Not exact matches
In humans, there are about 100 proteins associated with
ubiquitination, the process by which a protein labelled with ubiquitin is removed from the cell by specific cell machinery known
as the proteosome.
Luo and Qiu lead a research team that identified an enzyme that could independently accomplish
ubiquitination, an important cellular signaling process being pursued
as a therapeutic target.
The team found another unique aspect of the
ubiquitination process is the use of a molecule named nicotinamide adenine dinucleotide, or NAD,
as a source of energy.
The latter is responsible for wasting of skeletal muscle
as the innate proteasomes destroy specific proteins through the process of
ubiquitination.