Sentences with phrase «as synaptic pruning»

Not exact matches

In particular, widespread «synaptic pruning» — a sort of scaling down of connectors between neurons — reshapes the brain as a child transitions to adulthood.

Specifically, converging lines of evidence suggest that mechanisms such as oxidative stress and extracellular matrix (ECM) deficit may contribute to the functional impairment of PV neurons, leading to aberrant developmental synaptic pruning of prefrontal cortex neural circuitry and hence a failure in the maintenance of synaptic stability.