Sentences with phrase «as transcription factor binding»

ALFA compiles the current state - of - art about the annotations of DNA regulatory elements (such as transcription factor binding sites, microRNA target sites) for a better understanding of biological processes underlying rare diseases.

Not exact matches

The gene encodes a transcription factor, a protein that in this case binds to DNA and allows it to be read out as messenger RNA.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

In addition, the total amount of a protein can be regulated by alternative splicing, which is illustrated in the current work by using the general transcription factor TBP (TATA - box binding protein) as an example.

Unlike most proteins, those with these special domains can actually bind to DNA and act as transcription factors — telling specific genes to turn on or off.

The genes for each transcription factor were made from different bits of DNA that code for the functional parts of proteins, such as a domain that can bind to DNA and another that provides the protein with access to the cell's nucleus.

MYCN and its kin are «transcription factors,» proteins that bind to DNA and influence the rate at which genetic information is used by the cell — essentially serving as brightener / dimmer switches for gene activity.

Since its development, lattice light - sheet microscopy has been used to image numerous important events, such as single transcription factor molecules binding to DNA, hotspots of transcription, microtubule instability, protein distributions in embryos, and much more.

These include methods for deconvolution in fluorescence microscopy as applied to cellular morphogenesis, in addition to methods for live - cell binding measurements using fluorescence recovery after photobleaching (FRAP), fluorescence correlation spectroscopy (FCS) and single molecule tracking (SMT) as applied to transcription factor regulation.

A successful candidate should have the following qualifications: a Ph.D. in the field of Molecular Biology, Cell Biology, Biochemistry or related field; an established track - record of publications in peer - reviewed journals; solid experience in the biochemistry of complex DNA - binding proteins (such as chromatin remodeling factors or DNA repair proteins), their purification from heterologous expression systems as well as their characterization using functional studies such as by isothermal titration calorimetry fluorescence, transcription assays.

(A) Venn diagram depicting the overlap between transcription factors bound by H3K4me3 ChIP - seq in the combination group, as compared to the chidamide (CHID)- treated group and the decitabine (DECI)- treated group in KMT2D V5486 - mutated Jurkat cells.

In eukaryotes, a homeobox encodes a protein domain (the homeodomain) which can bind DNA that act as part of transcription factors to switch on cascades of other genes that induce cellular differentiation by initiating the cascades of coregulated genes required to make individual tissues, organs, or body parts.

ChIP - Seq is a powerful tool to study genetic regulation, because it enables one to accurately identify regions of DNA bound by specific proteins, such as transcription factors or RNA Polymerase II components.

Besides, some other potential cis - acting elements for transcription factors [such as CAAT / enhancer binding protein (C / EBP) and PU.1] have been also noted in the RIG - G gene promoter.

A group of transcription factors bind to other parts of p300 (not shown) in an assembly known as an enhanceosome.

As a transcription factor, STAT6 usually recognizes a consensus - binding site (TTCTGTTGAA) to induce the transcription of the responding gene.

Because STAT2 is the only member of the STAT family without DNA - binding activity, it can act as a transcription factor only when complexed to other STATs or proteins (31).

For example, our studies identified transcription factors, RNA binding proteins, and signaling genes as critical miRNA targets during contexts such as development of peripheral sensory organs, wing, eye, and CNS, or during behavioral contexts such as egg - laying, rhythmic behavior, and locomotor activity (Figure 2).

As the target sequences for transcription factors are short, and transcription factors are tolerant of considerable variation in the sequences to which they bind, it is extremely difficult to distinguish functional binding sites in the vastness of the human genome.

As for myself, I will pick up articles in prebiotic chemistry, virology as it relates to retroviruses or bacterial viruses, or molecular biology, such as those dealing with new discoveries related to promoters, transcription factors (proteins and RNAs which regulate the expression of other proteins and RNAs by binding to promoters), but even after having read a fair amount, trying to fit together pieces in a puzzle, I will be lucky if I have actually understood more than half of a given article at a relatively basic leveAs for myself, I will pick up articles in prebiotic chemistry, virology as it relates to retroviruses or bacterial viruses, or molecular biology, such as those dealing with new discoveries related to promoters, transcription factors (proteins and RNAs which regulate the expression of other proteins and RNAs by binding to promoters), but even after having read a fair amount, trying to fit together pieces in a puzzle, I will be lucky if I have actually understood more than half of a given article at a relatively basic leveas it relates to retroviruses or bacterial viruses, or molecular biology, such as those dealing with new discoveries related to promoters, transcription factors (proteins and RNAs which regulate the expression of other proteins and RNAs by binding to promoters), but even after having read a fair amount, trying to fit together pieces in a puzzle, I will be lucky if I have actually understood more than half of a given article at a relatively basic leveas those dealing with new discoveries related to promoters, transcription factors (proteins and RNAs which regulate the expression of other proteins and RNAs by binding to promoters), but even after having read a fair amount, trying to fit together pieces in a puzzle, I will be lucky if I have actually understood more than half of a given article at a relatively basic level.