Sentences with phrase «as therapeutic targets»

The new enzymes could serve as therapeutic targets for drug developers.

Researchers identified a single enzyme doing the work of a trio thought necessary to control a common cellular signaling process being pursued as a therapeutic target.

Furthermore, results may encourage other research groups to use the M2 channel of influenza virus as therapeutic target against the influenza A virus.

My laboratory aims to identify, characterize and validate lncRNA - driven pathways active in allergy - driving helper T cells and airway epithelial cells that could hold promise as therapeutic targets in altering the aberrant immune responses underlying asthma.

Crucial in the checkpoint process are co-simulatory and co-inhibitory molecules, proteins that show remarkable promise as therapeutic targets for cancer.

My Honours project focused on genetically validating the Signal Transducer and Activator of Transcription 3 (STAT3) protein as a therapeutic target by using a novel transgenetic mouse model in which a short hairpin RNA directed against STAT3 can reversibly be induced by the administration of doxycycline.

Generating mouse models to validate telomeres and telomerase as therapeutic targets for cancer and age - related diseases.

He is currently pursuing the possibility to use circulating microRNAs as biomarkers as well as therapeutic targets for neurodegenerative diseases including Alzheimer's disease (AD).

Cancer research in the era of genome medicine necessitates an in - depth understanding of protein functions before they can be explored as therapeutic targets or diagnostic candidates.

Early - phase data on larotrectinib validate TRK fusions as therapeutic targets and show they lead to tumor - agnostic sensitivity to this agent.

Speaker, H. Alex Brown, «Mass Spectrometry - Based Metabolomics: Phosphatidic Acid Pathways as Therapeutic Targets for Cancer and Infectious Disease».

Research from Rutgers Cancer Institute of New Jersey shows that the RUNX2 protein, which regulates the transcription of genetic messages responsible for the different functions of cells, may play a role in melanoma cell growth and spread and could serve as a therapeutic target for the disease.

SMYD2 could therefore be used as a therapeutic target in the shock and kill strategy.»

«CRMP1 was not regarded as a therapeutic target so far, now it is worth exploring as a potential target,» said Wanker.

We hope that with more samples from patients, we'll be able to link more genetic regions to the disease, and it will become easier to identify underlying pathways that could act as therapeutic targets.»

Altered sphingolipid levels in blood have been associated with depression and have been proposed as a therapeutic target for major depressive disorder.

This discovery also opens the door to using the TNF receptor as a therapeutic target.

It raises the possibility that oxytocin could be considered as a therapeutic target across a variety of psychiatric disorders.»

Most importantly for individuals with FOP, the study identifies HIF - 1α as a therapeutic target — knowledge that will likely contribute to the development of more effective treatments for FOP and related common disorders of heterotopic ossification.

«We've identified the enzyme JNK3 as a therapeutic target to treat the symptoms of spinal muscular atrophy,» says Laxman Gangwani, Ph.D., an associate professor in the Center of Emphasis in Neuroscience at Texas Tech University Health Sciences Center El Paso (TTUHSC El Paso) who led the research.

In a previous study, Sredni and colleagues were the first to describe PLK4 as a therapeutic target for brain tumors and in pediatric cancer.

Members of the steroid receptor coactivator (SRC) family of oncogenes are especially promising as therapeutic targets because these proteins sit at the nexus of key signaling pathways that cancer cells use to quickly grow, spread to other tissues, and acquire drug resistance.

The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis

These findings highlight the potential of Nav1.1 and inhibitory interneurons as a therapeutic target in AD and that disease - specific molecular optimization of cell transplants may be required to ensure therapeutic benefits in different conditions.

Wen J, Zhang JQ, Huang W, Wang Y. SDF - 1alpha and CXCR4 as therapeutic targets in cardiovascular disease.

The work provides insights into the future use of TNFR2 as a therapeutic target.

Modulating ECM assembly to alter tumor vascular barrier function Weilan Ye, Genentech Lymphangiogenesis and lymphatic endothelial barrier as targets in regenerative medicine Giorgia Jurisic, Novartis Wnt / beta - catenin signaling as a therapeutic target for blood - brain barrier repair in neurological disorders Dritan Agalliu, Columbia University Somatic mutations in hematopoietic cells contribute to cardiovascular disease: New mechanisms, new targets Kenneth Walsh, Boston University

4 - 1BB as a therapeutic target for human disease.

KIT as a therapeutic target in metastatic melanoma.

This goes back to needing better training for mental health professionals so that primary care providers can easily refer their patients to competent therapists in the community who will directly address pain as a therapeutic target.

Since many human cancers are driven by mutations increasing tyrosine kinase activity, these proteins and the molecules they interact with have come center stage as therapeutic targets.

Luo and Qiu lead a research team that identified an enzyme that could independently accomplish ubiquitination, an important cellular signaling process being pursued as a therapeutic target.

Szmydynger - Chodobska said the team is also interested in looking at the proteins as therapeutic targets.

«Our findings have implications for how to think about the earliest processes that drive cancer and telomerase as a therapeutic target.

The researchers conclude that the beta - amyloid dimers are covalently linked in the brains of subjects with AD and that therefore they emerge as potential biomarkers of the disease, as well as therapeutic targets.

Sigma 1 has long been explored as a therapeutic target, but even after years of study, researchers still aren't sure exactly how it influences other proteins and pathways.

«Our data not only validate TRK fusions as therapeutic targets but also show that they lead to tumor - agnostic sensitivity to larotrectinib,» the authors wrote.

The team is now validating the pathway as a therapeutic target to prevent type 2 diabetes.

Our goal is to identify signaling pathways which control or coordinate these different phenotypic transitions and to evaluate how these pathways can be influenced by the cellular environment, altered in pathological contexts or serve as therapeutic targets.

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

The pathologist of the Department of Pathology at the University Hospital of Bellvitge August Vidal explained that «this tumorigenic transformation depends on Dicer protein that could serve as a marker for the presence of tumor cells, or as a therapeutic target.»

The study points to neural plasticity, whereby the brain essentially «re-wires» connections between neurons to reestablish control pathways, as a therapeutic target for the recovery of fine motor control and grasping ability.

The researchers also will study which alterations should be developed as diagnostic and prognostic biomarkers or as therapeutic targets that may offer hope to patients with ALS.

«We began to mine the data to look for metabolites that might serve as biomarkers or as therapeutic targets,» Chinnaiyan explained.

5) Saurabh K, Scherzer MT, Shah PP, Mims AS, Lockwood WW, Kraft AS, Beverly LJ (2014) The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.

, Kraft AS, Beverly LJ (2014) The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.