Sentences with phrase «as the tumor changes»

In addition to comparing existing therapies, the researchers will use their model to develop treatment plans that adapt as the tumor changes.

Not exact matches

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

«These changes are often referred to as tumor drivers but these are not the only deviations that impact cancer growth.

EM: Imaging such as MRIs or CT scans, which reveal the mass and volume of the tumor, can fool you sometimes: The patient gets a scan, goes on a therapy, and when they return in a month for a second imaging, the structure and size of the tumor haven't changed.

Global Cancer Facts and Figures, 2nd Edition, a report released in 2011 by The American Cancer Society, notes that cancers related to changing lifestyles as nations become wealthier, including lung, breast, and colorectal tumors, continue to rise in the developing world http://www.cancer.org/Research/CancerFactsFigures/GlobalCancerFactsFigures/global-facts-figures-2nd-ed

Until now, scientists have failed to establish a link between the properties of pancreatic cancer, such as its aggressiveness, and changes, i.e. mutations, in the tumor's genome.

Furthermore, the normal ductal cells that are able to develop into pancreatic cancer represent about 10 percent of the cells in the pancreas, complicating efforts to pinpoint the changes that occur as the tumor develops.

This same feature, tumor heterogeneity, may reduce the ability to identify critical gene expression changes when comparing mean gene expression in adjacent tumor and normal tissues, as tumors of the same type may have different sets of genes differentially expressed.

In skin tumors the process can start with a change in a single gene, such as H - ras.

The cell changes, known as an epithelial to mesenchymal transition, or EMT, are normal and helpful during wound healing, but problematic when cancer cells spread from the primary tumor site to other sites in the body.

Their recent study, which appears as the cover article in the May issue of Cancer Research, shows that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

Imaging assessments were difficult to interpret because potential treatment - related changes from the immunotherapy, such as inflammation, could not easily be distinguished from tumor progression.

This process requires a fundamental change in the character of cells within the primary tumor, insofar as members of a localized cell mass must be converted into actively migrating cells that invade into the surrounding tissue and blood vessels, and finally settle in distant tissues.

Patients» tumors may have various genetic changes; there can be different changes in different parts of the same tumor, as well as in different sites where the tumor spreads in the body.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

This allowed them to map a «family tree» of the changes happening at a genetic level as the disease spreads, forms new tumors, and becomes resistant to treatment.

The assembly and analysis of human tumor cell genomes, many of which contain chromosome deletions, duplications and insertions, as well as single nucleotide changes, requires immense data storage capacity and high - speed computation.

As we improve methods to identify epigenetic changes that occur during tumor development, can we develop approaches to discriminate between «driver» and «passenger» epigenetic events?

With TCGA, ICGC, and other datasets as a framework for comparison, we can undoubtedly learn a great deal about the somatic changes underlying rare tumor types.

To develop new drugs and determine what treatments are most appropriate for different tumor stages, scientists need to work out what changes occur at a molecular and genetic level as a tumor progresses.

Therefore the dosage of administration has to change at it has been previously observed with other treatment modalities such as; inhaled insulin.35, 37 A major obstacle regarding the distribution of aerosol within the airways is atelectasis, tumor mass or pleural effusion.

Right now, we don't have a method of detecting whether a tumor is reacting to medication until numerous cycles of therapy have been completed, but research by scientists at Brigham and Women's Hospital (BWH) could change that, with a new nanoparticle treatment providing the information in as little as eight hours.

They changed the way we think about many types of malignancy and provided new and effective ways to treat and prevent many hormone - driven tumors, a tradition that has expanded as the department has grown over the years.

Biocellion is being used to model a variety of biological system behaviors, such as biofilm formation and wrinkling, microbial growth dynamics in complex soil structure, brain tumor growth and invasion, formation of complex bacterial colonies, and changes in blood vessels and skin cells.

For example, the discovery of cancer - causing genetic and epigenetic changes in tumors has enabled the development of therapies that target these changes as well as diagnostic tests that identify patients who may benefit from these therapies.

«Instead of just monitoring changes in tumor size, we can watch the perfusion of a contrast agent as it moves toward, around and through a tumor,» Vannier said.

Using melanoma cells and both young and old normal skin cells as a model, the lab is trying to unravel what these changes may be, and how they affect tumor progression.

I had a hunch based on this work that microRNA expression would be different in breast cancer stem cells than in more differentiated tumor cells or normal tissue and that it would change as the stem cells differentiated to form a tumor.

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

Since heterogeneity in the tumor microenvironment, such as the presence of a neighboring blood vessel, may drive genetic changes, he reasoned that it might also be reflected on the level of proteins.

There's currently no method for detecting whether a tumor is reacting to medication until numerous cycles of therapy have been completed, but new research could change that, with a new nanoparticle treatment providing the information in as little as eight hours.

You may experience changes is in your bathroom habbits, pooping more or less often, as your body tries to adjust to the presence and demands of the tumor.

The doctor reading your mammogram will be looking for different types of breast changes, such as small white spots called calcifications, lumps or tumors called masses, and other suspicious areas that could be signs of cancer.

Diet - induced changes in tumor growth occur in parallel with changes in tumor biomarkers such as proliferation and apoptosis which are associated with improved clinical outcomes in humans.

Deafness may be caused by a number of factors, including congenital defects, chronic ear infections, head injuries, drug toxicity, degenerative nerve changes, old age or disease, such as a tumor or ruptured ear drum.

Ultrasound is useful in determining changes in organs, evaluating heart health, diagnosing pregnancy, as well as detecting the presence of cysts and tumors and other underlying symptoms of disease.

A careful balance exists where there are the same number of new cells are produced as there are dying off - and if this balance is disrupted, extra cells begin to replicate, undergo genetic changes, and it is these excess, mutated cells that gather together to form masses and tumors.

As pets reach the golden years, there are a variety of conditions and diseases that they can face, including weight and mobility changes; osteoarthritis; kidney, heart, and liver disease; tumors and cancers; hormone disorders such as diabetes and thyroid imbalance; and many otherAs pets reach the golden years, there are a variety of conditions and diseases that they can face, including weight and mobility changes; osteoarthritis; kidney, heart, and liver disease; tumors and cancers; hormone disorders such as diabetes and thyroid imbalance; and many otheras diabetes and thyroid imbalance; and many others.

In cats, brain inflammations (encephalitis), as yet unexplained degenerative changes in the cat's hippocampal portion of the brain (ref1, ref2), exposure to toxic substances, flea and tick control products, traumatic brain injuries, abnormal body metabolism, brain tumors and FIP account for most of the rest.

It may also help to identify concurrent problems such as bladder stones, changes in appearance of the liver or metastasis from an adrenal tumor.

As your dog reaches the golden years, there are a variety of conditions and diseases that they can face, including weight and mobility changes; osteoarthritis; kidney, heart, and liver disease; tumors and cancers; organ failure, hormone disorders such as diabetes and thyroid imbalance; and many otherAs your dog reaches the golden years, there are a variety of conditions and diseases that they can face, including weight and mobility changes; osteoarthritis; kidney, heart, and liver disease; tumors and cancers; organ failure, hormone disorders such as diabetes and thyroid imbalance; and many otheras diabetes and thyroid imbalance; and many others.

Use grooming sessions as a means of checking for tumors, growths, or changes in skin condition.

For example, a sign of a brain tumor may be a slower walk or a change in gait, both of which could be attributed to general aging as well.

I provide cognitive rehabilitation interventions for individuals coping with neurological and neuropsychological conditions such as age - related memory changes, tumor, epilepsy, brain injury, stroke, ADHD, learning disability, and neurotoxic infections.