membrane, with the carboxyl terminus serving
as a binding site for cellular factors.
In subsequent research at the Stowers Institute, Si and his team identified Orb2
as the fruit fly version of the CPEB
synaptic protein.
It has been known for decades that triggering new
protein synthesis is vital to the formation of long - term memories
as well
as for long - lasting
synaptic plasticity — the ability of the neurons to change the collective strength of their connections with other neurons.
To determine whether the
protein in question, at the time known
as BNPI, mediated the transport of glutamate into
synaptic vesicles, the researchers inserted the BNPI DNA into rat cells that normally lacked BNPI
protein.
All major
synaptic protein classes were observed, including components of important pre - and postsynaptic complexes
as well
as low abundance signaling
proteins.