Sentences with phrase «as the laboratory mouse»

This species has served as the laboratory mouse of botanical research.

Not exact matches

«The 20th century's Thomas Edison has stepped from the stage... the scope of the technologies that sprang from or were transformed by Jobs's Apple laboratories — the Mac, the mouse, the laptop, Pixar, iTunes, iPod, iPhone, iPad — is awesome, as was that from Edison's Menlo Park.»

But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have used the genome - editing technology to cure adult laboratory mice of an inherited liver disease by correcting a single «letter» of the genetic alphabet which had been mutated in a vital gene involved in liver metabolism.»

In 2014, highly publicized work in the laboratories of Villeda and Tony Wyss - Coray, PhD, professor of neurology at Stanford, showed that connecting the circulatory system of a young mouse to that of an old mouse could reverse the declines in learning ability that typically emerge as mice age.

This study identifies myomerger as a fundmentally required protein for muscle development using cell culture and laboratory mouse models.

Since these mice are useful for tasks such as ascertaining the safety of drugs or investigating the cause of a disease, they are frequently transported to laboratories around the world.

Recent laboratory work from Virginia Tech University scientists found that when mice are exposed, both males and females have some unsettling impacts, such as weaker sperm and decreased ovulation.

Biologists have found a virus that causes obesity in laboratory animals, such as chickens and mice.

Apart from a few studies in mouse models and in cell lines, there is no laboratory evidence that synthetic phosphoethanolamine works as a cancer drug.

Recently, Dr. Cohen's laboratory obtained an ethical approval to test the therapeutic efficiency of NT219 as a treatment in Alzheimer's - model mice, hoping to develop a future treatment for hitherto incurable neurodegenerative disorders.

The research was done with laboratory mice that consumed different diets and then faced a variety of tests, such as water maze testing, to monitor changes in their mental and physical function, and associated impacts on various types of bacteria.

In research published in Molecular Cell, Rutgers scientists discovered that a protein (p62), which is supposed to act as an antioxidant to prevent cell damage, was not working efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humans.

Their work with laboratory mice also provides a greater understanding of how this gene impacts Menkes disease as scientists search for a treatment.

As an example, Martin von Lohuizen of the Netherlands Cancer Institute, says Berns's own laboratory has developed a mouse with a gene called PIM1 which rarely causes tumours but sensitises the mouse to the action of a second carcinogen.

«Our stem cells also survive outside of mice, in a culture, so we can also manipulate them in a laboratory,» said Abad, adding that: «The next step is studying if these new stem cells are capable of efficiently generating different tissues such as that of the pancreas, liver or kidney.»

A team of neuroscientists has identified a protein in laboratory mice linked to impairments similar to those afflicted with Angelman syndrome (AS)-- a condition associated with symptoms that include autism, intellectual disability, and motor abnormalities.

«The one thing that I think that is useful is maybe when people write knockout papers they might describe the housing conditions in more detail,» says Chris Paszty, scientific director at the biotech company Amgen, Inc., headquartered in Thousand Oaks, Calif., who as a postdoctoral researcher at Lawrence Berkeley National Laboratory developed a mouse model for the study of sickle cell anemia.

C57BL / 6 wild - type mice (The Jackson Laboratory, 000664; n = 8) were used as an additional control for comparison purposes, but were not included in any statistical analyses.

Additionally, organizations such as Freiburg - based Oncotest, a company founded and directed by Fiebig, and the Jackson Laboratory in Bar Harbor, Maine, provide access to a wide range of PDX mice made from donated tumor tissue.

The HZI will also provide access to laboratory and animal facilities up to BSL3 and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

But while most PDX mice are used as general models of human cancer in the laboratory, others seek to use them as Fiebig originally hoped — as avatars to guide customized patient care.

Finally, Dr. Goldenring's laboratory is also investigating the role of Rab25 as a tumor suppressor in the colon using the Rab25 - / -; Smad3 + / - mouse model, which develops spontaneous invasive distal colon cancers.

Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.

By carefully guiding the cells» choices at each fork in the road, Loh and Chen were able to generate bone cell precursors that formed human bone when transplanted into laboratory mice and beating heart muscle cells, as well as 10 other mesodermal - derived cell lineages.

These days, mice grafted with human tumors, known as patient - derived xenograft (PDX) mice, are common in cancer research laboratories.

Using cell culture and laboratory mouse experiments, the researchers showed that the enzyme, aldose reductase, is essential to a process known as goblet cell metaplasia that is seen in both asthma and COPD.

Dr. Coyle's Laboratory for Psychiatric and Molecular Neuroscience takes advantage of insights into recently identified genes that confer risk for schizophrenia and related disorders and translates them into genetic mouse models to determine how these mutations affect brain changes as well as function, neurochemistry, and behavior.

His laboratory studies early mouse development as a model system to understand molecular mechanisms leading to establishment of pluripotency in vivo.

In 2012 she joined the laboratory of Dr. D.L. Konotyiannis at BSRC AL.Fleming, Greece as postdoctoral scientist, where she worked on the study of the RNA Binding Protein HuR during intestinal and lung inflammation and cancer, using inducible, KO and Tg mouse models and xenografts.

The successful candidate will leverage the extensive mouse - specific resources of The Jackson Laboratory in combination with classic mouse genetics, current ocular phenotyping and molecular biological techniques, and advanced technologies, such as CRISPR and single - cell RNA - Seq, to address his or her scientific questions.

- CNR has applied for and obtained the ethical and sanitary approval of the planned experimental activities with laboratory mice, including those to be carried out as part of the INFRAFRONTIER - project.

She now serves as the main surgeon of the laboratory, where she continues to perform brain surgeries on mice.

Laboratory mice have naturally longer telomeres than humans, which the researchers now think protect them from age - related genetic conditions, such as CAVD.

This breeding led to the creation of progenitors of modern laboratory mice as hybrids among M. m. domesticus, M. m. musculus and other subspecies.

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

Food and liquid intake measurements are recorded using patented algorithmic load cell technology as applied to behavioral research models of laboratory mice, rats and NHPs.

The dual appointment allows him to conduct experiments that compare genetic programming in the highly regenerative animals used as models at the MDI Biological Laboratory with genetic programming in neonatal and adult mice.

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.

C.C. Little, the inventor of the modern lab mouse and founder of the Jackson Laboratory, had long used «the age old enmity of woman and the Muridae» as a sales pitch for his model organism.

Meanwhile, the organisms themselves had begun to be packaged as commercial products: In 1941, the breeders at the Jackson Laboratory in Maine received a patent on their line of «JAX Mice» research animals; a year later, the Wistar Institute in Philadelphia trademarked its own line of «WISTARATs.»

Her laboratory also uses mouse models to study other neurogenetic diseases, such as schizophrenia and ALS, with a focus on genes that affect the course of disease and clinical outcomes.

The HZI will also provide access to laboratory and animal facilities up to BSL3 (including the gnotobiotic unit) and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

My laboratory studies the molecular mechanisms that govern mammalian development, using the mouse as a model.

They relate these results to those in laboratory animals, such as mice and rats, which offer a window on the pathways by which exercise can enhance brain health.

With rudimentary laboratories, one could argue that more was accomplished with regards to the effect of diet on cancer in the former half of the century, as revolutionary researchers like Tannenbaum, Rous, and their colleagues provided us with dozens of animal studies linking diet and cancer by exposing mice to free radical - laden vegetable oils.32, 33 Several decades later, two other researchers, Dayton and Pearce, provided one of the few studies revealing what happens when we give humans vegetable oils and their accompanying free radicals when they randomized men to a corn oil solution and a similar rise in cancer followed.34 It is no surprise that corn oil is often used in animal studies to cause cancer, as the ingestion of damaging free radicals predictably hastens cancer development.35 Furthermore, these scientists were the first to show that fasting, restricting calories, and cutting carbohydrates could lower the chance of cancer in animals exposed to dangerous chemicals and carcinogens.

For example, Tan & Counsilman (1985) have shown a strong correlation between early weaning and killing behavior in an experiment with laboratory mice as prey.