Sentences with phrase «as tumors develop»

CHICAGO — The protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop.

The protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop.

However, not everyone's melanoma will benefit equally from MAPK - targeted therapies, and initial benefits might wane over time as tumors develop resistance to treatment.

Furthermore, the normal ductal cells that are able to develop into pancreatic cancer represent about 10 percent of the cells in the pancreas, complicating efforts to pinpoint the changes that occur as the tumor develops.

As the tumor develops, the affected area becomes more painful, and swelling becomes noticeable, resulting in a limp that escalates quickly from intermittent to constant.

Not exact matches

But none of the control rats developed brain tumors as would have been expected, and the male rats exposed to radiation actually outlived their non-exposed counterparts.

Two other reports in the same issue of Cancer Causes and Control suggest that children born to mothers who eat at least one hot dog per week during pregnancy have double the normal risk of developing brain tumors, as do children whose fathers ate hot dogs before conception.

The ability for cancer cells to develop resistance to chemotherapy drugs — known as multi-drug resistance — remains a leading cause for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists could one day direct cancer cells to «turn off» their resistance capabilities.

In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.

«This finding,» Villanueva said «opens the door to developing new biomarkers and new therapeutic strategies exploiting these characteristics of exosomes in breast tumors, and other tumors such as ovarian and endometrial cancer among others.»

In some horses, tumors develop as small bumps under the skin or as scaly lesions that easily can be removed by a veterinarian, but in other horses the problem becomes much more serious.

Tumor biopsy is often impossible for early cancer diagnosis as the developing tumor is too small to see by the current imaging tTumor biopsy is often impossible for early cancer diagnosis as the developing tumor is too small to see by the current imaging ttumor is too small to see by the current imaging tools.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

But as noted in a recent Science news story, targeted therapies don't work as well on solid tumors, which usually develop resistance and start growing again.

These details tell researchers about the heterogeneity of tumors, which is essential for developing appropriate research and drug protocols that can navigate all the inherent complexity of not just the anatomy and physiology being imaged but also how imaging technologies intersect to capture as much information as possible.

But it's much harder to develop therapies that restore malfunctioning genes that should be triggering cell death in abnormal cells, known as tumor - suppressor genes.

The first long - term study of a pioneering endoscopic laser treatment for early vocal - cord cancer, developed at Massachusetts General Hospital (MGH) and previously shown to provide optimal voice outcomes, finds that it is as successful as traditional approaches in curing patients» tumors while avoiding the damage to vocal quality caused by radiotherapy or by conventional laser or cold - instrument surgery.

As tumors grow and develop, they shed micro-metastases, clusters of a few cells that take up residence in far - flung organs such as the brain, liver and bonAs tumors grow and develop, they shed micro-metastases, clusters of a few cells that take up residence in far - flung organs such as the brain, liver and bonas the brain, liver and bone.

Global Cancer Facts and Figures, 2nd Edition, a report released in 2011 by The American Cancer Society, notes that cancers related to changing lifestyles as nations become wealthier, including lung, breast, and colorectal tumors, continue to rise in the developing world http://www.cancer.org/Research/CancerFactsFigures/GlobalCancerFactsFigures/global-facts-figures-2nd-ed

Researchers developed models to examine the influence of driver mutations — mutations that promote cancer development — on the initiation and development of gliomas, and how tumor genomic profiles evolve as the cancer progresses.

Rather than artificially triggering cancer by engineering genetic mutations, this model more closely mimics human liver cancer in that tumors develop as a natural consequence of non-alcoholic steatohepatitis (NASH), a chronic metabolic disorder that causes liver damage, fibrosis and numerous cell mutations.

Over the past two years Skinner, of Washington State University, showed that as male descendants of these rats aged, they developed sperm deficiencies, infertility, and various other afflictions, from breast tumors to kidney disease.

AFP reports that Israeli researchers found that frequent cell phone users — described as people who chatter on mobiles more than 22 hours a month — had a nearly 50 percent higher risk than others of developing a tumor on the parotid gland (the largest of the salivary glands on the side of the face just in front of the ear).

After the KRAS mutation was induced by the researchers, other mutations in what are known as tumor suppressor genes developed.

In some cases such as ovarian cancer, however, drug - free intervals are needed to allow patient recovery from side effects, during which tumors can sometimes begin to grow again or develop resistance to the drugs being used.

Kwak has developed anti-cancer therapeutic vaccines to spark an immune system attack against tumors, but their effectiveness has been hindered by factors such as MDSCs that stifle immune response.

Rather than simply identifying a cancer by location or tissue type, researchers now use advanced molecular profiling tests to characterize tumors, the proteins they express and the novel mutations they develop — known as neoantigens.

Tumor necrosis factor inhibitor drugs (commonly called Anti-TNFs) modestly reduce the risk of acute coronary syndrome, such as heart attacks and angina, in rheumatoid arthritis patients whose inflammation places them at higher risk of developing coronary heart disease, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in San Diego.

A better approach, Monje said, would be to develop drugs that specifically block the tumor - stimulating activities of neuroligin - 3, such as a drug that stops the protein from being secreted into the area around the cancer cells.

Sanford Research scientists are published in Nature Cell Biology for their work developing a model to explore therapies for a pediatric brain tumor known as choroid plexus carcinoma.

Because diseases such as cancer tend to evade detection by T - cells» receptors, allowing a tumor to grow unchecked, scientists have long sought «intel» on this process as a means of developing therapies that target malignant cells, but leave healthy cells alone.

The memory and thinking problems experienced by cancer survivors, known as «chemo brain» or «chemo fog,» are not just the result of chemotherapy treatment, they may start as tumors form and develop, suggests a Baycrest - led study.

This causes genomic instability in developing immune cells and, in the absence of a working tumor suppressor protein such as p53, an aggressive form of lymphoma develops in mice.

Mice injected with breast cancer cells making lots of a long strand of RNA called HOTAIR developed 10 times as many lung tumors as controls (left) did.

The researchers also found that lymph node metastases appear to have developed from several different tumor cells that lodged in the nodes, not from a single tumor cell as is the case with many but not all distant metastases.

Their latest pledge came after Druker recently lobbied the couple for another $ 1 billion to take insights from Gleevec, as well as other so - called molecularly targeted therapies, and develop better early detection tools for tumors.

In humans, cancer develops when genes that suppress cancer, known as tumor suppressors, are lost and when mutations or genes that promote cancer, known as oncogenes, are gained or activated.

This work shows that the tumor microenvironment itself can compromise the efficacy of targeted therapies and should be taken into account as new treatment approaches are developed.»

Offspring that inherited the triplicated genes and the genetic susceptibility to cancer had only half the number of intestinal tumors as their cancer - prone parents, and the tumors that did develop were smaller, the team reports in the 3 January issue of Nature.

«Because the tumors develop spontaneously, there is heterogeneity in that tumor population, as a human being would have.

a. Do not use MMTV - PyMT female mice for breeding as they develop mammary tumors.

Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in BRCA1 / 2 - mutated tumors.

As we improve methods to identify epigenetic changes that occur during tumor development, can we develop approaches to discriminate between «driver» and «passenger» epigenetic events?

FRY could potentially be used as a platform to develop cancer gene - based susceptibility tests, for disease progression and for tumor grading.

Finally, Dr. Goldenring's laboratory is also investigating the role of Rab25 as a tumor suppressor in the colon using the Rab25 - / -; Smad3 + / - mouse model, which develops spontaneous invasive distal colon cancers.

In the end, many oncologists believe that PDX mice are a powerful means to an end — achieving successful, individualized treatment plans for cancer patients based on the genetic makeup of their tumor — but not the end itself, as developing PDX mice for every cancer patient is simply not practical.

To find out, Einstein's George Karagiannis spent nearly three years experimenting with lab mice whose genetic mutations make them spontaneously develop breast cancer, as well as mice given human breast tumors.

NCI's efforts to develop new laboratory models of human cancer includes vastly increasing the number of human cancer cell lines (grown as two - dimensional and three - dimensional cultures) and patient - derived tumor xenografts.

To develop new drugs and determine what treatments are most appropriate for different tumor stages, scientists need to work out what changes occur at a molecular and genetic level as a tumor progresses.

Using her mouse model, Stromnes watched as pancreatic tumors developed and noticed that one type of regulatory immune cell stood out.