Treatment can involve dietary changes — including reduced protein intake and alcohol consumption — anti-inflammatory and pain - relieving drugs, as well
as urate - lowering medications.
Gao said the idea is exciting,
as urate levels can be raised easily and inexpensively, but it must also be done cautiously, as excessively high levels of urate can cause kidney stones and gout.
Not exact matches
Inosine is naturally converted by the body into
urate as part of normal metabolism, whereas
urate taken orally would be broken down in the digestive system.
«We know that
urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use
as a disease - modifying strategy in Parkinson's; so the positive results of this trial are very encouraging.»
A reduction in animal protein reduces the production of acids within the body and appears to limit the excretion of
urate — uric acid crystals that can act
as seeds to form calcium stones or create entire stones themselves.
A reduction in animal protein should also limit the excretion of
urate — uric acid crystals that can act
as a seed to form calcium stones, or can create entire stones themselves.
Uroliths are composed of crystallized minerals, such
as struvite, oxalate,
urate, or cystine.
Urate calculi tend to be small and occur
as several stones.
Common statistics of
urate stone formation in Dalmatians
as reported by Veterinary Information Network:
Given that kidney issues are not seen
as a primary breed health concern nor do people realize that some kidney disease (RD and
urate stones) are inherited this number may be understated.
The hyperuricosuria is not the only cause of
urate urolithiasis, and conditions such
as portosystemic shunts and hepatic microvascular dysplasia also may predispose dogs to this disease.
Ammonium
urate crystals and stones also rose
as dietary pH dropped; they are rare when the urine pH is greater than 6.6 and the SG is less than 1.030.
Uroliths are composed of crystallized minerals, such
as struvite, oxalate,
urate, cystine, or calcium phosphate.
Dalmatians are in a class by themselves,
as as hereditary disorder often produces
urate crystals and stones in the breed.