Sentences with phrase «as targeted therapy»

The drugs known as targeted therapy help stop cancer from growing and spreading.

As successful as targeted therapies are, «they aren't curing people,» Swanton says.

As targeted therapies take center stage in cancer treatment, they are profoundly changing the way research is done.

As such, pharmacogenomic testing becomes fundamental to the development and clinical use of several molecular diagnostics as well as targeted therapies.

Currently, immunotherapy is approved by the Food and Drug Administration (FDA) to treat kidney cancer patients only after they've tried more traditional therapies, such as targeted therapies killing the cancer's blood supply.

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

Not exact matches

Luxturna is the first of a crop of treatments that target diseases caused by mutations in specific genes, and thus is referred to by many as the first gene therapy in the U.S.

The Kamens claim the main thing that distinguishes their foundation from other brain tumor foundations is their focus on pediatric brain cancer specifically, as well as their close ties with pharmaceutical and biotech companies working in the fields of immunotherapy and target gene therapy.

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

I also sought firms targeting opportunities where existing therapies had some shortcoming, as well as those with what I saw as a strong product pipeline.

Incyte's (NASDAQ: INCY) Jakafi racked up $ 1.1 billion in sales last year as the only targeted therapy for patients with myelofibrosis, but a majority of patients who take it eventually relapse.

Peripheral inflammatory responses may, then, serve as biomarkers and thus serve as targets of immune - based therapies for depression.

When I started, I was assigned to read the following paper: «Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury» (Ji et al., 2012).

«For us, it's very important to understand the neural circuits or pathways so that we can develop therapies specifically for pain or itch, instead of targeting it as a whole system,» says Santosh Mishra, assistant professor of neuroscience in NC State's College of Veterinary Medicine and the corresponding author of a paper on the topic.

Drugs that target VCP are already being developed as potential therapies for cancer.

«The most exciting result is the discovery of PGC1 - alpha as potential new target of therapy for early intervention Scherzer,» says.

As the first targeted therapies edge towards regulatory approval, attention turns to the next drugs in line.

The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient's response to therapy.

They note that targeting inflammation to treat infections offers an advantage over antibiotic therapy, as the former hinders gene transfer and the evolution of pathogens, while the latter promotes bacterial evolution and, ultimately, antibiotic resistance.

Currently, many patients who acquire resistance to EGFR - targeted therapy undergo a tumor biopsy and are designated as either positive or negative for specific secondary mutations.

Prof. Severine Vermeire (KU Leuven / UZ Leuven): «In the future, gut bacteria may be used to help identify PSC patients with a more or less aggressive disease, or patients that may benefit from microbiota - based therapies, such as fecal microbiota transplantation or targeted pre - and probiotics.»

However, not everyone's melanoma will benefit equally from MAPK - targeted therapies, and initial benefits might wane over time as tumors develop resistance to treatment.

For example, some cancer treatments, such as HER - 2 targeted therapies, can cause weakening of the heart muscle, a condition known as heart failure.

«Our results suggest that we've been looking at these cancer drugs the wrong way — as tumour - targeting drugs — instead of what we now feel is their most important biological role: as immune stimulating therapy.»

Therefore, common treatments such as endocrine therapy and molecular targeting of the HER - 2 receptor are not effective for this breast cancer subtype.

«Our findings offer new directions for targeted therapies for children with eczema,» says Amy Paller, MD, co-senior author and dermatologist at Ann & Robert H. Lurie Children's Hospital of Chicago, as well as Chair of Dermatology and Professor of Pediatrics at Northwestern University Feinberg School of Medicine.

«It is anticipated that this novel compound will have significant efficacy in human melanomas and other cancers either as a stand - alone therapy or in combination with other targeted or immune - based therapies,» explained co-corresponding author Rhoda Alani, MD, the Herbert Mescon Chair of Dermatology at Boston University School of Medicine (BUSM).

They give some clues about why these diseases occur, but more detailed maps, such as this, will pinpoint where the problems lie — providing precise targets for therapies.

As promising new therapies such as those directly targeting survivor motor neuron (SMN) are entering clinical trials for infants, children, and adults with SMA, researchers are searching for biomarkers in blood that can monitor their effectivenesAs promising new therapies such as those directly targeting survivor motor neuron (SMN) are entering clinical trials for infants, children, and adults with SMA, researchers are searching for biomarkers in blood that can monitor their effectivenesas those directly targeting survivor motor neuron (SMN) are entering clinical trials for infants, children, and adults with SMA, researchers are searching for biomarkers in blood that can monitor their effectiveness.

«Identifying NTM as one of the triggers will hopefully provide a clue to the future development of a targeted therapy for these patients,» he added.

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

Targeted therapy using MDSC - inhibiting drugs, such as cabozantinib (Cabo) and BEZ, also demonstrated minimal anti-tumor capabilities.

«It is expected that this study will lay the foundation for developing a new class of potent and effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.

«Inhibiting mTOR signaling using everolimus, a targeted therapy, known as a rapalog, for patients with lung and gastroenteropancreatic NETs, has been approved by the FDA.

My cancer systems biology team at the University of California, Merced, is tackling diagnosis and treatment of therapy - resistant cancers by elucidating the network of changes within cells as a way to identify new drug targets and circumvent cancer resistance.

Mutations to these genes can affect the choice of therapy as well as how to better target the mutations.

Over the past 2 decades, few effective treatments for this cancer type have been identified, as PanNETs» heterogeneity has complicated the design of targeted therapies.

Researchers said the importance of collecting tissue samples from recurrent tumors will grow as more targeted therapies become available.

These results not only show promise on a new targeted therapy to treat this malignancy, as PI3K inhibitors are already used in the clinical practice, but also unravel a new function of the PI3K kinase in cancer biology through its role in promoting metastasis.

«New targeted therapies such as that proposed in this study (decrease in inflammation) will certainly improve the quality of life of patients by increasing their mobility.»

But as noted in a recent Science news story, targeted therapies don't work as well on solid tumors, which usually develop resistance and start growing again.

Patients with ALK rearrangements do not respond to EGFR - TKIs, but are sensitive to other targeted therapies (such as ceretinib).

Dr. Lazaridis says this molecule therefore should be further examined as a target of therapy for the disease.

This is crucial because therapies, such as cancer drugs, can target histones.

Taken together, the results suggest a role for bile duct tissue microbiome in development of CCA and which may accordingly be used as a target for therapy.

Specific therapies that target a mutation can improve outcomes, such as reducing the risk of death or lessening the severity of disease.

As the principal regulator of iron, hepcidin has become a target for researchers developing novel therapies for blood disorders.

«This brings these members of the epothilone class within range of suitability as payloads for antibody - drug conjugates, a new paradigm for targeted cancer therapy.»

The same process has been studied as a potential genetic therapy for more than a decade, because you can target any disease gene with matching dsRNA.