Not exact matches
Today all new viral
strains used to make
vaccines must be generated by specific artificial genetic modifications rather than by «breeding,» so
as to prevent possible reversion back to a virulent form.
«Even when the
vaccine is not a perfect match to the circulating influenza
strain,
as is the case this year, the
vaccine still helps prevent more severe infections if children get sick with the flu,» she says.
«The original
strain used
as a reference for the
vaccine was basically a perfect match to the dominant circulating
strain, and the predicted efficacy would have been around 47 percent.
Dr Derek Gatherer of Lancaster University said: «Every year we have a round of flu vaccination, where we choose a recent
strain of flu
as the
vaccine, hoping that it will protect against next year's
strains.
As new disease
strains continue to develop, and globalization and travel make it easier to pass disease across geographical borders, the ability to whip up huge quantities of effective
vaccine is becoming increasingly important.
Scientists contacted by Nature say that basic research on such mutated
strains may eventually yield insight relevant to developing pandemic countermeasures such
as drugs and
vaccines.
Findings from this study of flu
vaccines delivered by a small needle intradermally parallel earlier results that found adding a
strain of influenza B could improve the effectiveness of a flu
vaccine nasal spray and a traditional intramuscular
vaccine that is injected
as a shot in the arm muscle.
The responses of those given the quadrivalent
vaccine were the same
as those of volunteers who received the
vaccine with two
strains of A and the
strain of B that matched the B
strain in the 2012 - 2013 seasonal flu trivalent
vaccine.
They are also angry that the
vaccine is based on the original
strain of HIV, known
as IIIB, which is unlike the
strains prevalent in Thailand.
The
vaccine was targeted especially toward the virus
strain circulating in Thailand, and it may not show the same effectiveness where the virus is different, such
as Africa or the U.S. And even the 31.2 percent fewer cases that it resulted in is hardly an ideal preventative strategy.
The
vaccines targeted an influenza A H1N1 seasonal flu
strain as well
as A (H7N9), a virus considered to have the potential to trigger a human pandemic.
Flu
vaccine production is always a bit of a gamble, and, unfortunately, the
strain the researchers had chosen
as a target wasn't the most virulent one roaming the U.S. that year.
Vaccination with the pneumococcal conjugate
vaccine - 7 [PCV7 — a
vaccine that covers 7
strains (serotypes) of Streptococcus pneumoniae] is linked to overall decreases in the rate of serious infections caused by this bacterium, such
as pneumonia and meningitis, referred to
as invasive pneumococcal disease (IPD)-RSB-, but small increases in IPD caused by serotypes of Streptococcus pneumoniae not covered by the
vaccine (referred to
as non-
vaccine type IPD), according to a study published in PLOS Medicine this week.
«From a pandemic - preparedness point of view, we should potentially start including some of these H3
strains as part of influenza
vaccines.»
This means that when an unexpected flu
strain appears, such
as the 2009 pandemic - causing H1N1 virus, there is no way to rapidly produce a
vaccine against it.
As a final confirmation of the compound's potential to stop a virus from spreading, they tested it against an actual virus: the nonpathogenic
vaccine strain of the Junin virus.
Current
vaccines, which require experts to pick the flu
strains that they believe are going to circulate in a given year, are typically 40 to 70 percent effective in the U.S., though in some years protection is
as low
as 20 percent.
These rare VDPVs arise when a virus used in the live
vaccine reverts from its weakened form and regains its virulence — a danger when vaccination rates are low,
as they are in both places, allowing the
vaccine strain to circulate and accumulate genetic mutations.
Our team proposes using the
strains containing all the identified evolutionary markers
as vaccine candidates for upcoming influenza seasons,» Kainov continues.
If the
vaccine is not a good match for the virus —
as is the case with the H5N1
strain now sweeping Asia — it can still replicate but most animals do not show signs of disease.
And even if they were more dangerous than common flu
strains, it would not make any difference because manufacturers kill the virus
as part of the
vaccine production process, notes the group.
Early tests of a gp120
vaccine looked promising, but optimism faded by the early 1990s
as researchers learned the
vaccine only worked against
strains of HIV that had adapted to conditions in the laboratory.
However, Acambis's Thomas Monath points out that the vehicle
strain used by Acambis has been used safely and effectively
as a
vaccine against yellow fever for decades, whereas the dengue chimera's safety is comparatively untested.
But he cautions that the cocktail of proteins that make up the
vaccine might need to be updated
as new disease - causing
strains of GBS emerge.
The best
strains we have for a H1N1 swine flu
vaccine grow only
as half
as fast
as ordinary
vaccine viruses, meaning poorer nations may not get it in time if there is a second wave
As anyone who's gotten sick despite a flu shot knows, a
vaccine that protects against one
strain of a pathogen doesn't necessarily protect against the others.
Hepatitis B virus, meanwhile, has already produced mutant
strains accepted
as being
vaccine - induced.
The virus itself will continue to mutate from year to year — a process referred to
as antigenic drift — and over time it becomes less well matched to the
vaccine strain, meaning that the antibodies you generate from getting the
vaccine may be less effective in neutralizing the circulating virus.
So, due to natural changes in the virus
as it evolves,
as well
as due to mutations that may be caused by growing the
vaccine strain, the circulating virus and the
vaccine become less well matched over time.
Finally, MAIT cells are activated in human volunteers receiving an attenuated
strain of Shigella dysenteriae - 1 tested
as a potential
vaccine.
For mouse
strain specificity, Balb / c mice were included for consistency between experiments; C57BL / 6 mice were given the same
vaccines and dosages
as Balb / c mice for comparison
as C57BL / 6 mice do not exhibit a bias for Th2 immunologic responses
as do Balb / c mice [37]--[39].
An experimental
vaccine poised to win World Health Organization approval
as the first to even partially protect children against malaria works better against one
strain of the disease - causing parasite than others.
There are many variations of H1N1, says Rafi Ahmed, director of the Emory
Vaccine Center and a Georgia Research Alliance Eminent Scholar, but this technology could be used to identify a very specific
strain, such
as the one weâ $ ™ re dealing with in the current pandemic.
What can you do when there's an epidemic of flu sweeping the country and the CDC has warned that the flu
vaccine may not be
as effective
as in other years for this year's
strain of the virus?
Introducing the Gardasil
vaccine Gardasil, the HPV
vaccine introduced in 2006, protects against the two
strains of the virus that are most likely to cause cancer,
as well
as the two
strains of the virus that are the culprits in most cases of genital warts.
In addition, the
vaccine may still offer some protection against the mutated
strain — meaning that if you do get it, your flu symptoms may not be
as severe.
There are many different
strains of the FIV virus and it is not entirely clear
as of yet how well the available
vaccine protects against all these different
strains, but studies suggests that it is able to provide a valuable degree of protection for cats at risk of exposure.
It's the
vaccine developers» best guess
as to whether or not the current infective organisms are the same
strain as the
vaccine, a process similar to what happens the human flu
vaccines.
Vaccines for parainfluenza and the two
strains of leptospirosis aren't classified
as essential for your pooch's health, although your vet may recommend them for your pup.
«
Vaccines that contain outdated
strains of influenza may provide only partial clinical protection, and may result in nasal shedding of the virus, oftentimes
as much
as an unvaccinated horse, thus putting other horses at risk.»
As with human flu shots, a
vaccine for one
strain doesn't help prevent another
strain.
Fluvac Innovator ®
vaccines are the most trusted equine influenza
vaccines and help provide your horse with broad protection against newly emerging and conventional equine influenza virus
strains as well
as equine herpesvirus (EHV 1 and EHV 4).4 - 10 Zoetis regularly tests Fluvac Innovator to ensure its
vaccine continues to be effective against emerging EIV isolates.
Regular canine
vaccines, such
as a 5 in 1, or a 7 in 1, offer some protection against kennel cough,
as many
strains of this infection, are caused by the parainfluenza virus.
There is some cross-protection for the H3N8
strain provided by the H3N2
vaccine, and vise versa, but not
as much
as we'd like.
Make an appointment at a Planned Parenthood health center to receive education about HPV,
as well
as the preventive
vaccine, Gardasil, which protects against two cancer - causing
strains of the virus.