Sentences with phrase «as tumor suppressor genes»

After the KRAS mutation was induced by the researchers, other mutations in what are known as tumor suppressor genes developed.

These findings show that MAX acts as a tumor suppressor gene in one of the more aggressive types of lung cancer.

Thus, our results demonstrate that Rassf1A acts as a tumor suppressor gene.

Not exact matches

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

Correspondingly, a large number of genes with no direct role in tumor progression also are deleted as a result of their proximity to tumor suppressor genes.

A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.

«It wasn't known whether miR - 486 functioned as an oncogene or a tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.

But it's much harder to develop therapies that restore malfunctioning genes that should be triggering cell death in abnormal cells, known as tumor - suppressor genes.

BRCA1 and 2, genes whose proteins are supposed to work as tumor suppressors and also repair DNA damage, were the first known risk factor genes for familial breast cancer as well as ovarian and other cancers.

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus - like eremophytes instead of normal plants from the drought).

Center for Elephant Conservation, elephants have 38 additional modified copies (alleles) of a gene that encodes p53, a well - defined tumor suppressor, as compared to humans, who have only two.

Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.

This phenomenon could result in breakage in the human genome, and when a breakage impacts important genes, such as tumor suppressors, it could lead to cancer development.

Or stem cells injected into a patient as therapy might be designed so that their tumor suppressor genes are less likely to mutate and cause cancer.

In humans, cancer develops when genes that suppress cancer, known as tumor suppressors, are lost and when mutations or genes that promote cancer, known as oncogenes, are gained or activated.

But the idea fell out of fashion as researchers began to discover that mutations in specific oncogenes and tumor - suppressor genes could set cancer in motion.

Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in BRCA1 / 2 - mutated tumors.

In breast cancer, miR - 21, 155, 27, 96, 182, and 128 were identified as oncogenes, whereas miR - 125, 205, 27, 17, 206, and 145 were found to be tumor suppressor genes, and their corresponding target genes were also defined (10 — 12).

As a powerful tumor suppressor, p53 turns on genes that either halt cell division to allow time for repair of damaged DNA or, when all rescue attempts prove futile, to prevent cells with genetic defects from dividing, as this would fuel the development of canceAs a powerful tumor suppressor, p53 turns on genes that either halt cell division to allow time for repair of damaged DNA or, when all rescue attempts prove futile, to prevent cells with genetic defects from dividing, as this would fuel the development of canceas this would fuel the development of cancer.

In back - to - back papers published online July 28 in Science, researchers from the Broad Institute, Dana - Farber Cancer Institute, Johns Hopkins Kimmel Cancer Center, the University of Pittsburgh, and the University of Texas MD Anderson Cancer Center have confirmed genetic abnormalities previously suspected in head and neck cancer, including defects in the tumor suppressor gene known as p53.

Phosphatase and tensin homolog (PTEN): Adding an extra copy of the tumor suppressor gene PTEN to mice produces lower rates of cancer, much as expected, but also increased life span.

MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype - associated genes in medulloblastoma.

Thirteen tumors had two non-silent MAP3K1 mutations (biallelic loss), and most of the mutations are highly deleterious (nonsense, frameshift, etc.) suggesting that this gene may act as a tumor suppressor.

Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.

People who have a tumor suppressor gene known as Sprouty2 may have a higher risk of some colorectal cancers.

In conclusion, our study characterizes the biological function of DDX3 as a putative candidate tumor suppressor gene, at least in HCC and cutaneous SCC.

Cancer can also occur when certain normal genes (tumor suppressor genes, for example) are «switched on or off» as a result of environmental epigenetics — influences that occur throughout your life.

During his 11 years of extensive work experience in the fields of cell and cancer biology (including work on the famous tumor suppressor gene BRCA1), and biochemistry he has successfully published in peer - reviewed journals such as Molecular and Cell Biology and Cancer Research.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Mutations in the NF1 gene cause defects in the neurofibromin 1 protein, which acts as a tumor suppressor.

The intronic microRNA (miR)-342 has been proposed as a potent tumor - suppressor gene.

We validated ZBTB20, CELF2, PARD3, AKAP13 and WAC, which were identified by our screens in multiple cancer types, as new tumor suppressor genes in prostate cancer.

But a puzzle remains: if a drug wipes away methylation indiscriminately, that might turn on an oncogene just as much as it might restore a tumor suppressor gene.

Genetic mutations that alter tumor suppressors such as the p53 gene are known to help tumors grow, and epigenetic modifications, too, can deactivate genes like this one.

BRCA genes belong to a class known as tumor suppressors, according to the National Cancer Institute (NCI).

In essence, Knudson, far ahead of his time (and ahead of his own hard data) hypothesized that some genes» normal role in life is to behave as anticancer or tumor - suppressor genes that keep cell division under healthy control.

«Progestins are not the same as progesterone and do not provide the vital intracellular message that stimulates tumor - suppressor genes that fight cancer...»

The mutations may be in genes governing some aspect of the immune system but they might also be in tumor suppressor genes whose job it is to seek out and destroy cancerous cells, genes that control cell division, genes that control normal cell death, and other types as well.

«The genotoxicity of mainstream smoke carcinogens manifests as mutations occurring in key cancer - related genes, i.e., proto - oncogenes or tumor suppressor genes that control crucial cellular functions, e.g., growth and survival, in lung tumors of active smokers.»