Sentences with phrase «as tumor control»

Therefore, it is critical that the initial treatment be focused on pain control as well as tumor control.

Not exact matches

But none of the control rats developed brain tumors as would have been expected, and the male rats exposed to radiation actually outlived their non-exposed counterparts.

For instance, most common adult solid tumors that are not cured by surgical removal are resistant to chemotherapy or radiation control, yet drug therapy is frequently offered as a «possibly effective» treatment because both patient and physician want to believe it so.

Two other reports in the same issue of Cancer Causes and Control suggest that children born to mothers who eat at least one hot dog per week during pregnancy have double the normal risk of developing brain tumors, as do children whose fathers ate hot dogs before conception.

When Markovic told his wife, a cardiologist, about his discovery of the striking similarities between how tumors and placentas control the immune system, he describes her as being wholly unsurprised.

Seven to eight weeks after the tumor was established, each mouse received one intravenous injection of GD2 CAR - T cells or, as a control treatment, an injection of CAR - T cells that react to a different target.

The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.

Children progressively lose muscle control as the tumor rapidly attacks the pons, a region deep inside the brain that connects the brain to the spinal cord, and is difficult to reach and surgically remove.

One adaptation to this fortunate reality is that rather than using overall survival (OS) as the measure of a drug's success, many clinical trials now use a kind of midpoint, namely progression - free survival (PFS)-- the time that it takes for a tumor controlled by the trial's medicine to restart its growth.

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

Joining forces with dermatologists and oncologists from the University Hospital in Zurich and backed by the University Research Priority Program «Translational Cancer Research,» Sommer's team was able to demonstrate that, in melanoma cells, the epigenetic factor EZH2 controls genes that govern tumor growth as well as genes that are important for the formation of metastases.

An inactive rhomboid protease, iRhom2, is normally a short - lived protein that controls a cascade of events involved in wound healing as well as tumor growth.

The National Institutes of Health today announced in Nature that it has reached an understanding with the family of the late Henrietta Lacks to allow biomedical researchers controlled access to the whole genome data of cells derived from her tumor, commonly known as HeLa cells.

Mice injected with breast cancer cells making lots of a long strand of RNA called HOTAIR developed 10 times as many lung tumors as controls (left) did.

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

SBRT appeared to improve tumor control, as suggested by the initial study results for RTOG 0236.

CHICAGO, Ill. — The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.

More importantly, Zhang and his team for the first time found that treating the pancreatic tumor cells with MIR506 induced autophagy, a process that occurs as a normal and controlled part of an organism's growth or development and that could promote cancer cell death.

Specifically, TheraT ® has proven to be safe in animals as well as capable of eliciting uniquely potent antigen - specific CD8 + cytotoxic T cell responses and strong tumor control in mice.

We further determined that T cells deficient in DGKζ exhibit greater control of murine pancreatic tumor growth as compared with T cells deficient in Cbl - b.

As an assistant professor at the Boston University Medical School, she became interested in the control of cellular senescence and its role in tumor suppression and aging.

LKB1, originally identified as a tumor suppressor protein, is currently thought as a critical regulator of cellular metabolism and growth by controlling the activity of AMP - activated protein kinase (AMPK) and also 12 other kinases that are closely related to AMPK.

Instead of talking about cures and remission, doctors are now talking about cancer as being more of a controlled equilibrium with a tumor, in which it does not grow or cause issues.

As a result, cell growth gets out of control, leading to tumors.

Results published by the Altieri laboratory demonstrated that these molecules accumulate in mitochondria of tumor cells, where they physically interact with components of the organelle permeability transition as well as with a number of regulators of bioenergetics, including the control of protein production, lipid metabolism and ATP generation.

In all negative tumors, occasional positive tumor cells or coexisting reactive lymphocytes were present and served as internal positive controls (arrows in C, right).

The laboratory currently pursues four integrated research objectives: 1) Defining how dynamic regulation of adhesion and migration controls metastasis, 2) Identification and characterization of the metastatic cell populations within a primary tumor, 3) Experimental modeling of metastasis in a clinically relevant manner, and 4) clinical implementation of molecular markers of migration as biomarkers of tumor progression and metastasis.

And in view of PTEN's critical role as a tumor suppressor, it's also important that the process we uncovered is a controlled one, not random as was previously believed.»

For each of the 10 somatic mutations, as well as 2 germline control variants, we performed PCR - targeted 454 resequencing in samples from the primary tumor, the relapse tumor, and the germline.

As part of the Cancer Genome Atlas Project (TCGA), we've been applying both targeted (capture - based) and whole - genome sequencing approaches to tumor samples and matched normal controls.

Programs are clustered into Discipline - Based or Disease - Oriented and bring together investigators from all research disciplines (basic, population focused, and clinical) to tackle the challenges of tumor development and progression, diagnosis and treatment, as well as cancer control and disparities.

In essence, Knudson, far ahead of his time (and ahead of his own hard data) hypothesized that some genes» normal role in life is to behave as anticancer or tumor - suppressor genes that keep cell division under healthy control.

Various conditions and medications can lead to secondary hypertension, including: Kidney problems; Adrenal gland tumors; Thyroid problems; Certain defects in blood vessels you're born with (congenital); Certain medications, such as birth control pills, cold remedies, decongestants, over-the-counter pain relievers and some prescription drugs; Illegal drugs, such as cocaine and amphetamines; Alcohol abuse or chronic alcohol use; Obstructive sleep apnea.

They found that tumor growth was suppressed more than 50 percent as compared to the control mice without the shot.

Brain disease, such as a tumor or stroke, that damages the auditory nerve or other parts of the central nervous system that control hearing can also affect hearing.

Along with birth control, behavioral correction, and removal of sexual frustration, various kinds of reproductive tract problems such as ovarian and uterine tumors, mammary gland tumors and cervical tumors can be prevented with feline spaying.

Successful treatment includes control of the primary tumor as well as prevention of metastasis.

The simplicity of the treatment and the fact that it is so natural is what attracts many people to staples of natural Chinese medicine such as Yunnan baiyao, which can also be used to help control bleeding from cancerous tumors in dogs.

The mutations may be in genes governing some aspect of the immune system but they might also be in tumor suppressor genes whose job it is to seek out and destroy cancerous cells, genes that control cell division, genes that control normal cell death, and other types as well.

It has also been shown to help control the expression of certain proteins that are related to a cancerous process, such as modulating the expression of proteins 5 - LOX, TNF (tumor necrosis factor), NF - kappa B, COX - 2 and others.

In cats, brain inflammations (encephalitis), as yet unexplained degenerative changes in the cat's hippocampal portion of the brain (ref1, ref2), exposure to toxic substances, flea and tick control products, traumatic brain injuries, abnormal body metabolism, brain tumors and FIP account for most of the rest.

This can be a hormone imbalance such as an overly active adrenal gland, diabetes, liver or kidney failure, an immunosuppressive tumor or the use of medications that suppress your pet's ability to keep mite numbers under control.

The Cambridge - educated writer was diagnosed with a rare brain tumor two years ago and continued to work virtually throughout his illness, submitting articles even as he incrementally lost control over his speech.

«The genotoxicity of mainstream smoke carcinogens manifests as mutations occurring in key cancer - related genes, i.e., proto - oncogenes or tumor suppressor genes that control crucial cellular functions, e.g., growth and survival, in lung tumors of active smokers.»