Sentences with phrase «as young mice»

And to do so, Ottersbach and her team are trying to understand how the disease might begin, even before birth, by looking at cells in the lab as well as young mice with the disease.

Greater running distance in the 2 - to 3 - month - old mice may partially explain these data, but the solo - housed wild - type mice used to test solo - versus group - housing (Fig. 5) ran similar distances as the young mice, yet did not show any increase in brain progranulin levels.

These mice were able to control the infection as efficiently as young mice.

Overexpressing a single gene called Arc rejuvenates the visual cortex of middle - age mice, making them as plastic as younger mice.

Not exact matches

There are the usual suspects, like pricey pills and supplements, as well as the peculiar, such as infusions of blood from young mice or standing - room chambers pumped with sub-zero temperatures.

In September the red worm, and any other baits you can find, such as cherries, tender young mice without hair, and the honeycomb.

The reason for this is the emergence of his young team mate Francis Coquelin, who has been earning rave reviews for his disciplined and effective performance away to Man City, especially as he managed to keep the excellent Spanish creator David Silva as quiet as a mouse.

It's probably safe to say no D.J. played Modest Mouse at the uptown event, but white hair was still a hot accessory later in the night, as the older crowd gravitated towards the velvet couches (under the taxidermic animals) while younger bunches of volunteers, filmmakers, and tech consultants crowded the bars and would - be dance floor.

In 2014, highly publicized work in the laboratories of Villeda and Tony Wyss - Coray, PhD, professor of neurology at Stanford, showed that connecting the circulatory system of a young mouse to that of an old mouse could reverse the declines in learning ability that typically emerge as mice age.

Instead of impairing learning and memory, as it does in young people, the drug appears to reverse age - related declines in the cognitive performance of elderly mice.

As expected, young mice treated with THC performed slightly worse on behavioral tests of memory and learning.

Specifically, the researchers found that a peptide, called STAT6 - IP, when delivered to the lungs of neonatal mice at the time of first RSV exposure reduces the development of allergic - type lung inflammation and airway hyperresponsiveness («twitchy» airways) in mice when they are «re-challenged» with RSV as young adults.

To make their discovery, scientists infected mice with RSV, first as infants and then again as young adults.

After receiving an injection of neural stem cells from young mice, however, they performed as well as healthy mice did.

Researchers showed that limiting the supply or the function of the neuromodulator adenosine in a brain structure called the auditory thalamus preserved the ability of adult mice to learn from passive exposure to sound much as young children learn from the soundscape of their world.

After 4 weeks of connection to young mice, the five old mice's heart tissue had thinned and softened, looking just as spry and supple as the 2 - month - olds».

Furthermore, examination of aged mice showed dramatically reduced levels of Cbf - beta in bone marrow cells, as compared to younger mice.

When she and Duarte raised the burying beetle larvae with germ - free mice, which lack any gut bacteria, the young did not grow as large as those buried with regular mice.

Our study suggests otherwise, though, as we found that a certain type of B cell is quite abundant in the ventricles, meninges, and choroid plexus in the brains of young mice.

For example, he learned that young pine snakes begin feeding on adult mammals — small ones, such as mice — within the first two months of life and they shed their skin multiple times within their first season.

This artificial joining of two separate animals, known as parabiosis, was a staple of physiology experiments for over a century before Irina Conboy got the idea to pair an old mouse with a young one.

Although we did observe positive effects on some aging traits, such as memory impairments and reduced red blood cell counts, our studies showed that similar drug effects are also seen in young mice, indicating that rapamycin did not influence these measures by slowing aging, but rather via other, aging - independent, mechanisms.»

To get around these safety concerns and to potentially maximize therapeutic effects on tumors, Alvey and colleagues took fresh, young macrophages from human donors as well as mouse donors and directly blocked their SIRPA.

YOUNG blood has once again shown its promise as an elixir of youth: blood from young mice helps bones of older animals YOUNG blood has once again shown its promise as an elixir of youth: blood from young mice helps bones of older animals young mice helps bones of older animals heal.

The young mice showed signs of brain deterioration as well, including inflammation and decreased birthrates of new nerve cells.

As in the first study, a group of young mice carrying the human gene APOE4 showed cognitive impairment on the behavioral level — in other words, they showed signs of damage on the level of spatial memory.

But now that we know what kinds of changes occur as these cells age, we can ask which of these changes reverse themselves when an old cell goes back to becoming a young cell» — as appeared to be the case when tissues of older mice were exposed to blood from younger mice.

In one group of mice, he and his colleagues dosed their mothers with a synthetic compound that simulates a mild viral infection during late pregnancy; when their offspring hit early puberty at about 6 weeks of age, the young mice were exposed to unpredictable stress, such as being restrained, deprived of water, or given electric foot shocks.

Instead, they found, in quiescent satellite cells taken from the younger mice, copious instances in which histones in the vicinity of genes ordinarily reserved for other tissues were marked with both «stop» and «go» signals, just as genes associated with development to mature - muscle status were.

Their younger cousins recovered fine, as did older mice with telomerase intact, but more than half of the aged, telomere - depleted mice died from the treatment.

To try to exploit this phenomenon as a potential treatment, Datta injected large amounts of the peptides into young female mice of a strain prone to succumb to SLE.

As a consequence of the study many hundreds of young mice that would otherwise all have died were saved.

The team found they could replicate the healing abilities of the engineered mice by giving nongenetically altered ones drugs that help activate certain metabolic processes — the same pathway Lin28a stimulates — revving up and energizing cells as if they were much younger.

The researchers measured NF - κB activation in mouse brains as they aged and noted that, while the protein was barely active in the hypothalamuses of young mice, it became increasingly active as the mice got older.

Interestingly, younger mice did not benefit from NMN supplementation (likely due to the fact that the body naturally produces higher levels of NAD at younger ages), but as the mice aged, the supplementation significantly reduced signs of aging.

Young mice normally have an abundance of RbAp48 protein in their brains, and older mice have about half as much.

Scientists were able to identify the influence caused by factors unique to the blood of young mice, which could ultimately be used as treatments for age - related neurodegenerative disorders.

Analysis of exploration times during the test revealed significant object / age interaction (P = 0.0293, 3 - way ANOVA with age and treatment as between - subjects factors and object as within - subjects factors), indicative of preferential exploration of the object in the novel location by the younger animals and a lack of such preferential exploration in 20 - month - old mice.

These analyses revealed some of the same effects of rapamycin in young mice as in aging mice (decreased CD25 + CD4 + T cells; Figure 9C), whereas other effects were not present (no decrease in CD44hi T cell frequency; Figure 9E).

To test our hypothesis, we generated heterochronic parabiotic pairs between 15 - month - old (Het - O) and 2 - month - old (Het - Y) male mice, as well as control groups of age - matched pairs, namely isochronic young (Iso - Y) and isochronic old (Iso - O) pairs (fig.

This is a link to another recent Cell Metabolism study publication that looked at actual people as opposed to mice - Low Protein Intake Is Associated with a Major Reduction in IGF 1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population Cell Metabolism, Volume 19, Issue 3, 407 - 417, 4 March 2014

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While supplementing experimental mice with this microbial species, the investigators noted that the mice began to appear younger in as little as one week.

In the initial report, mice harboring a mutation in the core circadian gene Clock (termed Clock mutant mice) were fed a high - fat (HF) diet and observed to develop obesity at a young age, as well as a variety of metabolic and endocrine abnormalities consistent with the metabolic syndrome (2).

It's cute and simple and aimed at a young audience Still I found it incredibly funny when the animals came into play, a crying squirrel, some amorous glow bugs, and the mouse known as cheese were all charming and hilarious.

Edison Chen and Shawn Yue portray the younger Ming and Yan, just as they had done briefly in the first film, and while they are fine in their own way, this film really belongs to Hong Kong's veteran character actors Anthony Wong (The Medallion, Cat and Mouse), Eric Tsang, and Francis Ng.

Just like in nearly every other Pixar and Mouse House animated movie this Century, someone dies early on in «The Good Dinosaur» and Arlo must prove his worth as he battles enemies and the elements trying to make it back home to his family with the help of a new friend, a young cave boy.

Young Again CarnivoreRAW meat supplements are designed to make a raw meat diet as complete and nutritious as a mouse; one of Nature's most complete foods.

Label anything with Disney or Mickey Mouse and it is bound to sell well with both the younger gamer audiences and those like myself who love the Disney universe as a whole.

He initially experimented with Cubism and Abstract Expressionism, but found his signature style after his young son challenged him to paint as well as the artists in his Mickey Mouse comic book.