The immunological benefits from the wild mice's gut bacteria may, in part, explain a persistent problem in disease research: Why disease experiments in lab mice, such
as vaccine studies, turn out very differently in humans or other animals.
Not exact matches
Harpal Kumar, Cancer Research UK's chief executive, said: «
As someone with an ethnic minority background myself and as a parent, this study highlights a very worrying reason why girls from some minority groups don't get the HPV vaccin
As someone with an ethnic minority background myself and
as a parent, this study highlights a very worrying reason why girls from some minority groups don't get the HPV vaccin
as a parent, this
study highlights a very worrying reason why girls from some minority groups don't get the HPV
vaccine.
The latest
study is the most thorough large - scale
study to date of the risk of febrile seizures following inoculation with the DTaP - IPV - Hib
vaccine, which protects against diphtheria, tetanus and pertussis (whooping cough),
as well
as polio and Haemophilus influenzae type b.
Protection against the disease pertussis, or whooping cough, doesn't appear to be
as strong with the currently administered
vaccine when compared with the older version administered up until the 1990s, according to a new
study in Pediatrics.
As part of their
study, the researchers collected tweets that mentioned measles - mumps - rubella
vaccine and classified their sentiment using artificial intelligence computer programs.
A multi-institutional
study,
as reported in the journal Infection Control and Hospital Epidemiology, shows that mandatory flu
vaccines for healthcare workers improve vaccination rates by
as much
as 30 percent and reduce absenteeism during critical periods by about six percent.
«It's a novel strategy, and it works beautifully,» said senior investigator Harvey M. Friedman, MD, a professor of Infectious Diseases at Penn. «I know of no other HSV2
vaccine candidate with published results that are
as promising
as this
study.»
Findings from this
study of flu
vaccines delivered by a small needle intradermally parallel earlier results that found adding a strain of influenza B could improve the effectiveness of a flu
vaccine nasal spray and a traditional intramuscular
vaccine that is injected
as a shot in the arm muscle.
Vaccines are successful in preventing pandemic flu and reducing the number of patients hospitalised
as a result of the illness, a
study led by academics at The University of Nottingham has found.
The organization supports
vaccine - related research, and Singer knew that her bosses would expect her to vote for more
studies of
vaccines as a possible cause of the condition.
In addition to a comprehensive
study of their use in
vaccines, this article summarizes the benefits and challenges associated with the use of these polymer systems
as adjuvants.
The nursing homes in the
study were randomly assigned to one of two groups
as a care standard for influenza prevention, with either the regular dose of the influenza
vaccine or the high dose
vaccine as the care standard for their residents age 65 and older.
Scientists have moved closer to developing a universal flu
vaccine after using the 2009 pandemic
as a natural experiment to
study why some people seem to resist severe illness.
The results from the
study could be used to help public health officials to plan a more effective response to future pandemics, such
as rolling out
vaccines at a much earlier time and targeting specific types of
vaccines at different age groups.
Last year the National Institutes of Health announced plans to put some 180 ex-Coulston chimps currently housed at the Alamogordo Primate Facility back in service, to rejoin the roughly 800 other chimps that serve
as subjects for
studies of human diseases, therapies and
vaccines in the U.S., which is the only country apart from Gabon to maintain chimps for this purpose.
«We are pleased to have demonstrated such a potent and durable immune response to the
vaccine,» said the
study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the
vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections
as well, especially in high - burden regions of sub-Saharan Africa.»
Ding's next goal is to raise $ 5 million so he can spend about five years
studying new
vaccines for human pathogens such
as dengue fever.
«Now that we know the mice can be vulnerable to Zika infection, we can use the animals to test
vaccines and therapeutics — and some of those
studies are already underway —
as well
as to understand the pathogenesis of the virus,» said senior author Michael Diamond, MD, PhD, a professor of medicine at Washington University.
«From what we have seen in this small preliminary
study in young children, this experimental
vaccine is working
as we hoped it would.»
For example, in our film we took Brian, who
studies risk, to a football game where he used the stadium
as a metaphor to show how extremely rare
vaccine - related injuries really are.
Vaccination with the pneumococcal conjugate
vaccine - 7 [PCV7 — a
vaccine that covers 7 strains (serotypes) of Streptococcus pneumoniae] is linked to overall decreases in the rate of serious infections caused by this bacterium, such
as pneumonia and meningitis, referred to
as invasive pneumococcal disease (IPD)-RSB-, but small increases in IPD caused by serotypes of Streptococcus pneumoniae not covered by the
vaccine (referred to
as non-
vaccine type IPD), according to a
study published in PLOS Medicine this week.
A new flu
vaccine sprayed into the nose may be just
as good
as a shot in the arm, according to a
study in this week's Journal of the American Medical Association.
For instance, people who insist that
vaccines cause autism may point to the known dangers of mercury
as evidence, even though mercury is no longer a component of most
vaccines, and
studies have found no link between
vaccines and autism.
As part of the
study, groups of 18 to 20 female mice were vaccinated with one of the
vaccines or a placebo, and some animals received a second dose of the same
vaccine or placebo a month later.
A group from the NIH's National Institute of Allergy and Infectious Diseases (NIAID) evaluated the live imaging system
as a potential alternative to traditional methods of assessing investigative influenza
vaccines and treatment in mice, which can be time consuming and require more
study animals for valid statistical comparison.
While the effect of
vaccines was not analyzed
as part of this
study, Rzhetsky notes that the geographic clustering of autism and ID rates is evidence that if
vaccines have a role, it's a very weak one
as vaccinations are given uniformly across the US.
Kang's primary research focuses on designing and developing effective
vaccines against viral diseases such
as influenza virus and RSV, but he partnered with a university and research institutes in South Korea that wanted international collaborative projects to
study if ginseng can be used to improve health and protect against disease because of the potential benefit in fighting these viruses.
Recent
studies have shown that locally made Chinese
vaccines are less effective than imported versions, which cost five to 10 times
as much.
In their new
study, researchers from the Johns Hopkins Bloomberg School of Public Health, Imperial College London and the University of Florida re-analyzed data from
vaccine trials conducted in 10 countries with more than 30,000 participants
as well
as recently published data on the long - term follow - up of these participants.
For the near term, groups known
as accelerated development and introduction plans (ADIPs) have
studied the possibility of more rapidly introducing new
vaccines for rotavirus, a common diarrheal disease, and pneumococcus, a bacterium that causes pneumonia.
Unpredictable demand creates a three - way catch - 22 problem,
as pointed out in a 2002
study commissioned by the GAVI Alliance, formerly the Global Alliance for
Vaccines and Immunization.
Studies in patients suggest these systems have potential
as therapies and
as vaccines
DNA
vaccines have been
studied in animal models of viral, bacterial, and parasitic disease,
as well
as animal models of tumors.
A recent
study on 749 men in Brazil showed that a 46-fold diluted
vaccine triggered the same antibody response
as a full dose.
«Hepatitis C mutations «outrun» immune systems, lab
study shows: Study identifies mutations outside of traditional vaccine targets as barrier to vaccine development.&r
study shows:
Study identifies mutations outside of traditional vaccine targets as barrier to vaccine development.&r
Study identifies mutations outside of traditional
vaccine targets
as barrier to
vaccine development.»
Also, he says, the
study shows that high - risk groups, such
as researchers and lab technicians working with West Nile, should consider getting a JE shot
as long
as there's no specific West Nile
vaccine.
But a new animal
study shows that the
vaccine performs much better when given intravenously instead of into the skin,
as it was in the clinical trial.
Thus,
as Americans have expanded their sexual repertoire,
as an October
study from The Journal of Sexual Medicine highlighted, prevalence of HPV can sweep quickly through a population — especially one that is unprotected by a
vaccine or consistent condom use.
An Australian
study recently reported that kids who were given the acellular
vaccine as infants were more than three times
as likely to get pertussis between 2009 and 2011 than were those who received the whole - cell version.
Since the outbreak exploded in August, researchers have vigorously debated how to set up Ebola drug and
vaccine studies, with some advocating randomized controlled
studies, in which one group of patients doesn't receive the drug,
as the quickest way to get results.
In a previous
study, investigators at the Cancer Institute showed that using a
vaccine treatment for bladder and breast cancer tumors in laboratory models resulted in a reversal of the traditional immune blockade,
as well
as the development of tumor specific immunity throughout the body.
One gene produces a protein known to help the parasite infect red blood cells and is already under
study as a target for a
vaccine.
«Taken together, these two
studies suggest that the new scalable
vaccine formulation is likely to prove
as effective
as the original formulation — which would make it the first protective TB
vaccine in humans since BCG, which was introduced almost a century ago,» said Professor Ajit Lalvani, Director of the Tuberculosis Research Centre, National Heart and Lung Institute, Imperial College London and a member of the DAR - 901 development team.
The bacterium that causes whooping cough, Bordetella pertussis, has changed in Australia — most likely in response to the
vaccine used to prevent the disease — with a possible reduced effectiveness of the
vaccine as a result, a new
study shows.
«Instead of administering a cancer
vaccine to destroy tumors, we hope to modify the immune system to allow the patient's own tumor to act
as a cancer
vaccine,» said Hyung Lae Kim, MD, co-medical director of the Urologic Oncology Program and lead author of the
study.
As a next step, Kurtis's group is conducting a
study of the
vaccine in nonhuman primates.
He said that prior research has shown that it is very hard to completely debunk misinformation, such
as the mistaken belief that the MMR
vaccine causes autism, but the
study results suggest that accurately communicating about the risks of Zika can help lessen the detrimental effects of the misbelief.
The fog around the largest AIDS
vaccine study ever conducted began to lift today,
as Thai and U.S. researchers for the first time publicly presented a detailed analysis of their data to over 1000 scientists gathered here at an annual meeting.
Thus, this
study has implications for analysis of human
vaccine studies,
as in addition to searching for defined lineages it is worthwhile to perform functional analysis of monoclonal antibodies that may have found new structural solutions to high affinity binding which can not be discerned from DNA sequence alone.
WHO today issued a «donor alert,» urgently requesting a 6 - month budget of $ 10.5 million to support the
vaccine study (which may require 5000 doses),
as well
as surveillance, treatment, and conventional prevention and control efforts.